<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33630

Description Uncharacterized protein
SequenceMSTSGGPSAGGSGGTLPALLMANGGGGKLSSINSNSSISKPDVKPSLGGTTGGPGSKVLLGGDKHETWQMELLMERLRTKAKSAQYKSFPEMSKSVRMSLLEKRYALDAVEKSNLQKTLDSMQYCIKVTTRQGLVERLDCLTRQLGLKLSEDTSGLFISSDMFYLEIILDPLLGTVQDVKVHHECKMKQQSCSELVACLQRGDFADFTTQLEGLASIYQLNAEKKIKVNAFVALQALETDLHTLYTLTANRYTEIHSLLLQSPLGVLQKRRGGHPMRLTYFVPPYELLDSATRTMNVLSAELIARERIGCSVTVVLEAASANKLQIQPLLIPGAGAGSTGGGGTGTGSTPTYAAIEKHNSTSLPATFVLRLSKPIPIDGAMMSAIRTVVGRSEGSDESSTAAGTRNTSLMGLIAQHASGGTVQDLSRGLPVTLPDQYHCYYLTDNPSLRGVMVGSIPFTEPQHVPKLLVYLRRAAVFNQLLASCIRNTSTSTSVSTSGTMPGTGTELPAQIPLVFEVTALSCDYITVSLMHPYEESLATVEFDLQNIANIVVHVYCGEGDGTSGDDGRTAEAAEHISTVLQRCMSIPVTLRALVRYWKEQQEQKFKRNGTVGGAGSAGTTSAAGPGGPDGGAGGGSGLGSSTPDDSNGFPSLSLGPPSVESGSNGGTNGAGANGAGSSANGTLNGTGLSALTLHQQHQQMLLQQQQQQRPSAGGTMMNGLAANGFGLLASSLGTGMEGFCDILTAAAAGTTTTTGARNGGPTGIGDAVGSMQMAGLREPPDALTGGATKKRRLNEDFCKSPKSDSNHGTAVGGGTEDTTHSNINSNSNNSTHASGGAGGVATVAAVAAAAAAALLDEVQRAGAGGAIGGTEEDVGRRMAALLGGESGNANGTDSGCSLGEQQQLQQQQHNRTTEKPQPQSNSNHPPSATPPLPSSLASGSSASAGNSGGAAAAAAAAAAVAALLDDTDKSRRMAAGTLLLESLNFPSGPELPGSGLDGGRKRKRSSSSSSSSSSSSSSSSSSSSSSSSSDAEEEETVDLVEAEMSSFFAESASTLAVTMATTTALVTAMATTTATAVTPSINAAATVASVGAGGGGPQAKVATLAASGQGKPPPTTLAMAIGSTGKPSILPTALSGMIEEKRPAGGAMLAGGLEIIPLATNVGATSIAPAVATSPTVTPPPSSTTTLKKSSSSSSGTGSGSSSSGSSSSSSHRKTGDSGERGKPEKKKKRKAEEGLMAAAATAAAMGPPNKIPLLKSGESSPSHRKASPKHSATSPVHHSSPKHGSGGLGFHSPKHGTGSTGSSPKHLTGGVGGSGAGMSGGGGKPSMSALKSAAATTGSSPKASSSAGGDLSLIGSVSAGSSSSSSSKERGADKDHRAEKKALQFSGSGSSSSLSVSSGVGGVGAGGRSKNATMKQLKQLDLSISVDGGGGGSPATIDLTGSPTSSGGITTSLGLGTGSIAAANMLQALQAAKHQRGTSKSISQQQQQQQQQQQQHGGGALSAVIDKLKSAQSTDGEDGAVLVLPEMTITQQTQPSSMATGTSVNIGSFGALSGPGAGSSAITLKDVTKAGLLSSSSTSSSSSSASLTNCASLGINSASQSPSMTSASGKASEYMVKPSSDGIKLTIQNKKGSKSSSSSSSSSKGGTGGGSGSSKTGLKPGVSSGPISSKQQHQQQQQQQQQSLQNHTTSFSGAFPSSTKSGHGSPHYTSSTSSSSSKAPFQKSNSFGSLSGSSGGGSGSGGVLKASSKVSSPKSTSNPGNSSSYASSKDKSSGGRLGSSKSSSTLGLSATGTTGGSTSLVNPISIMKMLGYPTNASADGFAKTLDTKFQIPKLSARTANAQSGNDGANEERTTKERGGSSTVAGTKEASAAASRKQKQQQSSSVGGGGGAGGSGTGAGTMRPFAPSPSGSSNDGTNASTPTNTNSARLLSDLLGAGAVGGLKTAGKGTSAGTGGIEGNVSPLHPLLPNIVQKMFGNESSGSSVPAAAAAASTAAGAGSMMSHKSNSSDGSMFPGGSAAAGLLANMRSGSAPSTPTTTTAAAAAAPSVLPPYPSPVANDSGGVANDLLSALMRPPSRPSITLSNHSHIAQDGAVDGAGLASMLMMAGSGGTAAAGLVGLDGATNTQQLMAALKSVAAAGSTVGNAAERNHLTNHHNHLQSNHHHTNHHVTSPASVSVHIVKSPAPSPLPFASPHGGGGAGSAGGPGGIDDDMLDEALIGIGSK
Length2224
PositionMiddle
OrganismAnopheles darlingi (Mosquito)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.03
Grand average of hydropathy-0.303
Instability index50.62
Isoelectric point9.16
Molecular weight221017.27
Publications
PubMed=20920257
PubMed=23761445

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33630
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|    1891.86|     334|     334|    1255|    1588|       1
---------------------------------------------------------------------------
  666-  813 (182.95/29.89)	........................GTNGAGA.NG....A....................................GS..SANG...TLN.GTG.....................LS.AL....T........LHQQHQQMllQQQQQQRpsaG..G....T...........................................MMN.....GLAAN..GFGLL..............................................................ASSL..........................GTGMEGF..CDILTAAAAGTTT..TTGARNGGPTGIGDAVGSMQMAG..LREPPdALTGGATK.KRRLN..EDF..............CKSPKSDS.NHGTAVGG
  814- 1035 (309.32/55.84)	GTEDTTHS..NINSNSNNSTHASGGAGGVAT.VAAVAAAAAAAL..LD.EVQRAGA..GGAIGGTE.ED.....VGRR.....MAALLGGESGN.............................AN..GTDSGCSLGEQQQ..LQQQQHN...R..TT..........EKPQPQSNSNHPPSAT....PPL...........PSSLAS.....GSSASAGNSGGAAAAAAAAAAV....................AALL...........................DDTDKS...RRMAAGTLLLESLNFP.SGPEL...............................PGSGLDGGRKR...............KRSSSSSSSS.......S..SSSSS......SSSSSSSSSSSDAEEEE
 1041- 1377 (424.72/79.53)	EAEMSSF...FAESASTLAVTMATTTALVTAmATTTATAVTPSINAAATVASVGAG..GGGPQAKVaTL.....AASGQGKPPPTT.LAMAIGST......GKPS........ILPtALSGmIEEKRPA.......................G..GAMLAGG....LEIIPLATNV....GATSI.APAVatspTVT..PPPSSTTTlkkssSSSSGTGSGSSSSGSSSSSSHRKTGDSgergkpekkkkrkAEEGLMAAAATAAAmgpPNKIPL.......LKSGESSPS...HRKASPKHSATSPVHH.SSPKHGSGGLGFH.SPKHGTGSTGSSPKHLTGGVGGSGAGMSGGGGKPSMSA..LKSAA.ATTGSSPKASSSAG..GDLSLIGSVSA......GSSSSSSSKERGADKDH
 1378- 1674 (411.20/76.75)	RAEKKALQ..FSGSGSSSSLSVSSGVGGVGA.GGRSKNATMKQLKQLDLSISVDGG..GGGSPATI.DL.....TGSPTSSGGITTSLGLGTGSI......AAAN........MLQ.ALQA.AKHQRGTSKSISQQQQQQ..QQQQQQH...G..GGALSAV....IDKLKSAQSTDGEDGAVLV.LPEM....TITQQTQPSSMAT.....GTSVNIGSFGALSGPGAGSSAITLKDV.............TKAGLLSSSSTSSS...SSSASLtncaslgINSASQSPS...MTSASGKASE....YM.VKP..SSDGIKLTiQNKKGSKSSSSSSSSSKGGTGG.GSGSSKTGLKPGVSSgpISSKQ.QH................................................
 1722- 1965 (288.66/51.60)	..........FQKSNSFGSLSGSSG.GGSGS.GGVLKAS.....................................SKVSSPKSTSNPG.NSSSY......ASSK.............DKS.SGGRLGSSKSSSTLGLSA..T.........GttGGSTSLVnpisIMKMLGYPTNASADGFA......K....TLDTKFQIPKLSA.....RTA......NAQSGNDGANEERTTKE.........................RGG...SSTVAG.......TKEASAAAS....RKQKQQQS..SSVG.......GGGGAG.....GSGTGAGTMRP......FAPSPSGSSNDG................TNASTPTNTNSARllSDLLGAGAVGGlktagkGTSAGTGGIEGNVSPLH
 1966- 2223 (275.03/48.80)	PLLPNIVQkmFGNESSGSSVPAAAAAASTAA.GAGS....MMSHK....SNSSDGSmfPGGSAAA..GLlanmrSGSAPSTPTTTTAAAAAAPSVlppypsPVANdsggvandLLS.AL.....MRPPSRPSITLSNHSH..IAQDGAV...D..GAGLASM.......LMMAGS.GGTAAAGLVgLDGA....TNTQQL....MA................AL............KSV.............AAAG....STVGNA...AERNHL................tnhHNHLQSNHHHTN..HHvTSP....ASVSVH.IVK....SPAPSPLPFASPHGGGGAGSAGGPGGIDDDM..LDEAL.IGIGS.............................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     119.64|      34|     290|     332|     368|       2
---------------------------------------------------------------------------
  332-  368 (56.32/27.23)	PGaGAGSTGGGGTGTG.STPTYAaiEKHNSTSLPATFV
  625-  659 (63.32/23.70)	PG.GPDGGAGGGSGLGsSTPDDS..NGFPSLSLGPPSV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33630 with Med1 domain of Kingdom Metazoa
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