<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33613

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMAEDNSWKTTNFRQSVVNKINEAIQQTGMTSSKNGIEMENHVFHKARNKDEYLGFVARLILHVREMNSKHKNQQNAAAAAAQQEGGNASQQGAGGGGGGGMPDPINALQTLASQGTRPQMMGQMGPGGPMGGQMGGGNANPNMLHTPRLQMAMGGMAGMQGGNRVGMGPGPNQMGGMMPNQMQGPGPGAGMGGMAGQMGVIGPGGMSGGKIVGMGGQQQQQQQQMAQLSAMQVNQMQAAQQQQQQQGGMPQQQGNMGQGPGVQQMGVVPGGPNQMNPMVMGQIQAQLQNQNAMGGQQMGAVGIGGGNPMGPIGGNTGMNPQAMGMASNQVIRQQMVQQGVNPNQVQMGLGPAQMGQLGAGVQGVGPGGPGPNIGQVQQQQVVVQQQQQQQQVQQQQHQQHQQLQQHLQHPQQQQQQQQQQLQQQHQPQLQQQMQNQQHQQHQQQLQQQQQHQMQQQQQQQQQQQQQQQQQHHQQQHQQQQIPQQHPQLQQHGQQHPQMQHAQHPQLQQQHQQQQQQQVLLGAMGQNVSGPVGPIGGPMGGPIGGPGGTGVPLQVQQAQAMQQQQQQQQGGGMGPNVGVGGPNQMNPVAMGPGPGGQMVGAQGNFVGMGGGNPMVRKPQDMMPGGNVYPGGGAAVRSVTPNNFLRQSPSPSVPSPVGPGAHGPQSHPGQMIPSPAIPSPNPMHGSVPQRSIGQSPGGSLNTPGQPGGAVPSPLNPQDEQLYREKYRSLTKYIEPLKRMIAKMENDDIDKIAKMKRLLEILCNPSVRIPLETLHKCEAALTSQLGSIRETPTNNPLVEAVSSSLQNATGNHTLQRTFRPCLEALFGPDIKNLPPPTKQPRLGAASSGGQDDSNASGGTGSGPGSSVTGGTTSTSGTTSSASNNAASVGGSAGSASNNQEIPHILQGEIARLDQKFKVSLDPCAITGSKTIKLICWLDDKSLPCVPPVAVTIPDDYPFTAPSCSLIEQEYNATPFLILVQRSFIARICKLPALFTLSHLLDTWEMSVRQACSPHPTLVAPTTTSVLLGM
Length1026
PositionTail
OrganismAnopheles darlingi (Mosquito)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.02
Grand average of hydropathy-0.705
Instability index59.51
Isoelectric point9.13
Molecular weight108421.82
Publications
PubMed=20920257
PubMed=23761445

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364148
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP33613
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     368.28|      44|      44|     389|     432|       1
---------------------------------------------------------------------------
  103-  160 (51.91/ 6.02)	DPinALQtlasQ........GTR.PQMMGQMGPGGPMGGQMGGGnanpnmlhtprLQMA.....MGGM.AGMQ
  259-  310 (65.21/10.18)	GP..GVQ....QmgvvpggpNQMNPMVMGQIQAQLQNQNAMGGQ...........QMGAV....GIGGGNPMG
  368-  408 (70.92/11.96)	GP..GPN....I........GQVQQQ...QVVVQQQQQQQQVQQ...........QQHQQ....HQQLQQHLQ
  409-  445 (68.20/11.11)	HP..QQQ....Q........QQQQQQLQQQHQPQLQQQM...QN...........QQHQQ....H...QQQL.
  446-  475 (54.45/ 6.82)	...........Q........QQQQHQMQQQQQQQ.QQQQQQ.QQ...........QQH......HQQ.....Q
  503-  543 (57.59/ 7.80)	HP..QLQ....Q........QHQQ...QQQQQVLLGAMGQNVSG...........P....vgpiGGPMGGPIG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.98|      20|      21|     207|     227|       4
---------------------------------------------------------------------------
  209-  230 (27.38/ 7.92)	GKIvGMGGQQQQQQQQMAQlSA
  574-  593 (33.61/ 8.39)	PNV.GVGGPNQMNPVAMGP.GP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      92.16|      19|      26|     667|     686|       6
---------------------------------------------------------------------------
  185-  200 (33.69/ 8.27)	PGPGAGMGGMA....GQM....GV
  608-  626 (28.41/ 8.50)	GGGNPMVRK.P....QDMmPGGNV
  676-  698 (30.06/ 6.28)	PSPNPMHGSVPqrsiGQS.PGGSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.14|      15|      19|     858|     872|       7
---------------------------------------------------------------------------
  858-  872 (26.91/12.99)	SGPGSSVTGGTTSTS
  879-  893 (25.23/11.69)	SNNAASVGGSAGSAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     107.39|      34|     165|     789|     823|      11
---------------------------------------------------------------------------
  789-  823 (60.75/38.51)	PTNNPLVeAVSSSL....QNATGNHTL.QRTF..RPC.LEALF
  950-  991 (46.64/24.72)	PDDYPFT.APSCSLieqeYNATPFLILvQRSFiaRICkLPALF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33613 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ALTSQLGSIRETPTNNPLVEAVSSSLQNATGNHT
2) GGQQMGAVGIGGGNPMGPIGGNTGMNPQAMGMASNQVIRQQMVQQ
3) GMSGGKIVGMGGQQQQQQQQMAQLSAMQVNQMQAAQQQQQQQGGMPQQQGNMGQGPGVQQMGVVPGGPNQMNPMVMGQIQAQLQNQN
4) MAEDNSWKTTNFRQSVVNKINEAIQQTGMTSSKNGIEMENHVFH
5) PDIKNLPPPTKQPRLGAASSGGQDDSNASGGTGSGPGSSVTGGTTSTSGTTSSASNNAASVGGSAG
6) QHQPQLQQQMQNQQHQQHQQQLQQQQQHQMQ
7) QQQQQQQQQQQQQQQHHQQQHQQQQIPQQHPQLQQHGQQHPQMQHAQHPQLQQQHQQQQQQQVLLGAMGQNVSGPVGPIGGPMGGPIGGPGGTGVPLQVQQAQAMQQQQQQQQGGGMGPNVGVGGPNQMNPVAMGPGPGGQMVGAQGNFVGMGGGNPMVRKPQDMMPGGNVYPGGGAAVRSVTPNNFLRQSPSPSVPSPVGPGAHGPQSHPGQMIPSPAIPSPNPMHGSVPQRSIGQSPGGSLNTPGQPGGAVPSPLNPQDEQLYREKYR
8) VNPNQVQMGLGPAQMGQLGAGVQGVGPGGPGPNIGQVQQ
9) VREMNSKHKNQQNAAAAAAQQEGGNASQQGAGGGGGGGMPDPINALQTLASQGTRPQMMGQMGPGGPMGGQMGGGNANPNMLHTPRLQMAMGGMAGMQGGNRVGMGPGPNQMGGMMPNQMQGPGPGAGMGGMAGQMGVIG
777
294
205
1
825
424
456
340
63
810
338
291
44
890
454
725
378
202










Molecular Recognition Features






MoRF SequenceStartStop




NANANA