<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33635

Description Mediator complex subunit 14
SequenceMAPVQIGSDGQLVPVGGPTSAPQPPPAAPATQGVKLSVLIEFLLQRTYHEITLLAELKIEIVQFASRTRQLFVRLLALVKWASNAGKVEKLCCAMISAFLDQQAFLFVDTADRLASLARDALVHARLPSFAIPFAIDVLTTGSYPRLPTCIRDKIIPPDPITKAEKQTTLNQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDIPWRLLKLEILVEDKETGDGRALVHSMQVNYIHELVQSRLFADEKPLQDMYSCLHSFCLSLQLEVLHSQTLMLIRERWGDLVQVERYLPAKCLTLAVWNQQVLGRKTGTASVHKVSIKIDETDGSKPLQISHEPPLPACDSRLMERAMKIDHLSVEKLLIDSVHARSHQKLQELKAILKSSNPSDNSFIETALPTLVIPILEPCGRSECLHIFVDLHSGMFQPMLYGIDQSMLDDIEKTINDDMKRIVTWLQQLKFWLGEQRCRQSVKHLPTLCTDTLHLSNSASHPVGSLSKHRLFIKLTRLPQYYIVVEMFDVANSSTELQYKYYFLSVSQLEGEDGLPCALLLQQFKPNLEELVQDLSSGRMLRPGTKRKLSGEQGATEPKKPKRSGEMCAFNKELAHLVAMCDTNMPLIGLRSELSNMEIPHQGVQVEGDGCSHAIRLLRVPPAKGVSEETRKALDRTLLDCTFRLQGRNNRTWVAELVFTSCPLNSTSTKEQASTRHVYLTYENPLSEPVGGRKVVEMFLNDWNSISQLYECVLDFSRALPEMPSFLSLFSEIRLYNYRKLVLCYGNTKGSSVTIQWNSVTQRFHLALGTVGPNSGCSNCHNIILHQLQEMFNKTPNVVQLLQVLSDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSPTHIRLAFRNMYCIDIYCHSRGVVAIRDGAYSLFDNTKIVEGFYPAPGLKVKNFNTPNWIPLLKVYISAIHVIFFLRRSVNEDDNPPSPVGVDVMDTLMPHMQPQQPIRGQGVYPPLTSPPNSYHGNVAPSPSMMPTQSPGNIHAANSPSGALRAPSPFGPTPSPSSLGISMGQTSNFASPHGALDPSSPYPMVSPSQRTGTWPGSPQVSGPSPGARIHGMSPGNPSLHSPIPDASHSPRAGTSSQVMPTSMPPPRKLPQRSWAASIPTILTHNALHVLLLPSPTMCVVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQLEQNLTIVNSNEPGVIMFKTEVLKCRVALNPKSYQTLQLKVTPENAGPWSQEELQVLEKFFETRVAGPPFKYNTLNAFTKLLGAPTNILRDCVRIMKLELFPEQAAQLKWNVQFCLTIPPSAPPIAPPGTIAVVLKTKMLFFLQLTQRLPVPQEPISIIVPIVYDMATGLTQQADIPRQHSSSGAAALMVSSILRRFNEHHPARPGECTIFASVHELMANLTLNSGGRP
Length1436
PositionTail
OrganismAstyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Ostariophysi> Characiformes> Characoidei> Characidae> Astyanax.
Aromaticity0.07
Grand average of hydropathy-0.130
Instability index50.69
Isoelectric point8.69
Molecular weight159302.62
Publications
PubMed=25329095

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
blood vessel morphogenesis	GO:0048514	IEA:Ensembl
embryonic viscerocranium morphogenesis	GO:0048703	IEA:Ensembl
neural crest cell differentiation	GO:0014033	IEA:Ensembl
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro
stem cell population maintenance	GO:0019827	IEA:Ensembl
ventricular system development	GO:0021591	IEA:Ensembl

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP33635
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     184.70|      30|      30|    1018|    1047|       1
---------------------------------------------------------------------------
 1000- 1028 (41.63/22.04)	GV..YP.....PLTSP......PNSYhgnvaPS.PS.M...MPTQSP
 1029- 1060 (46.53/25.77)	GN..IH.....AANSPSGALRAPSPF..gptPS.PS.S...LGI.SM
 1061- 1088 (41.22/21.73)	GQ..TS.....NFASPHGALDPSSP........yPM.V...SPSQRT
 1089- 1111 (31.92/14.66)	GT..WP.....GSPQVSG....PSP.............garIHGMSP
 1112- 1141 (23.40/ 8.18)	GNpsLHspipdASHSPRAG..TSS............qV...MPTSMP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     233.66|      79|     282|     571|     665|       2
---------------------------------------------------------------------------
  571-  665 (122.66/112.28)	PNLEELVQDLSSGR.............MLrpG.TKRKLSGEQG.ATEPKKPkrsgemcafnkelAHlVAMCDTNMPLIGLR..............SELSNMEI.....PHQGVQVEGDGCSHAIRLLRV
  841-  953 (111.00/69.52)	PNVVQLLQVLSDTQaplnainklptvpML..GlTQRTNTAYQCfSILPQSP.............TH.IRLAFRNMYCIDIYchsrgvvairdgaySLFDNTKIvegfyPAPGLKVKNFNTPNWIPLLKV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     230.82|      64|     831|     474|     541|       6
---------------------------------------------------------------------------
  474-  541 (105.12/68.34)	LKFWLGEQRcrqSVKHLPTLCTdTLHLSNSASHPVGSL.......SKHRLFIKLT.RLP....QYYIVVEM.F.DVANSSTE
  725-  753 (33.47/11.89)	........................LTYENPLSEPVGGR.......K.....................VVEM.FlNDWNSISQ
  755-  783 (41.36/17.73)	YECVLDFSR...ALPEMPSF.................L.......S...LFSEI..RLY....NY.................
 1321- 1379 (50.87/22.84)	...................FCL.TIPPSAPPIAPPG..tiavvlkTKMLFFLQLTqRLPvpqePISIIVPIvY.DMATGLTQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     165.10|      48|     149|     273|     321|       7
---------------------------------------------------------------------------
  273-  321 (82.23/62.73)	CLHSFCLSLQLEvLHSQTL..MLIRERWGDLVQVERYLPAKCLTLAVWNQQ
  424-  473 (82.88/58.51)	CGRSECLHIFVD.LHSGMFqpMLYGIDQSMLDDIEKTINDDMKRIVTWLQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.03|      14|      37|    1230|    1243|      11
---------------------------------------------------------------------------
 1230- 1243 (25.95/20.17)	LKCRVALNPKSYQT
 1268- 1281 (27.08/21.47)	FETRVAGPPFKYNT
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33635 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) NPPSPVGVDVMDTLMPHMQPQQPIRGQGVYPPLTSPPNSYHGNVAPSPSMMPTQSPGNIHAANSPSGALRAPSPFGPTPSPSSLGISMGQTSNFASPHGALDPSSPYPMVSPSQRTGTWPGSPQVSGPSPGARIHGMSPGNPSLHSPIPDASHSPRAGTSSQVMPTSMPPPRKLPQRSWA
973
1152










Molecular Recognition Features






MoRF SequenceStartStop




NANANA