<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33645

Description Mediator complex subunit 12
SequenceMAAFGMLSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVNFNPSKISSNFSSIIAEKLRCNTFPDTGKRKPQVNQKDNFWLVTARSQSSINIWFTDLAGTKPLTQLAKKVPIFSKKEEVFGYLAKYSVPVMRSAWMIKMTCAYHAAITETKVKKRHVIDPCIEWTQIITKYLWEQLQKVAEFYRQSPSQGCGSPLPATPAEVETAMKQWEYNEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLQYSGEFVQSAYLSRRLAYFCTRRLNLLLSDGSLGLSTGGHPPHSISGQPGNALPPTPTSQPAGGNQPQTPFTDFYICPQHRPVVFGLSCMLQSIVLCCPSALVWHYSLTDSRNKTGSPLDLLPIAPSNLPMPGGNSTFNQQVRAKVREIEEQIKERGQAVEFRWSFDKCQETTAGFTIGRVLHTLEVLDNHSFEKSDFSNSLDSLYNRIFGSGQSKDGHEMSPDDDAVVTLLCEWAVCCKRSGRHRAMVVAKLLEKRQTEIEAERCGESEVVDEKGSVSSGSLSAATVPVFQDVLLQFLDTQAPVLTEPGNESERVEFSNLVLLFCELIRHDVFSHNIYMCTLISRGDLASDSHLPRPRSPSDEPSDESERKEQDTGSSVKMEDTGLSEPMEIEHNSSANFDEMFSPPMHGEAKGSPSPEKAAPEQDGKSTAKEKCMDPAFPQVYEQPRHIQYATHFPIPQEESASHECNQRQVVLYGVGKQRDEARHAIKKITKDILKVLNRKSTAETGGEEGQKRKRSKPEAFPTAEDIFSKFQHLSHFDQHQVTSQVSRNVLEQITSFALGMSYHLPLVQHIQFIFDLMEYSLNISGLIDFAIQLLNELSLVEAELLLKSSSLAGSYTTSLCLCIVAVLRRYHSCLILNPDQTAQVFDGLRIVVKSGVNPADCSSAERCILAYLYDLYTSCSHLKSKFGEIFSEFCSKVKNSIYWNIDPSDSNMLWDQVFMIDAIANPSAHNLNHSMVGKILNDSPANRYSFVCNVLMDVCVDHRDPERVNDIGILCAELTAYCRSLSAEWLGVLKALCCSSNNGNCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLVRCVAIPSLLNAACSEQDSEPGARLTCRILLHLFRTPQRNPCPQDGKSDKSTVGIRSSCDRHLLAASQNSIVVGAVFAVLKAVFMLGDAELKGSGFSHPAGLDDIGEDDMGSKKSGGRNVSIETASLDVYAKYVLKSICQQEWVGERCLKSLSEDSSALQDPVLVNIQAQRLLQLICYPHRQLDSEEGDNPQRQRIKRILQNMDQWTMRQSSLELQLMIKQSSNNELYSLLENIAKATIEVFQKSAEMNSSNPSWNGSAASSSSVSNSNNASKLKPVLRWVTPIRAYPRTETDEKCIQNLSREIVTNWREDQYQDDCKAKQMMHEALKLRLNLVGGMFDTVQRSTQQTNEWAVLLLDIISSGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLVKKLRKELGDRQSESLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFEKEGLQVSTKQKISPWDVFEGLKHSAPLSWGWFGTVRVDRKVTRFEEQQRLLLYHTHVKPRPRSYYLEPLPLPPEEEEPPTPVPQEPEKKMVEAVKSEKNVTSVPPDANKKKKKKKTPSTSKQEDYPARNPGVMPYGPGTNNELMNMGQSGHTYRMGYNQTSIIYTQNQPLPPGGPGLEPPYRPRMPVNKMPTRPNYPGNYHPGGMGIMGMDNKQYTMGFKPQTAMSQGQMLRQQIQSMLGQQMRPMAPNQQYSSMQPAQNISQQGYTSYGSHMVMQPHPSQTGAIVPSQYGNQAFQGAHPGTNPGVVDPLRQMPRPSGYVHQQASSAYGMQNTQRFAHQPMQQASMMHGLPQGHMAAQGVHPGMRPNQILDQQQQAAQQQQQQFLRQQALRVCAHQHCYSLFSWDFVLIISSASYSTGCYPQDTVGGLFSFQQCN
Length2026
PositionKinase
OrganismAstyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Ostariophysi> Characiformes> Characoidei> Characidae> Astyanax.
Aromaticity0.07
Grand average of hydropathy-0.460
Instability index52.33
Isoelectric point6.51
Molecular weight226732.10
Publications
PubMed=25329095

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33645
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     390.11|      79|     119|    1777|    1857|       1
---------------------------------------------------------------------------
 1717- 1777 (73.10/34.10)	...PAR.....NPGVMPY.....GPG.TnneLMNMG.QSGHTYRMGYN.QTSIiyTQNQP.LPPGGPG.LEPP.YRPRMP....................
 1779- 1857 (152.05/77.81)	NKMPTR.....PNYPGNY.....HPG.G...MGIMG.MDNKQYTMGFKPQTAM..SQGQM.LRQQIQSMLGQQ.MRPMAPNQQYS..SMQPAQNISQQGY
 1867- 1939 (79.17/40.30)	QPHPSQtgaivPSQYGNQafqgaHPGtN...PGVVDpLRQMPRPSGYVHQQAS..SAYGM...QNTQRFAHQ....PM...QQAS..MMH..........
 1941- 2006 (85.80/41.51)	.............LP.........QG.H...MAAQG.VHP.....GMRPNQIL..DQQQQaAQQQQQQFLRQQaLRVCAHQHCYSlfSWDFVLIISSASY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     146.67|      46|     702|      15|     107|       2
---------------------------------------------------------------------------
   16-   66 (73.57/105.26)	RPRlGPPDvYPQDPKQKEDELTALNVKQ...GFNNQPAVsgdEHGSAKNVN..FNP
  637-  687 (73.11/26.66)	RPR.SPSD.EPSDESERKEQDTGSSVKMedtGLSEPMEI...EHNSSANFDemFSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.45|      26|      52|     828|     855|       3
---------------------------------------------------------------------------
  828-  853 (42.80/35.43)	SQVSRNVLE..QITSFALGMSYHLPLVQ
  859-  886 (36.65/21.28)	FDLMEYSLNisGLIDFAIQLLNELSLVE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.51|      13|      31|    1147|    1159|       4
---------------------------------------------------------------------------
 1147- 1159 (24.42/16.45)	SEPGARLTC.RILL
 1179- 1192 (20.09/12.06)	STVGIRSSCdRHLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     133.10|      37|     702|     699|     764|       5
---------------------------------------------------------------------------
  705-  741 (70.37/77.35)	EQDGKSTAKEKCMDP.AFPQVYEQPRHIQYATHFPIPQ
  788-  825 (62.74/21.39)	ETGGEEGQKRKRSKPeAFPTAEDIFSKFQHLSHFDQHQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.56|      24|      57|    1016|    1043|       6
---------------------------------------------------------------------------
 1016- 1039 (44.78/26.69)	LNHSMVG..KIL....NDSPANRYSFVCNV
 1070- 1099 (32.77/14.94)	LSAEWLGvlKALccssNNGNCGFNDLLCNV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.62|      13|     133|     210|     222|       7
---------------------------------------------------------------------------
  210-  222 (28.16/13.07)	P.SQGCGSPLPATP
  337-  350 (23.46/ 9.64)	PtSQPAGGNQPQTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     421.72|     112|     125|    1358|    1481|       8
---------------------------------------------------------------------------
 1250- 1356 (123.66/73.04)	....IETASLDVYAKYVLKSIC.....QQEWVGE.RCLKSL...SEDSSALQdPVLVNIQAQRllqliCYPHrqldsEEGDNPQRQRI............KR.ILQNM..DQWtmrQSSLELQLMIK..................................QSSNNELY
 1358- 1481 (182.18/132.61)	LLENIAKATIEVFQKSAEMNSS.....NPSWNGS.AASSSSVSNSNNASKLK.PVLRWVTPIR.....AYPR.....TETDEKCIQNL............SREIVTNWreDQY...QDDCKAKQMMHealklrlnlvGGMFDT............VQRST.QQTNEWAV
 1483- 1608 (115.87/67.94)	LLDIISSGTVDM.QSNNELFTTvldmlSVLINGTlAADMSSISQGSMEENKR.AYMNLVKKL.........R.....KELGDRQSESLekvrqllplpkqTRDVIT.............CEPQ..............GSLIDTkgnkiagfekegLQVSTkQKISPWDV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.65|      10|      35|     196|     205|      11
---------------------------------------------------------------------------
  196-  205 (19.21/ 9.48)	WEQLQKVAEF
  232-  241 (20.44/10.49)	WEYNEKLAMF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33645 with Med12 domain of Kingdom Metazoa
Unable to open file!