<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33630

Description Uncharacterized protein
SequenceMSTSGGPSAGGSGGTLPALLMANGGGGKLSSINSNSSISKPDVKPSLGGTTGGPGSKVLLGGDKHETWQMELLMERLRTKAKSAQYKSFPEMSKSVRMSLLEKRYALDAVEKSNLQKTLDSMQYCIKVTTRQGLVERLDCLTRQLGLKLSEDTSGLFISSDMFYLEIILDPLLGTVQDVKVHHECKMKQQSCSELVACLQRGDFADFTTQLEGLASIYQLNAEKKIKVNAFVALQALETDLHTLYTLTANRYTEIHSLLLQSPLGVLQKRRGGHPMRLTYFVPPYELLDSATRTMNVLSAELIARERIGCSVTVVLEAASANKLQIQPLLIPGAGAGSTGGGGTGTGSTPTYAAIEKHNSTSLPATFVLRLSKPIPIDGAMMSAIRTVVGRSEGSDESSTAAGTRNTSLMGLIAQHASGGTVQDLSRGLPVTLPDQYHCYYLTDNPSLRGVMVGSIPFTEPQHVPKLLVYLRRAAVFNQLLASCIRNTSTSTSVSTSGTMPGTGTELPAQIPLVFEVTALSCDYITVSLMHPYEESLATVEFDLQNIANIVVHVYCGEGDGTSGDDGRTAEAAEHISTVLQRCMSIPVTLRALVRYWKEQQEQKFKRNGTVGGAGSAGTTSAAGPGGPDGGAGGGSGLGSSTPDDSNGFPSLSLGPPSVESGSNGGTNGAGANGAGSSANGTLNGTGLSALTLHQQHQQMLLQQQQQQRPSAGGTMMNGLAANGFGLLASSLGTGMEGFCDILTAAAAGTTTTTGARNGGPTGIGDAVGSMQMAGLREPPDALTGGATKKRRLNEDFCKSPKSDSNHGTAVGGGTEDTTHSNINSNSNNSTHASGGAGGVATVAAVAAAAAAALLDEVQRAGAGGAIGGTEEDVGRRMAALLGGESGNANGTDSGCSLGEQQQLQQQQHNRTTEKPQPQSNSNHPPSATPPLPSSLASGSSASAGNSGGAAAAAAAAAAVAALLDDTDKSRRMAAGTLLLESLNFPSGPELPGSGLDGGRKRKRSSSSSSSSSSSSSSSSSSSSSSSSSDAEEEETVDLVEAEMSSFFAESASTLAVTMATTTALVTAMATTTATAVTPSINAAATVASVGAGGGGPQAKVATLAASGQGKPPPTTLAMAIGSTGKPSILPTALSGMIEEKRPAGGAMLAGGLEIIPLATNVGATSIAPAVATSPTVTPPPSSTTTLKKSSSSSSGTGSGSSSSGSSSSSSHRKTGDSGERGKPEKKKKRKAEEGLMAAAATAAAMGPPNKIPLLKSGESSPSHRKASPKHSATSPVHHSSPKHGSGGLGFHSPKHGTGSTGSSPKHLTGGVGGSGAGMSGGGGKPSMSALKSAAATTGSSPKASSSAGGDLSLIGSVSAGSSSSSSSKERGADKDHRAEKKALQFSGSGSSSSLSVSSGVGGVGAGGRSKNATMKQLKQLDLSISVDGGGGGSPATIDLTGSPTSSGGITTSLGLGTGSIAAANMLQALQAAKHQRGTSKSISQQQQQQQQQQQQHGGGALSAVIDKLKSAQSTDGEDGAVLVLPEMTITQQTQPSSMATGTSVNIGSFGALSGPGAGSSAITLKDVTKAGLLSSSSTSSSSSSASLTNCASLGINSASQSPSMTSASGKASEYMVKPSSDGIKLTIQNKKGSKSSSSSSSSSKGGTGGGSGSSKTGLKPGVSSGPISSKQQHQQQQQQQQQSLQNHTTSFSGAFPSSTKSGHGSPHYTSSTSSSSSKAPFQKSNSFGSLSGSSGGGSGSGGVLKASSKVSSPKSTSNPGNSSSYASSKDKSSGGRLGSSKSSSTLGLSATGTTGGSTSLVNPISIMKMLGYPTNASADGFAKTLDTKFQIPKLSARTANAQSGNDGANEERTTKERGGSSTVAGTKEASAAASRKQKQQQSSSVGGGGGAGGSGTGAGTMRPFAPSPSGSSNDGTNASTPTNTNSARLLSDLLGAGAVGGLKTAGKGTSAGTGGIEGNVSPLHPLLPNIVQKMFGNESSGSSVPAAAAAASTAAGAGSMMSHKSNSSDGSMFPGGSAAAGLLANMRSGSAPSTPTTTTAAAAAAPSVLPPYPSPVANDSGGVANDLLSALMRPPSRPSITLSNHSHIAQDGAVDGAGLASMLMMAGSGGTAAAGLVGLDGATNTQQLMAALKSVAAAGSTVGNAAERNHLTNHHNHLQSNHHHTNHHVTSPASVSVHIVKSPAPSPLPFASPHGGGGAGSAGGPGGIDDDMLDEALIGIGSK
Length2224
PositionMiddle
OrganismAnopheles darlingi (Mosquito)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.03
Grand average of hydropathy-0.303
Instability index50.62
Isoelectric point9.16
Molecular weight221017.27
Publications
PubMed=20920257
PubMed=23761445

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33630
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|    1891.86|     334|     334|    1255|    1588|       1
---------------------------------------------------------------------------
  666-  813 (182.95/29.89)	........................GTNGAGA.NG....A....................................GS..SANG...TLN.GTG.....................LS.AL....T........LHQQHQQMllQQQQQQRpsaG..G....T...........................................MMN.....GLAAN..GFGLL..............................................................ASSL..........................GTGMEGF..CDILTAAAAGTTT..TTGARNGGPTGIGDAVGSMQMAG..LREPPdALTGGATK.KRRLN..EDF..............CKSPKSDS.NHGTAVGG
  814- 1035 (309.32/55.84)	GTEDTTHS..NINSNSNNSTHASGGAGGVAT.VAAVAAAAAAAL..LD.EVQRAGA..GGAIGGTE.ED.....VGRR.....MAALLGGESGN.............................AN..GTDSGCSLGEQQQ..LQQQQHN...R..TT..........EKPQPQSNSNHPPSAT....PPL...........PSSLAS.....GSSASAGNSGGAAAAAAAAAAV....................AALL...........................DDTDKS...RRMAAGTLLLESLNFP.SGPEL...............................PGSGLDGGRKR...............KRSSSSSSSS.......S..SSSSS......SSSSSSSSSSSDAEEEE
 1041- 1377 (424.72/79.53)	EAEMSSF...FAESASTLAVTMATTTALVTAmATTTATAVTPSINAAATVASVGAG..GGGPQAKVaTL.....AASGQGKPPPTT.LAMAIGST......GKPS........ILPtALSGmIEEKRPA.......................G..GAMLAGG....LEIIPLATNV....GATSI.APAVatspTVT..PPPSSTTTlkkssSSSSGTGSGSSSSGSSSSSSHRKTGDSgergkpekkkkrkAEEGLMAAAATAAAmgpPNKIPL.......LKSGESSPS...HRKASPKHSATSPVHH.SSPKHGSGGLGFH.SPKHGTGSTGSSPKHLTGGVGGSGAGMSGGGGKPSMSA..LKSAA.ATTGSSPKASSSAG..GDLSLIGSVSA......GSSSSSSSKERGADKDH
 1378- 1674 (411.20/76.75)	RAEKKALQ..FSGSGSSSSLSVSSGVGGVGA.GGRSKNATMKQLKQLDLSISVDGG..GGGSPATI.DL.....TGSPTSSGGITTSLGLGTGSI......AAAN........MLQ.ALQA.AKHQRGTSKSISQQQQQQ..QQQQQQH...G..GGALSAV....IDKLKSAQSTDGEDGAVLV.LPEM....TITQQTQPSSMAT.....GTSVNIGSFGALSGPGAGSSAITLKDV.............TKAGLLSSSSTSSS...SSSASLtncaslgINSASQSPS...MTSASGKASE....YM.VKP..SSDGIKLTiQNKKGSKSSSSSSSSSKGGTGG.GSGSSKTGLKPGVSSgpISSKQ.QH................................................
 1722- 1965 (288.66/51.60)	..........FQKSNSFGSLSGSSG.GGSGS.GGVLKAS.....................................SKVSSPKSTSNPG.NSSSY......ASSK.............DKS.SGGRLGSSKSSSTLGLSA..T.........GttGGSTSLVnpisIMKMLGYPTNASADGFA......K....TLDTKFQIPKLSA.....RTA......NAQSGNDGANEERTTKE.........................RGG...SSTVAG.......TKEASAAAS....RKQKQQQS..SSVG.......GGGGAG.....GSGTGAGTMRP......FAPSPSGSSNDG................TNASTPTNTNSARllSDLLGAGAVGGlktagkGTSAGTGGIEGNVSPLH
 1966- 2223 (275.03/48.80)	PLLPNIVQkmFGNESSGSSVPAAAAAASTAA.GAGS....MMSHK....SNSSDGSmfPGGSAAA..GLlanmrSGSAPSTPTTTTAAAAAAPSVlppypsPVANdsggvandLLS.AL.....MRPPSRPSITLSNHSH..IAQDGAV...D..GAGLASM.......LMMAGS.GGTAAAGLVgLDGA....TNTQQL....MA................AL............KSV.............AAAG....STVGNA...AERNHL................tnhHNHLQSNHHHTN..HHvTSP....ASVSVH.IVK....SPAPSPLPFASPHGGGGAGSAGGPGGIDDDM..LDEAL.IGIGS.............................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     119.64|      34|     290|     332|     368|       2
---------------------------------------------------------------------------
  332-  368 (56.32/27.23)	PGaGAGSTGGGGTGTG.STPTYAaiEKHNSTSLPATFV
  625-  659 (63.32/23.70)	PG.GPDGGAGGGSGLGsSTPDDS..NGFPSLSLGPPSV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33630 with Med1 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AAAAAAVAALLDDTDKSRRMAAGTLLLESLNFPSGPELPGSGLDGGRKRKRSSSSSSSSSSSSSSSSSSSSSSSSSDAEEEETVDLVEAE
2) ATVASVGAGGGGPQAKVATLAASGQGKPPPTTLAMAIGSTG
3) AVGGLKTAGKGTSAGTGGIEGNVSPLHPLLPNIVQKMFGNESSGSSVPAAAAAASTAAGAGSMMSHKSNSSDGSMFP
4) DGEDGAVLVLPEMTITQQTQPSSMATGTSVNIGSFG
5) EVQRAGAGGAIGGTEEDVGRRMAALLGGESGNANGTDSGCSLGEQQQLQQQQHNRTTEKPQPQSNSNHPPSATPPLPSSLASGSSASAGNSGGAAA
6) FAKTLDTKFQIPKLSARTANAQSGNDGANEERTTKERGGSSTVAGTKEASAAASRKQKQQQSSSVGGGGGAGGSGTGAGTMRPFAPSPSGSSNDGTNASTPTNTNSARLLSDLLG
7) GSTVGNAAERNHLTNHHNHLQSNHHHTNHHVTSPASVSVHIVKSPAPSPLPFASPHGGGGAGSAGGPGGIDDDMLDE
8) KFKRNGTVGGAGSAGTTSAAGPGGPDGGAGGGSGLGSSTPDDSNGFPSLSLGPPSVESGSNGGTNGAGANGAGSSANGTLNGTGLSALTLHQQHQQMLLQQQQQQRPSAGGTMMNGL
9) LANMRSGSAPSTPTTTTAAAAAAPSVLPPYPSPVANDS
10) LQALQAAKHQRGTSKSISQQQQQQQQQQQQHGGGALSAVIDKLK
11) NCASLGINSASQSPSMTSASGKASEYMVKPSSDGIKLTIQNKKGSKSSSSSSSSSKGGTGGGSGSSKTGLKPGVSSGPISSKQQHQQQQQQQQQSLQNHTTSFSGAFPSSTKSGHGSPHYTSSTSSSSSKAPFQKSNSFGSLSGSSGGGSGSGGVLKASSKVSSPKSTSNPGNSSSYASSKDKSSGGRLGSSKSSSTLGLSATGTTGGSTSLVNPISIMKM
12) SIAPAVATSPTVTPPPSSTTTLKKSSSSSSGTGSGSSSSGSSSSSSHRKTGDSGERGKPEKKKKRKAEEGLMAAAATAAAMGPPNKIPLLKSGESSPSHRKASPKHSATSPVHHSSPKHGSGGLGFHSPKHGTGSTGSSPKHLTGGVGGSGAGMSGGGGKPSMSALKSAAATTGSSPKASSSAGGDLSLIGSVSAGSSSSSSSKERGADKDHRAEKKALQFSGSGSS
13) SLSVSSGVGGVGAGGRSKNATMKQLKQLDLSISVDGGGGGSPATIDLTGSPTSSGGITTSL
14) SSINSNSSISKPDVKPSLGGTTGGPGSKVLL
15) TTTTTGARNGGPTGIGDAVGSMQMAGLREPPDALTGGATKKRRLNEDFCKSPKSDSNHGTAVGGGTEDTTHSNINSNSNNSTHASGGAGGVAT
954
1085
1939
1516
857
1822
2140
604
2024
1467
1590
1166
1394
30
750
1043
1125
2015
1551
952
1936
2216
720
2061
1510
1810
1392
1454
60
842










Molecular Recognition Features






MoRF SequenceStartStop




1) DKDHRAEKKALQF
2) EKKKKRKAEEGLMAAAATA
3) LIGIGSK
4) MSALKSAA
5) NKIPLLKS
6) TMRPF
7) VATLA
1374
1225
2218
1328
1250
1901
1101
1386
1243
2224
1335
1257
1905
1105