<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33651

Description Cyclin-dependent kinase 8
SequenceMDYDFKVKLTGERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYALKQIEGTGSPCLRLLRELKHPNVISLQKVFLSHADRKVWLNLNCVCVCLCVSLNPCASTGMVTSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKLLTMDPIRRITSEQAMQDPYFLEEPLPTSDVFAGCQIPYPKREFLTEEEPEDKADKKNQQQQGNNHTNGAGHTGNPDNSHAQGPPLKKVRVVPPTTTSSGLIMASDYQRSNPHAAYQNPGPSTSLPQSSMGYSTTSQQPPQYSHQTHRY
Length399
PositionKinase
OrganismAstyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Ostariophysi> Characiformes> Characoidei> Characidae> Astyanax.
Aromaticity0.08
Grand average of hydropathy-0.663
Instability index36.52
Isoelectric point8.76
Molecular weight45387.28
Publications
PubMed=25329095

Function

Annotated function 
GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-UniRule
protein serine/threonine kinase activity	GO:0004674	IEA:UniProtKB-KW

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33651
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     114.94|      33|      35|     216|     249|       1
---------------------------------------------------------------------------
  216-  249 (54.91/37.26)	MKDFRRNTYTNCSLIKYMEKHKVkPDSKAFHLLQ
  254-  286 (60.03/36.65)	MDPIRRITSEQAMQDPYFLEEPL.PTSDVFAGCQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.44|      15|      36|     135|     149|       3
---------------------------------------------------------------------------
  135-  149 (26.77/18.81)	DLKPANILVMGEGPE
  173-  187 (28.67/20.64)	DLDPVVVTFWYRAPE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33651 with CDK8 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) YPKREFLTEEEPEDKADKKNQQQQGNNHTNGAGHTGNPDNSHAQGPPLKKVRVVPPTTTSSGLIMASDYQRSNPHAAYQNPGPSTSLPQSSMGYSTTSQQPPQYSHQTHRY
289
399










Molecular Recognition Features






MoRF SequenceStartStop




NANANA