<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33633

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMSACFVPNGASLEDCHSNLFYLADLTGIKWKGYVWQGPTSAPMLFPVTEEDPILSSFSRCLKADVLSVWRRSQRQGRRELWLFWWGEDPIFSELIHSELTGEDDGVWESGLSYECRTLLFKAIHNLLERCLMNRSFVRLGKWFVKPYEKDEKPINKSEHLSCSFSFFLHGDSNVCTSVEINQHQPVYHLSEEHLTLAQQASSPFQVILSPFGLNGTLTGQSFKLSDPPTQKLIEEWKQFYPISTSSKESTEDKMEDIDWEDDSLAAAEVLVGGVRMVYPACMVLVPQADIPTITPVGSSHCTAVYSGGHQVPASNRDPAISSVTLTPPTSPEEAQTVDSLTAQKWMRLPSAVDGFSVDSASHHGGKIPRRMASQVVERVWQECNMNRSLNKRKFSATGSGTSEEEVMEKMGSWDFVESVQRTTCNCSRHKTLKQRVGGAQGQPVSTGQVQQQPIKHKAGEKLDKGDKQQKRPQTPFHHRSSVSDDISMEADASASQRLALRGQECGRFTGLHPAEVCTVPKPPLLHTGELVGSPQPPPLSPHPCDRVEEGSETLKNLSTPHSQHFYPTPSEPCLLPQKGPDDPCADSLAHPFHPAYSEATEPTVYIGTAVCLENDGNHMPWRFFNLPRRKDLDLPTPSLPTDKLKEEGLMGVNGNVSITEVMAISKHTLKVSGERVQTYLQRRNQHLAAAIADSDLEPEVDPYAFVDGDVKFTFSDKKDKAGIEREQGRKHKVRAFVTVLSITTSLITSNIDAQRGAAHKTASSTSLIHDSDLTVSFKDLDNLFNSDEDEQTPGARRAVNGTDDKFGSKEPKTAMLDPVSCISSADLNQIFPTPPSLEPHIMGYSPMNMGGKEYGNMEPGPGMTSLDGSSALVSQFKIEVEESFCSPKPSEIKDFSFVYKPELCQAFVGCSMFAPLKTLPSQCLPPIRLLEECVYRPSWSVGKLELLNPIPAMNFLNRDSAMEQDYNQSYTPQTHTPFISNSAPPSNSGTGILPSPATPRFSAPTPRTPRTPRTPRGPSSVQGSLKYENSDLYSPASTPSTCRPLNSVEPATVPSIPEAHSLFVTLILSESVMNLFKDCNFDSCCICVCNMNIKGADVGVYINDPNMEAQYPCSCGFSAVVNRRYGNGSGLFLEDELDIIGRGSDVSREAEKRFEALRSTSLEKSPGGLQDRNPDELILLLQDQCTNPFPPLVAAEPEGTASGAPGSSVVPPCVRVEERDFHNDCYLALEHGRQFMDNMSGGKVDEVLVKSTCLHHWAKCNVDVSALCSQDVLRVLLSLQPVLQDAIQKKRTVRSWGVQGPLTWQQFHKMAGRGSYGTDESPEPLPIPTFLVGFEYDFVVLSPFGLPYWEKLLLEPFGSQRDMGYLVLCPENEALINGAKSFFRELTAVYESCKLGQHRPISKVHADGIVRVGGAAAKKLSEQPISDWFLKGVCSTTEAFAKLKLFAQFCRHDLAPYLATQPLDSSLLTQPSPASYTTQTLPAQSSGSASSNPQSSLASGVSSLTSNTGTGNVGQGLQGSTSSMPSSGPQNGSVQPSKPSSFPPFGGMGVQSNSSQSGALGQQAGSQSSNLSGDNSSSSSQTQGSSEPPESTMEREKVGVPTDGESHAIVYPPAIMIYIVDTFSYEDAETGVAHSSVWTLGLLRCYLEMVQFLPPHIRNSISVQIIPCQYLLQPVKSEERQLYAQHLKSLAFSVFSQCRRPLPASTNVKSLTGFGPGLALDTALRSPERPECLRMYTPPFILAPVKDKQTELGETFGEASQKYNVLFVGYCLSHDQRWLLATCTDMYGELLETCIINIDVPNRARRKKGSARRLGLQKLWEWCLGLVQMTSVPWRVVIGRLGRIGHGELRDWSILLSRRNLQSLSRRLKDMCRMCGISSADTPSILSACLVAMEPQGSFIIMPDSVSTGSVFGRSTTLNMQTSQLSTPQDTSCTHILVFPTSAFVQVNSSSYTPEDIAFNPINDGSDPIGGIFDLLEQESDLVDPDIISILPASPTTSPVHSPGSQYHHGGDGSKGQSTDRMESHDEAPNILQQPLALGYFVSTAKAGPLPDWFWSACPQAQNQCPLFLKASLHIHVSSVQSDELLHGKHSHPLDSSQTSDVLRFVLEQYNALSWLTCDPATQDRRSCLPIHFVVLNQLYNFIMNML
Length2147
PositionMiddle
OrganismAstyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Ostariophysi> Characiformes> Characoidei> Characidae> Astyanax.
Aromaticity0.07
Grand average of hydropathy-0.346
Instability index54.06
Isoelectric point5.63
Molecular weight235571.38
Publications
PubMed=25329095

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33633
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     171.78|      33|      37|    1479|    1511|       1
---------------------------------------------------------------------------
  968-  991 (27.78/ 8.36)	...........QSYTPQthTPFISN.SAPPSNSGTG
 1479- 1511 (56.84/25.77)	QTLP.AQSSGSASSNPQ..SSLASGVSSLTSNTGTG
 1515- 1549 (55.63/25.04)	QGLQ.GSTSSMPSSGPQngSVQPSKPSSFPPFGGMG
 1556- 1582 (31.52/10.60)	QSGAlGQQAGSQSSN.L..SGDNSSSSSQT......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.86|      22|      37|     534|     568|       2
---------------------------------------------------------------------------
  526-  553 (36.18/20.24)	HTGELVGSPQPPPLSPH.....PCdrveegSET
  561-  587 (39.68/22.56)	HSQHFYPTPSEPCLLPQkgpddPC......ADS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     135.36|      34|      36|      50|      83|       3
---------------------------------------------------------------------------
   23-   45 (20.35/ 7.15)	..............ADLTGIkWKGYVWQGpTSAPMLF
   50-   83 (61.47/38.22)	EDPILSSFSRC.LKADVLSV.WRRSQRQG.RRELWLF
   87-  120 (53.54/32.23)	EDPIFSELIHSeLTGEDDGV.WESGLSYE.CRTL.LF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.99|      12|      37|     993|    1004|       4
---------------------------------------------------------------------------
  993- 1004 (24.70/11.58)	LPSPA.TPRFSAP
 1032- 1044 (21.29/ 8.86)	LYSPAsTPSTCRP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     150.00|      45|     705|    1298|    1349|       5
---------------------------------------------------------------------------
 1298- 1349 (73.53/64.88)	VQGPLTwqQFHKmAGRGSYGT........DESPEPLPIPTFLvGFeydFVVLSPFG.LPYW
 2000- 2053 (76.47/43.53)	VHSPGS..QYHH.GGDGSKGQstdrmeshDEAPNILQQPLAL.GY...FVSTAKAGpLPDW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.88|      29|      36|     883|     916|       6
---------------------------------------------------------------------------
  883-  916 (42.87/46.68)	SFCSPkPSEIKDfSFVYKPELCqafVG.CSMFAPL
  921-  950 (51.01/33.65)	SQCLP.PIRLLE.ECVYRPSWS...VGkLELLNPI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.64|      20|      36|     746|     765|       7
---------------------------------------------------------------------------
  746-  765 (32.27/17.44)	LITSNIDAQRGAAHKTASST
  783-  802 (34.38/19.04)	LFNSDEDEQTPGARRAVNGT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.37|      14|      36|    1417|    1430|       8
---------------------------------------------------------------------------
 1417- 1430 (25.40/15.11)	AKKLSEQPISDWFL
 1455- 1468 (23.97/13.79)	APYLATQPLDSSLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.58|      16|     973|     424|     439|       9
---------------------------------------------------------------------------
  424-  439 (31.44/18.86)	CNCSRHKTLKQ.......RVGGA
 1393- 1415 (24.13/12.69)	CKLGQHRPISKvhadgivRVGGA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     126.97|      39|     705|    1139|    1209|      10
---------------------------------------------------------------------------
  485-  524 (67.51/18.58)	DISMEADA..SASQRLALRgQECGRFTGLHPAEV.......CTVPKPPL
 1145- 1192 (59.46/57.42)	DVSREAEKrfEALRSTSLE.KSPGGLQDRNPDELilllqdqCTNPFPPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.87|      16|     415|     220|     235|      11
---------------------------------------------------------------------------
  220-  235 (29.16/17.06)	QSFKLSDP..PTQKLIEE
  630-  647 (24.71/13.10)	KDLDLPTPslPTDKLKEE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.40|      26|     415|    1654|    1716|      12
---------------------------------------------------------------------------
  141-  167 (44.58/ 8.34)	KWFVKPYEKDEKPINkSEHLSC.SFSFF
 1669- 1695 (39.82/38.97)	QYLLQPVKSEERQLY.AQHLKSlAFSVF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     119.14|      34|     703|    1062|    1098|      14
---------------------------------------------------------------------------
 1062- 1098 (59.10/45.94)	LFVTLILSESVMNLFKDC.NFDSCCICVCNMNIkgaDV
 1766- 1800 (60.04/38.53)	LFVGYCLSHDQRWLLATCtDMYGELLETCIINI...DV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.64|      19|      36|     355|     373|      15
---------------------------------------------------------------------------
  355-  373 (33.20/18.62)	FSVDSASHHGGKIPRRMAS
  394-  412 (31.44/17.23)	FSATGSGTSEEEVMEKMGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.06|      15|     124|     170|     185|      18
---------------------------------------------------------------------------
  170-  185 (26.06/21.49)	GDSNvCTSVEINQHQ.P
  297-  312 (27.00/16.82)	GSSH.CTAVYSGGHQvP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.81|      17|     697|    1193|    1209|      19
---------------------------------------------------------------------------
 1193- 1209 (30.73/15.90)	VAAEPEGTASGAPGS....SV
 1891- 1911 (27.08/13.09)	VAMEPQGSFIIMPDSvstgSV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33633 with Med13 domain of Kingdom Metazoa
Unable to open file!