<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33649

Description Cyclin-dependent kinase 19
SequenceMDYDFKTKLAAERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDEKEYALKQIEGTGISMSACREIALLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANKKPMQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPTKRITSEQSLQDPYFLEEPLPTSDVFAGCQIPYPKREFLNEDEPEEKTEKNQTQQHQQTAAQTQAQTQTQTQQAQSQQSSAQTNGTSGATGGNTGPSIQHGQDQGPPNKKPRIGPSGATSGTNVLQSDYQHSGSRLGYQSNVQGSTQSQSTMGYSSSSQQSSQYSHQSHRY
Length447
PositionKinase
OrganismAstyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Ostariophysi> Characiformes> Characoidei> Characidae> Astyanax.
Aromaticity0.09
Grand average of hydropathy-0.835
Instability index50.37
Isoelectric point8.54
Molecular weight51024.74
Publications
PubMed=25329095

Function

Annotated function 
GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-UniRule
protein serine/threonine kinase activity	GO:0004674	IEA:UniProtKB-KW

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33649
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     116.89|      28|      28|     349|     376|       1
---------------------------------------------------------------------------
  333-  347 (23.22/11.02)	QQTAAQTQAQTQT...............QT
  349-  376 (51.13/33.34)	QAQSQQSSAQTNGTSGATGG.NTGPS.IQH
  378-  407 (42.54/26.47)	QDQGPPNKKPRIGPSGATSGtNVLQSdYQH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.37|      14|      40|     111|     149|       2
---------------------------------------------------------------------------
   95-  108 (26.47/36.69)	LLFDYAE.....HDLWHII
  131-  149 (19.90/11.54)	LLYQILDgihylHANWVLH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.46|      30|      36|     235|     265|       3
---------------------------------------------------------------------------
  235-  265 (48.44/35.26)	LQKDF.....RRTTYANSSLIKYMEKHKVkPDSKVF
  268-  302 (46.02/28.80)	LQKLLtmdptKRITSEQSLQDPYFLEEPL.PTSDVF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     139.97|      43|     151|      12|      55|       4
---------------------------------------------------------------------------
   12-   55 (69.94/52.25)	ERERVE.DLFEYeGCKVGR.GTYGHVYKAKRKDGKDEKEYALKQIE
  165-  209 (70.03/47.61)	ERGRVKiDIWAI.GCIFAElLTSEPIFHCRQEDIKTSNPFHHDQLD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.04|      12|      14|     412|     425|       5
---------------------------------------------------------------------------
  412-  423 (22.48/13.93)	LGYQSNVQGSTQ
  428-  439 (22.56/ 7.56)	MGYSSSSQQSSQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33649 with CDK8 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IPYPKREFLNEDEPEEKTEKNQTQQHQQTAAQTQAQTQTQTQQAQSQQSSAQTNGTSGATGGNTGPSIQHGQDQGPPNKKPRIGPSGATSGTNVLQSDYQHSGSRLGYQSNVQGSTQSQSTMGYSSSSQQSSQYSHQSHRY
307
447










Molecular Recognition Features






MoRF SequenceStartStop




1) LGYQSNV
2) NKKPRIGP
3) QYSHQSHRY
412
384
439
418
391
447