<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33648
Description |
Mediator of RNA polymerase II transcription subunit 8 |
Sequence | MQQREEKQLEASVESLISRVAHLKNSLQSFIYKLENEYDRLTWPSVLDNFALLSGQLNTVNKLLRNEKTPSYRNQVIIPLLLSPDRDEDLAKLTEQRVPVFSHEIVPDHLRTKPDPEVEEQEKQLSVEAARIGPEVAQKQIQTMNKLCSSLLEKLNNPRDDREAETAAIRQNKPSFNPTDTTALVAAVGFGKGLSKCRPPGPVNTGHPGQPMMTGGPTLQQVTIAGTSGHQAGMGASVAQQQPGQPGKMPSSIKTNIKSASGSMHPYNR |
Length | 269 |
Position | Head |
Organism | Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi>
Actinopterygii> Neopterygii> Teleostei> Ostariophysi> Characiformes>
Characoidei> Characidae> Astyanax.
|
Aromaticity | 0.04 |
Grand average of hydropathy | -0.642 |
Instability index | 40.83 |
Isoelectric point | 8.47 |
Molecular weight | 29604.20 |
Publications | PubMed=25329095
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364144
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP33648
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 83.65| 28| 29| 64| 92| 1
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64- 92 (43.76/30.82) LRNEKTPSYRNQvIIP..LLLSPDRD.EDLAK
93- 123 (39.89/23.54) LTEQRVPVFSHE.IVPdhLRTKPDPEvEEQEK
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 79.77| 24| 32| 203| 229| 2
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203- 229 (40.45/26.51) VNTGHPGQPmmtGG.PTLQQVTIAGTSG
238- 262 (39.31/18.67) VAQQQPGQP...GKmPSSIKTNIKSASG
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