<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33642

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMTEMFSSLYGQTDTQGPPGPSALGFGPGKPLAPPAAQNQVHMSVGIPHQLVDEGPPLRKPGAMNEPFYLLRELPVENELTGNTNLITHYNLEHAYNKFCGKKVKEKLSNFLPELPGMIDNPGLQDGSSLRSLIEKPPVCNNSFSPLTGAMLTGFRLHTGPLPEQYRLMHIQPPKKKSKHKHRHHRPQDPLPPETPSDSDHKKKKKKKDDDPDRKKKKKDKKKKKNRHSPDHPGMTGSQPSGSSLR
Length245
PositionHead
OrganismAstyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Ostariophysi> Characiformes> Characoidei> Characidae> Astyanax.
Aromaticity0.05
Grand average of hydropathy-1.080
Instability index49.77
Isoelectric point9.73
Molecular weight27307.96
Publications
PubMed=25329095

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364151
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP33642
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.99|      13|      18|     199|     211|       1
---------------------------------------------------------------------------
  199-  211 (24.85/11.35)	DHKKKKKKK.DDDP
  219-  232 (21.14/ 8.64)	DKKKKKNRHsPDHP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.77|      12|     114|     116|     130|       2
---------------------------------------------------------------------------
  116-  130 (19.98/15.97)	GMidnPGLQ.DGSSLR
  233-  245 (19.80/ 8.37)	GM...TGSQpSGSSLR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.41|      12|      37|      15|      27|       3
---------------------------------------------------------------------------
   15-   27 (21.30/13.89)	QGPP..GPSALGfGP
   53-   66 (21.11/ 8.60)	EGPPlrKPGAMN.EP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.11|      10|      26|     155|     164|       4
---------------------------------------------------------------------------
  155-  164 (20.08/ 9.52)	RLH..TGPLPEQ
  182-  193 (17.03/ 7.01)	RHHrpQDPLPPE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33642 with Med19 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AMLTGFRLHTGPLPEQYRLMHIQPPKKKSKHKHRHHRPQDPLPPETPSDSDHKKKKKKKDDDPDRKKKKKDKKKKKNRHSPDHPGMTGSQPSGSSLR
2) FLPELPGMIDNPGLQDGSSLRSLIEKPPVCNNSFSPLT
3) MFSSLYGQTDTQGPPGPSALGFGPGKPLAPPAAQNQVHMSVGIPHQLVDEGPPLR
149
110
4
245
147
58










Molecular Recognition Features






MoRF SequenceStartStop




1) DSDHKKKKKKKDDDPDRKKKKKDKKKKKNRHSPDHPGMT
2) QYRLMHIQPPKKKSKHKHRHHR
197
164
235
185