<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33644

Description Mediator complex subunit 23
SequenceMFMDTPEDERTKLISCLGAFRQYWSSLPEESHEQCVQWIVRFIHSQHSPKRISFLYDCLAMAVETSLLPPRMVCQALINSDSLEWERTQLWALTFKLIRKIIGGVDYKGVRDLLKAVLDKVQTIPNLVSSAVVHQLLPVREVVEYILDRNACLLPAYFAVNEIRKLYPEGQLSHWVVFFWKCVVCVCFVLGRCSLLPVVNNSGAICNSWKLDPATLRFPLKGMLPYDKDLFEPQTGLLRYVLEQPYSRDMVCNMLGLNKQHKQRCTVLEDQLVDLVVYAMERSETEEQFDDGGTSQLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKNALGDFLPVMKLFDLLYPEKECIPVSDINKPQSTHAFAMTCIWIHLNRKAQNDNSKLQIPIPHSLKLHHEFLQQSLRNKSLPMTDYKIALLCNAYSTNSECFTLPMGVLVETIYGNGTQRISLPGTNCIACGSVTPLPMNLLDSLTVHAKMSLIHSIATRVIKLAHAKSSVALAPALVETYSRLLVYMEIESLGIKGFISQLLPNVFKCHAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLHSLAAVPQTNQNQLHLCVESTALRLITALGSSEVQPQFTRFLSDPKTVLSAESEELNRALILTLARATHITDFFTGSDSIQGTWCKDILQTIMNFTPHNWASHTLSCFPAPLQAFFKQNNVPQESRFNLKKNVEEEYRKWKSMTNENDIITHFSMQGSPPLFLCLLWKMLLETDHINQIGFRVLERIGARALVAHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLDRLILCLAMRSHEGNEAQVCYFIIQLLLLKPNDFRNRVSDFVKENAPEHWLQSDWHNKHMSYHKKYPEKLYFEGLAEQVNPPMQLQPQYLPIYFGNVCLRFLPVFDIVIHRFLELLPVSKSLETLLDHLGGLYKFHDRPVTYLYNTLHYYERHLRDRTNLKRKLVHAIMSSLKDNRTPGWCLSETYLKFGMNPRDDNVWIPDDTYYCKLIGRLHVLPMAGKSPGPFPNCDWRFNEFPNPAAHALHVTCVELMALAVPGKDVGNALLNVVLKRSECTCSVLQEPYWIVLHDRLVSVISSPVLTSEMDCVGYPFQLLDFTACHQSYSEMYCSYVLALAHAVWHHSSIGQLSLIPKFLSEVLKPLVKTEFQLLYIYHLVGPFLQRFQQERTRCMLEIGVAFYEMLQAVDHHSKHLAYMDPICDFLYHMKYMFTGDSVKDQVEKIICTLRPAMKLRLRFISKMEPAAAVATATSSSQPTMVSSPAPQSGPGPVQ
Length1320
PositionTail
OrganismAstyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Ostariophysi> Characiformes> Characoidei> Characidae> Astyanax.
Aromaticity0.10
Grand average of hydropathy-0.014
Instability index46.37
Isoelectric point7.91
Molecular weight151335.53
Publications
PubMed=25329095

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33644
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     140.38|      51|     126|     485|     572|       1
---------------------------------------------------------------------------
  495-  556 (55.73/94.61)	LLDSLTVhaKMsliHSIAT..RVIKLAHAKsSVALAPalvETYSRLLvYMEIESLGIKgFISQL
  572-  624 (84.65/36.31)	LLEMFSY..RM...HHIQPhyRVQLLSHLH.SLAAVP...QTNQNQL.HLCVESTALR.LITAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.87|      31|      53|    1189|    1222|       2
---------------------------------------------------------------------------
 1189- 1222 (44.89/35.56)	LKPLVKTEFQLLYIYhlVGPFLQRfQQERTRCML
 1245- 1275 (56.98/33.11)	MDPICDFLYHMKYMF..TGDSVKD.QVEKIICTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.19|      13|      18|     225|     237|       3
---------------------------------------------------------------------------
  225-  237 (25.15/14.33)	PYDKDLFEPQTGL
  245-  257 (26.04/15.09)	PYSRDMVCNMLGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     166.92|      42|     126|      54|      97|       4
---------------------------------------------------------------------------
   54-   97 (71.08/60.33)	F..LYDC.....L..............AMAVETSLLPPRMVCQALINSdsLEWERTQLWALTFKL
  107-  156 (33.06/19.59)	YkgVRDL.....LkavldkvqtipnlvSSAVVHQLLPVREVVEYI.....LDRNACLLPA.....
  178-  220 (62.78/45.64)	F..FWKCvvcvcF..............VLG.RCSLLPVVNNSGAICNS....W.KLDPATLRFPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     216.77|      62|      77|    1008|    1072|       7
---------------------------------------------------------------------------
 1008- 1072 (112.82/74.43)	PGWCLSETYLKFGMNPRDDNVWIPDDTYYCKLIGRLhVLPMAgkSPGPFPNCD...WRFNEFPNPAAH
 1087- 1151 (103.95/58.94)	PGKDVGNALLNVVLKRSECTCSVLQEPYWIVLHDRL.VSVIS..SPVLTSEMDcvgYPFQLLDFTACH
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33644 with Med23 domain of Kingdom Metazoa
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