<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33618

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMLLYDTALNIFRDHNFKSCTLCVCNAGAKCVGNIRGGDSGLYHALPGTNWMDSVVAANSGSNGETADGAAAAGGSAVANRNTKAPGGGMLAHLGLTGGPTNSGSGSSSSNGTAAVTISADSLQNGYLDEDPIDCQCGFSAVVNRRMAHRAGLFFEDEMEITGMAEDPAIHKKSSLFEFLNGTAKAIKPSADGSSTGGGSSGGNGGTGATTTTTVATATNSCESLPLTLKVMDLLREQCSMVQSSSNSIHRAVSRYRGPLFGRGADAATVHLLEYVDANDVISLALEQGRLQAINENKQLDQHQLDQQQQQPVTGGSNSNSSNGSGSSVGNALALAKGGGVVPRGTMNVHKWPFLRAGGPKSNQDIVRMMKSMQPLLQDAFHKKCTTRLWDAPYTIQGPLTWRQFHRLAGRGTGQCEPQPIPSLIVGYEKDWLSLAPYALHYWDKLLLEPYSYPRDVAYVAIVPDNDYVVSKVRTYFKELSTTYEMCKLGRHTPIKGWDGLLRVGAQRVLKETSNSNLDEWFTNMGMTTADMQRAGGKNGTAAGSSGRAAAGTSGATPSSSTTSSGLNELLRLYAQTCQQQLAPYLSKVPSDKSLLDPPESHHTGSSSSASSGSGSGGGGAGSGSAGAGGSSSSLGSGSAGAGGSAMGMNRDGPGQSPMPPPPPSTPDPSQPGDKAPNTPKFDHDADNRDQLNASSSSPADAMRIDDDGKDPPHIVLYIVEPFTCGNDSPDVERLACLSLLRCYSNILNAVPESIRSNISVQIVSLESILELGRARNRLRLSDHMRCLALSVFSQSRKYLAHSNTVKSLTGFGTAANAEQFIRGKDDKNRVPYRLYTPPYVLAKSSEKSENTESFGKPSIKQQCSIMYCSYCLSEDQSWLLAVATDDRGEFLETVTINIDIPNRARRKRASARRYGLQKLMDFILGLISQTVQPWRLVVGRIGRIGHGELKGWSWLLSKPNLQRASKHLKDICEQCSLMHPISVPSILSACLVTLEPDSDLRVMSDQFTPDERFSQRSMQSALSTPQDATCTHILVFPTSAKAQSAQVSFSAIGELDINEDLNNLIMDGDDDDDGMLGASDLLGFWDDLPMQPQMPSRPGSPSQFEGNQQSPGERGSNGAGSRDGYGSQDSEEVGVVLQQPLAIGYLVSTAPTGRMPAWFWSSCPHLENVCPVFLRTALHLHSPTILQNTDDLLQQNQSSTEHPLDSNITADVLRYVLEGYNLLSWLAMDSNTHDRLSCLPIHVQVLMQLYHMTAALA
Length1257
PositionMiddle
OrganismAnopheles darlingi (Mosquito)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.06
Grand average of hydropathy-0.366
Instability index44.37
Isoelectric point5.94
Molecular weight134540.17
Publications
PubMed=20920257
PubMed=23761445

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33618
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     287.08|      59|      62|      36|      97|       1
---------------------------------------------------------------------------
   36-   89 (74.65/40.22)	.......................GGDSGlyH...............ALPGTNWMDSVVA..aNSGSNGETADGAAA.....................AGGSAVA.NRNTKAPGGGM
   90-  152 (49.33/18.77)	L..AHLGLTG.................................................gptNSGSGSSSSNGTAAvtisadslqngyldedpidcqCGFSAVV.NRRM.AHRAGL
  153-  213 (58.58/23.71)	FfeDEMEITG.....................maedpaihkksslfeFLNGTAKAIKP............SADGSST.....................GGGSSGG.NGGTGATTTTT
  311-  340 (39.32/13.00)	........................................................PVT....GGSNSNSSNGS.......................G..SSVG.NALALAKGGGV
  521-  565 (34.03/10.60)	F..TNMGMTTadmqraggkngtaAGSSG..R...............AAAGTSGA.........TPSSSTTSSG...........................................
  621-  650 (31.17/ 8.64)	...............................................GSGSAGA.........GGSSSSLGSGSAG.....................AGGSAMGmNR.........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.72|      23|     496|     679|     739|       2
---------------------------------------------------------------------------
  654-  677 (42.30/52.58)	GQSPmPPPPPSTPDPSQPGDKAPN
  708-  730 (44.43/21.21)	GKDP.PHIVLYIVEPFTCGNDSPD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     118.65|      35|     501|     566|     619|       3
---------------------------------------------------------------------------
  580-  619 (57.02/42.26)	QLAPYLSKVPsdkslLDPPESHHTGSSSS......ASSGSGSGGGG
 1080- 1120 (61.63/19.37)	DLLGFWDDLP.....MQPQMPSRPGSPSQfegnqqSPGERGSNGAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.41|      17|      19|     771|     787|       8
---------------------------------------------------------------------------
  771-  787 (29.67/18.86)	LGRARNRLRLSDHMRCL
  792-  808 (27.74/17.17)	FSQSRKYLAHSNTVKSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.31|      20|     452|     467|     510|      10
---------------------------------------------------------------------------
  491-  510 (37.62/61.33)	HTPIKGWDGLL.RVGAQRVLK
  946-  966 (34.69/ 9.45)	HGELKGWSWLLsKPNLQRASK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33618 with Med13 domain of Kingdom Metazoa
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