<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33659

Description Mediator complex subunit 26
SequenceMTAASATPQQMRDRLLQAIDSQSNIRNMVAVLEVISSLEKYPITKEALEETRLGKLINDVRKKTKDEDLAKRAKKLLRNWQKLIEPGQNETLPRGGPGTPGSANGGSHPCRPEIAPPAVSPVGKPVQELKSRNDIHNSYSPKLEKSSNRKRKGEQRDGHLSAKISKAANDRLQNSTPPPTNGIGGSPEPFPSPLDPSGLPGPDRSRTEHLENDKHNKIPVNAVRPHTSSPGLAKPPSTSSLLKTAVMQQHAKMDEVSGGGGGGGSGQPQPRSPRCASFSPRSIKEETMAKRPTTYAPKGTLSSPSQSSRFLDVAARVQSPLPLPQPLTPPVQVSHTDGPQPPGPESSRHWHGPADADLRLQHSTGTLELPPHSSPHGSRTALHHSECTVPHGLGLPSEAAKLDSDGAASSSESKRKKKYRPRDYTVNLDGQPAMEESTKPVRLKERKLTFDPVTGQIKPLTHKESYQGEEPVGLPLPEAHRTDVLKQKPGAPLPSPFQQTNWKELSRNEIIQSYLSRQSSLLTSSGAQTPGAHFFMTEYLKQEEHDIKESRKTHVLVPDSSETDLPGVSRDVTTEDLHRIHQERWPGVNGCFDTKDNWYDWTQCISLDPHGDESKLHILPYVCLD
Length625
PositionUnknown
OrganismLepisosteus oculatus (Spotted gar)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Holostei> Semionotiformes> Lepisosteidae> Lepisosteus.
Aromaticity0.04
Grand average of hydropathy-0.897
Instability index65.81
Isoelectric point9.01
Molecular weight68415.86
Publications









Function






Annotated function


GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
positive regulation of gene expression	GO:0010628	IBA:GO_Central
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33659
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     454.54|      76|      76|      94|     169|       1
---------------------------------------------------------------------------
   94-  169 (131.55/55.40)	RGGPGT....P.GSANGGSHPC..R.PEIAPPAVSPVGKPVQELKSR.....NDIHNSYSPK.LEKSSNRKR...KGEQR......DG.HLSAKISKAAN
  171-  247 (88.51/34.78)	RLQNST....P.PPTNGIGGS.....PEPFPSPLDPSGLPGPD.RSRtehleNDKHN....K.IPVNAVRPHtssPGLAK......PP.STSSLLKTAVM
  257-  291 (39.56/11.33)	SGGGG.......G...GGS..................GQP....QPR.....SPRCASFSPRsIKEETMAKR............................
  292-  354 (71.86/26.80)	...PTT..yaPkGTLSSPSQSS..RfLDVAARVQSPLPLP.QPL...............TPP.VQVS...HT...DGPQP......PG.PESSRHWHGPA
  361-  430 (57.16/19.76)	QHSTGTlelpP.HSSPHGSRTAlhH.SECTVP..HGLGLPSEAAKLD.....SDGAASSS......ESKRKK...KYRPRdytvnlDG............
  473-  534 (65.89/23.94)	.GLP.L....P.EAHRTDVLKQ..K.P..GAPLPSPFQQTNWKELSR.....NEIIQSYLSR...QSSLLTS...SGAQT......PGaHF.........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.87|      15|      17|     439|     453|       2
---------------------------------------------------------------------------
  439-  453 (26.25/17.38)	KPVRLKERKLTFDPV
  458-  472 (27.62/18.69)	KPLTHKESYQGEEPV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33659 with Med26 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) KLLRNWQKLIEPGQNETLPRGGPGTPGSANGGSHPCRPEIAPPAVSPVGKPVQELKSRNDIHNSYSPKLEKSSNRKRKGEQRDGHLSAKISKAANDRLQNSTPPPTNGIGGSPEPFPSPLDPSGLPGPDRSRTEHLENDKHNKIPVNAVRPHTSSPGLAKPPSTSSLLKTAVMQQHAKMDEVSGGGGGGGSGQPQPRSPRCASFSPRSIKEETMAKRPTTYAPKGTLSSPSQSSRFLDVAARVQSPLPLPQPLTPPVQVSHTDGPQPPGPESSRHWHGPADADLRLQHSTGTLELPPHSSPHGSRTALHHSECTVPHGLGLPSEAAKLDSDGAASSSESKRKKKYRPRDYTVNLDGQPAMEESTKPVRLKERKLTFDPVTGQIKPLTHKESYQGEEPVGLPLPEAHRTDVLKQKPGAPLPSPFQQTNW
75
502










Molecular Recognition Features






MoRF SequenceStartStop




1) KRKKKYR
2) LLKTAVMQQHAK
3) RDYTVNLD
414
241
422
420
252
429