<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33662

Description Mediator complex subunit 14
SequenceMAPVQIGSDGQLVPAGGPTSALQPPPPGAPSGTPATHGVRLSVLIEFLLQRTYHEITLLAELLPRKTDMERKIEIVQFASRTRQLFVRLLALVKWASNAGKVEKCAMISSFLDQQAFLFVDTADRLASLARDALVHARLPSFAIPFAIDVLTTGSYPRLPTCIRDKIIPPDPITKAEKQATLSQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDIPWRLLKLEILVEDKETGDGRALVHSMQVSFIHELVQSRLFADEKPLQDMYNCLHSFCLSLQLEVLHSQTLMLIRERWGDLVQVERYIPAKCLTLAVWNQQVLGRKTGTASVHKVHIKIDETDGSKPLQISHEPLLPACDSKLMERAMKIDHLSVEKLLIDSVHARSHQKLQELKAILKNYNPSDNSFIETALPTLVIPILEPCGRSECLHIFVDLHSGTFQPMLYGTDQSTLDEMEKSINDDMKRIIPWLQQLKFWLGEQRCRQSVKHLPTVCSKTLHLSNAASHPAGSLSKHRLFIRLTRLPQYYIVAEMFDVPGCPTELEYKYYFLSVTMLEGDEGPPSAQLLQQFKPNLEELVLDATPGRGAKSGTKRKLSGDQGAIEPKKPKRAGEMCAFNKVLAHLVAMCDTNMPFIGLRCELSTMEIPHQGVQVEGDGCSHAIRILKIPPSKGVSEETRRVLERSLLDCTFRLQGRNNRTWVAELVFANCPLTSTSSKEQASTRHVYLTYENPLSEPVGGRKVVEMFLNDWCSIAQLYECVLDFARSLGDMPSYLSLFSEIRLYNYRKLVLGYGSTKGSSITIQWNSVTQKFHISLGTVGPNSGCSNCHNIILHQLQEMFNKTPSVVQLLQVLFDTQGPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSPTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNTKIVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPVGVDVMDALMSQLQPPPGQPQPFGKQAGGTGVYPITSPPTSYHTGVTPSPSMMPTQSPGTIHAASSPSGALRAPSPASFGPTPSPSSLGISMGQTSNFASPHGTLDPSSPYALMSPGQRSSNWPGSPQVSGPSPAARMPGMSPANPSLHSPIPDASHSPRAGTSSQAMPTNMPPPRKLPQRSWAASIPTILTHSALHVLLLPSPTPCLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQEPNLQIVNSNEPGVIMFKTDVLKCRVALNPKTYQTLQLKVTPDNTGPWSQEELQVLEKFFETRVAGPPFKYNTLNAFTKLLGAPTHILRDCVRIMKLELFPDQATQLKWNVQFCLTIPPSAPPIAPPGTIAVVLKSKMLFFLQLTQRLPVPQEPISIIVPIVYDMATGLTQQADIPRQPSSSGAAALMVSSILKRFNEMHPPRQSECTIFASVHELMANLTLPPGGRP
Length1445
PositionTail
OrganismLepisosteus oculatus (Spotted gar)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Holostei> Semionotiformes> Lepisosteidae> Lepisosteus.
Aromaticity0.07
Grand average of hydropathy-0.162
Instability index53.42
Isoelectric point8.72
Molecular weight159574.72
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
blood vessel morphogenesis	GO:0048514	IEA:Ensembl
embryonic viscerocranium morphogenesis	GO:0048703	IEA:Ensembl
neural crest cell differentiation	GO:0014033	IEA:Ensembl
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central
stem cell population maintenance	GO:0019827	IEA:Ensembl
ventricular system development	GO:0021591	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33662
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     121.34|      30|      32|    1022|    1053|       1
---------------------------------------------------------------------------
  972- 1007 (42.16/11.34)	DNPPSPVGVdvMDAlmsqlqPPP...G.QP....QP..FGKQAGGT
 1039- 1071 (43.88/18.12)	HAASSPSGA..LRA......PSPasfGpTP....SPSSLGI.SMGQ
 1073- 1102 (35.31/ 9.96)	SNFASPHGT..LDP......SSP.......yalmSPGQRSSNWPG.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     137.37|      41|     281|     829|     952|       2
---------------------------------------------------------------------------
  869-  910 (69.22/63.21)	LNAINKLPTVPMLGLTQRTNTaYQCFSILPQSPTHI.RLAFRN
 1270- 1311 (68.15/18.90)	LQVLEKFFETRVAGPPFKYNT.LNAFTKLLGAPTHIlRDCVRI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      97.93|      22|     103|     572|     593|       3
---------------------------------------------------------------------------
  572-  593 (37.12/21.56)	PPSAQLLQQFKPNLEELVLDAT
  618-  635 (24.36/11.56)	PKRAGEMCAFNKVLAHLV....
  678-  699 (36.45/21.03)	PPSKGVSEETRRVLERSLLDCT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.60|      13|      34|     290|     302|       4
---------------------------------------------------------------------------
  290-  302 (23.20/16.15)	CLSLQL...EVLHSQT
  324-  339 (17.39/10.12)	CLTLAVwnqQVLGRKT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     107.46|      26|     102|    1011|    1037|       5
---------------------------------------------------------------------------
 1011- 1035 (46.54/21.55)	........PI....TSP.PTSYHTGVTPSPSM.MPTQSP
 1121- 1150 (28.21/10.10)	A.........npslHSPiPDASHSPRAGTSSQaMPTNMP
 1157- 1187 (32.71/14.22)	QrswaasiPT....ILT.HSALHVLLLPSPT...PCLVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     209.83|      54|     508|     812|     868|       6
---------------------------------------------------------------------------
   28-   63 (35.37/14.03)	.................GAPSGTPATHGVRLSVLIEfLLQRTYHEITLLAELL.....
  812-  868 (91.21/56.97)	IQWNSvtqKFHISLGTVGPNSGCSNCHNIILHQLQE.MFNKTPSVVQLLQVLFDTQGP
 1324- 1371 (83.25/45.37)	LKWNV...QFCLTIPPSAPPIAPPGTIAVVLKSKML.FF......LQLTQRLPVPQEP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     104.59|      30|     244|     218|     247|       9
---------------------------------------------------------------------------
  177-  215 (28.80/14.83)	.EKQATLSQL....NQilrhrlvTTD..LPPQLANLTVAngrVKFR
  218-  247 (52.25/33.64)	GEFEATLTVM....GD.......DPD..IPWRLLKLEIL...VEDK
  459-  486 (23.55/10.63)	GTDQSTLDEMeksiND.......DMKriIPW.LQQL..........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.03|      17|     442|      80|     105|      10
---------------------------------------------------------------------------
   80-   96 (29.21/38.15)	SRTRQLFV....RLLALVKWA
  113-  133 (22.82/ 6.95)	DQQAFLFVdtadRLASLARDA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33662 with Med14 domain of Kingdom Metazoa
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