<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33619

Description Uncharacterized protein
SequenceMFDTSSNSSNTIMQLVYWRSFARRCLVKPGGERDDRDDRELCVGDGGTGGGDRRANLIGPLVRDRASGAPFAPSPAREVVDRSSSSSSSSSDTPLERRSTRNDRAAENDDAQKKQPKHTQEQNAQNAPAAPPKMMISQVPSAGPRGLSGLRASSPSPTGYGARRHTRGSEEMHSSEMPCNCNREIRSSWKRSSSGSGFGIRTCRMFRSEEADRSGGGENGKTLNQRSSCQTSHGSRMMVVLLLLLLLITSSVGTNSDSFSPKARARRSVIPDRHTVKLYSIVPICEREKEKQTSVVPYAPLATATAAAAAAMRATIELVINMSGANPPRSVTPNAQQDYDVTRMREEDFERLAVYIVPDMPCEKGVPGRAEKTLPRSLTLKPSLVLSTPTSTTEGVWSTGVIPRGTRFGPFEGVRTPSHPSDKQLWRYFWRIFKDSDFFYLDGSDTTQANWMRYVASAYSFSVMNLVACQHQEHIYFYTIRDIMPNEELMVWYCRDFAKRLGYDIDPERATYSICREEVVKKTYKQPVPAEVAYNHVKHVMGLYLPTIRSTPTPSPSPPPVNSVPTPTSVLVPSKHLQQQQQQQQQQQQQHHHHQQQQQQMHHHIIINIIHSITSICIIRRCAALSEQQQQQQQQQQQQQQQLCRDRSPIRIMIREQSPLRTTGPADVKEIDADSPISQKETVHYEHQLTPNDGSVRSDEGYHSNGYHEDGFTPPEDSSDSESEHNYVLDCSKKAIEPKETSVPHKPHVVVVGASSVGGTTIGTIGPGSEIVDKNEYRKVKMKMPLKYEFKNNKNFKVEKELEMERQRERERELDELPSERDTVTTSPSTTTATAPAPGVTPTATTIREVTPATSTVIVLETKPDPTVVPLTKTYYEAEPSTSPPSTFIRYTPPSSSILETILTGNGGVRSIDRPADDPHRNRQPNATPPPTSPTEMAYSYKKSQRYGTACSPDSSSQNPQATDPQPVDALPSRSHALLQVAKDEDDMDLEEEDMDEEMERHHRHHHGVVHHHQHPHHHHQLVHSQQQQHQQQQQQQQQQHPHHLHHLERLHERDEVPRSPSPLYSSASSEHHHPHHPHHHHHHHHHQHHHYLQAHHPQPGGGGGGYEPPVQGYGLYPASSVINSASSSTYNSNGTATTTSSSSPSGASGGGSSPGAPSIATTPSSSSASSPPQSLAAAASSSSSSARSVSGSPARGRSPPGTPFAQQLQSKGQLPLGHPLMQPLTPLTHLSPGRGSPPSSLSPDGGSYSRSGSPMSPGSPNSRGYRSLPYPLRKRDGKMHYECNVCSKTFGQLSNLKVHLRTHSGERPFKCNVCTKSFTQLAHLQKHHLVHTGEKPHQCDICKKRFSSTSNLKTHLRLHSGQKPYACDLCPQKFTQFVHLKLHKRLHTNDRPYVCAGCDKKYISASGLRTHWKTTSCKPNNLEEELAMAAAATSECLDKDGQPDGDGGREFYEMHLSSSQQQQQQQDASRSPGPQHGRHPSPSSHHHHHHHPHLHPAPGSLTPLHTPEQVIHKVSAGKVQVQHPPTSSSNSNSSSAATNGTPSSNSNNNNNSNSTNHNLPAQHHLHYAGHLVSNGGAPGHHYHHPPPQQQQQHHHHYQQPSPQPQPGATAGAAAAAAAASTTTSSSASSGATNPGNTPETSRPSVIESSQPMVIECT
Length1658
PositionTail
OrganismAnopheles darlingi (Mosquito)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.05
Grand average of hydropathy-0.893
Instability index68.91
Isoelectric point8.59
Molecular weight182566.85
Publications
PubMed=20920257
PubMed=23761445

Function

Annotated function 
GO - Cellular Component
GO - Biological Function
DNA-binding transcription repressor activity, RNA polymerase II-specific	GO:0001227	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33619
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     150.17|      17|      40|     585|     601|       1
---------------------------------------------------------------------------
  585-  600 (30.76/ 9.84)	.........................QQQQQQHHHHQ....QQQQQ
 1010- 1030 (31.23/10.12)	V........................HHHQHPHHHHQlvhsQQQQH
 1031- 1047 (31.64/10.36)	Q........................QQQQQQQQQHP....HHLHH
 1048- 1088 (25.63/ 6.84)	LerlherdevprspsplyssassehHHPHHPHHHHH....HHHHQ
 1478- 1494 (30.92/ 9.94)	G........................RHPSPSSHHHH....HHHPH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     252.34|      26|      26|    1284|    1309|       2
---------------------------------------------------------------------------
 1259- 1279 (23.62/ 7.98)	GSPNSR..GYRS.LPYPLRKRDGK..
 1284- 1309 (51.31/26.76)	CNVCSKTFGQLSNLKVHLRTHSGERP
 1312- 1337 (44.81/22.35)	CNVCTKSFTQLAHLQKHHLVHTGEKP
 1340- 1365 (47.46/24.15)	CDICKKRFSSTSNLKTHLRLHSGQKP
 1368- 1393 (44.12/21.88)	CDLCPQKFTQFVHLKLHKRLHTNDRP
 1396- 1420 (41.02/19.78)	CAGCDKKYISASGLRTHWKTTS.CKP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     290.81|      49|      51|    1101|    1149|       3
---------------------------------------------------------------------------
 1111- 1159 (79.14/24.14)	VQGYGLY......P.ASSVINS.ASSSTYNSNGTATTTSSSSP.SGASGGGSSP...GA..PS
 1160- 1201 (64.30/18.35)	IATT.........P..SS..SS.ASSPP.QSLAAAASSSSSSA.RSVSGSPARG...RS..PP
 1209- 1246 (46.83/11.53)	LQSKGQL......PlGHPLMQP.LTPLTHLSPGRGSPPSSLSP.DG.................
 1554- 1587 (46.64/11.46)	NSTNHNL......P.AQHHLHY.AGHL...................VSNGGAPGhhyHH..PP
 1588- 1645 (53.90/14.29)	PQQQQQHhhhyqqP..SPQPQPgATAGAAAAAAAASTTTSSSAsSGATNPGNTP...ETsrPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.81|      10|      50|     574|     584|       4
---------------------------------------------------------------------------
  574-  583 (20.79/ 6.43)	SKHLQQQQQQ
 1458- 1467 (21.01/ 6.62)	SSSQQQQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     126.04|      25|      25|     828|     852|       5
---------------------------------------------------------------------------
  828-  852 (43.02/20.98)	PST.TT....ATAPAPGVTPTATT....IREVTP
  854-  880 (26.28/ 9.48)	..T.STvivlETKPDPTVVPLTKT....YYEAEP
  885-  914 (25.77/ 9.13)	PSTfIR....YTPPSSSILETILTgnggVRSIDR
  915-  936 (30.98/12.71)	PAD.DP....HRNRQPNATPPPTS....PTE...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.43|      11|      16|    1526|    1536|       6
---------------------------------------------------------------------------
 1526- 1536 (20.06/ 7.93)	PTSSSNSNSSS
 1543- 1553 (21.36/ 8.88)	PSSNSNNNNNS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.75|      14|      16|     104|     117|       8
---------------------------------------------------------------------------
  104-  117 (22.70/12.52)	RAAENDDAQKKQPK
  120-  133 (24.05/13.77)	QEQNAQNAPAAPPK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     118.47|      34|      37|     137|     171|      10
---------------------------------------------------------------------------
  137-  171 (57.72/37.39)	SQVPSAGPRGLSGLRASSPSPTGYGAR..RHTRgSEE
  175-  210 (60.76/34.82)	SEMPCNCNREIRSSWKRSSSGSGFGIRtcRMFR.SEE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.53|      16|      25|     374|     389|      11
---------------------------------------------------------------------------
  374-  389 (26.90/14.31)	LPRSLTLKPSLVLSTP
  402-  417 (30.62/17.37)	IPRGTRFGPFEGVRTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.35|      19|     402|     546|     571|      12
---------------------------------------------------------------------------
  527-  546 (30.87/23.24)	PVPAEVAYNHVKHVMGLYlP
  554-  573 (31.48/ 9.35)	PSPSPPPVNSVPTPTSVLvP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.87|      35|      37|     261|     297|      15
---------------------------------------------------------------------------
  261-  297 (56.96/45.09)	PKARAR.......................RSVIPDRHtvKLYSIVPICEREKEK.QTSVVP
  300-  358 (43.91/27.80)	PLATATaaaaaamratielvinmsganppRSVTPNAQ..QDYDVTRMREEDFERlAVYIVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.50|      18|      20|     715|     732|      16
---------------------------------------------------------------------------
  715-  732 (32.15/19.12)	PEDSSDSESEHNYVLDCS
  738-  755 (31.36/18.43)	PKETSVPHKPHVVVVGAS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33619 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EQQQQQQQQQQQQQQQLCRDRSPIRIMIREQSPLRTTGPADVKEIDADSPISQKETVHYEHQLTPNDGSVRSDEGYHSNGYHEDGFTPPEDSSDSESEHNYVLDCSKKAIEPKETSVPHKPHVVVVGASSVGGTTIGTIGPGSEIVDKNEYR
2) IRTCRMFRSEEADRSGGGENGKTLNQRSSCQ
3) KNFKVEKELEMERQRERERELDELPSERDTVTTSPSTTTATAPAPGVTPTATTIREVTPATSTVIVLETKPDPTVVPLTKTYYEAEPSTSPPSTFIRYTPPSSSILETILTGNGGVRSIDRPADDPHRNRQPNATPPPTSPTEMAYSYKKSQRYGTACSPDSSSQNPQATDPQPVDALPSRSHALLQVAKDEDDMDLEEEDMDEEMERHHRHHHGVVHHHQHPHHHHQLVHSQQQQHQQQQQQQQQQHPHHLHHLERLHERDEVPRSPSPLYSSASSEHHHPHHPHHHHHHHHHQHHHYLQAHHPQPGGGGGGYEPPVQGYGLYPASSVINSASSSTYNSNGTATTTSSSSPSGASGGGSSPGAPSIATTPSSSSASSPPQSLAAAASSSSSSARSVSGSPARGRSPPGTPFAQQLQSKGQLPLGHPLMQPLTPLTHLSPGRGSPPSSLSPDGGSYSRSGSPMSPGSPNSRGYRSLPYP
4) MAAAATSECLDKDGQPDGDGGREFYEMHLSSSQQQQQQQDASRSPGPQHGRHPSPSSHHHHHHHPHLHPAPGSLTPLHTPEQVIHKVSAGKVQVQHPPTSSSNSNSSSAATNGTPSSNSNNNNNSNSTNHNLPAQHHLHYAGHLVSNGGAPGHHYHHPPPQQQQQHHHHYQQPSPQPQPGATAGAAAAAAAASTTTSSSASSGATNPGNTPETSRPSVIESSQPMVIECT
5) TIRSTPTPSPSPPPVNSVPTPTSVLVPSKHLQQQQQQQQQQQQQHHHHQQQQQQMHHH
6) VKPGGERDDRDDRELCVGDGGTGGGDRRANLIGPLVRDRASGAPFAPSPAREVVDRSSSSSSSSSDTPLERRSTRNDRAAENDDAQKKQPKHTQEQNAQNAPAAPPKMMISQVPSAGPRGLSGLRASSPSPTGYGARRHTRGSEEMHSSEMPCNCNREIR
627
200
794
1429
547
27
778
230
1272
1658
604
186










Molecular Recognition Features






MoRF SequenceStartStop




1) AAAAAST
2) IMQLVYWRSFARR
1616
12
1622
24