<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33608

Description Mediator complex subunit rgr-1
SequenceMAPQPLEQGGAVTSFIPTGQEMAQRQNLIPLRQLIDFIIQRTYHELTVLAELLPRKTDMDRKIEIYNFSASTRQLFIRLLALVKWANSASKVDKSAKIMGFLDKQSMLFIDTADMLSRVARETLVHARLPNFHIPAAVEILTTGTYSRLPSIIRERIVPPDPITPAEKRQTLQRLNQVIQHRLVTGNLLPQLRKFRIENGRVTFKVDHEFEVSLTVMGDAPTVPWRLLDIDFLVEDKETGDGKALVHPLQVNYIHQLIQGRIVDCTDALAEVYTCLHYFCQSLQLEVLYTQTLRLIRDRLDDHIHVDEYIVGSKLTVSYWRELTNKDPKSELGYRLTIQTDPNDCAKQLAILHVPSIGNKEADIADRAVRSDLLSMERLLVHTVYVRSLARLNDVKTELQLFLKDVEYNIHGTPAMLTVPVLNPCLRAEHIYITVDTHTGMLRCHVPKHLDCPIMPDMQHALNNDWSKLQHLISELRYWITQRRCEKTLQHLPASTQDRLPLLYPPNHPISRMGPHKVFIQLYRHANVILIVELKEKKSCPNEMTYTFYVALVKPSSVEEGQTGGPDAPSNAGPSAGGAPGSAEATAGMPKMYLRVLSLIEFDTFVATHGPGTYIDEPLAGCNKRKQLASELTSGVVGPPVKQQKTIYPAYFIPELAHVVAMCDEKLPFVALAKEFSSRRIPHGGLQVEANATSLVLKLLTLPQPKPPQIVPTNPQQQQQQQQQQHQQQQQQQQQQSHPQQSATGPDGKATNEPKTVHVPPIDKQVWNALLKRLLSVSVRAQVNKSNQTRPWTMELVFYGSPLPSQHHKEQGMRRAVYLQYEMLPVDSVGKVVDQLLNDWSKIVYLYTLVHEFQEQLANEKYNLASMVTIKSYSYTNLLLAYGPNKDVSVNICWDTEAKEFKLVFTGGNSAINAHSMMRDQLQAHLNHNYNLAQIVHILHETYQPLSSIAKLPIIPHLAILQSPKIPVLSFCIIPQSPTLLRISFQGVYCLEVRFRGGGLCTVRDGAYSRFDRTHVVEEFTPTQGLKGFLSKYVDESVFRRRSQSEDDNPPSPVTMEDPSHMVGSVGGGAGGGGGGGGGGANNLFGGGAGSGMRGPQSPRDPGLRFAAPVTPPTGSNPHTPASPHPQVGGSGSAGGPGGGAGAGGQGNHMNNFNMTSPPASHMPHPSPSGGLMPSSPLNAQPSPMAAHSPGPSNLAYMQSHTDGSPFAALSPAASNWPGSPGMPRPSPRPGQSPEHKVQTPHHYTSRVIPARSWAGAIPTLLTYEALDTLCRATSHPQKEIPGPELSPLERFLGSVFMRRQLQRIIHQEDSLMAIQSNEPGVVVFKADCLQYQVFLNPNHMQSLHLKANQLQMGGNTMMDGKPVYQWANEDLQVLEQFFDQRVAAPPYRPSVMTSFTRMLNLPAKVLMDFIQIMRLDLMPELGQGNKWNVQFVLRMPPSATPIVPVGTTTILSHRQKILFFIQITRVPYLPNMEWKDAVTMLLPMVYDMNMNHTTLAERREPMPPQLTSAVSAHLRRFSECSVLQQGECSLFPAVRDLLLTLTLPNEPPAPGQMPLQMGGVMQQGGPGGPGGPGGPMGGQNTGPTGQVVVGPVGSSPNPMIHSPMQQQQMVGGGGGGGQPQGNYGGMVGGGPGGPQSGGGPN
Length1642
PositionTail
OrganismAnopheles darlingi (Mosquito)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.07
Grand average of hydropathy-0.312
Instability index52.97
Isoelectric point8.52
Molecular weight180895.43
Publications
PubMed=20920257
PubMed=23761445

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33608
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     465.81|      65|      66|    1049|    1113|       1
---------------------------------------------------------------------------
 1012- 1057 (58.96/22.40)	D..RTHVVEEFT..PTQGLKGFLSKYV..DESVFR.......RRSQSE............DD..........NPPSPVTME
 1058- 1122 (122.88/56.16)	D..PSHMVGSVG..GGAGGGGGGGGGG..ANNLFGGGAGSGMRGPQSPRDPGLRFAAPVTPP..........TGSNPHTPA
 1123- 1188 (74.75/30.74)	S..PHPQVGGSGsaGGPGGGAGAGGQGnhMNN.FN......MTSP.....PASHMPHP.SPSgglmpssplnAQPSPMAAH
 1189- 1241 (67.24/26.77)	SpgPSNLAYMQS..HTDGSPFAALSPA..ASNWPG...SPGMPRP.SPR.PGQSPEHKVQTP...................
 1555- 1602 (81.12/34.10)	...PLQM.GGV.....MQQGGPGGPGG..P....GGPMGGQNTGP.....TGQVVVGPV..G..........SSPNPM.IH
 1603- 1641 (60.87/23.41)	S..PMQQQQMVG..GG..GGGGQPQGN..YGGMVGGGPG....GPQSGGGP..............................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     354.47|     113|     311|     126|     248|       2
---------------------------------------------------------------------------
  126-  248 (178.63/138.87)	HARLPNFHIPAAVE..IL......TTGTYSRLPSIIRE.RIVppdpITPAEKRQTLQRLNQVIQHRLvtgNLL..PQLRKFRIENGRVTFKVDHEFEVSLTV.MGDAPTVPWRLLDIDFL.......VEDKETGDGKAlvhP
  438-  569 (175.85/111.75)	HTGMLRCHVPKHLDcpIMpdmqhaLNNDWSKLQHLISElRYW....ITQRRCEKTLQHLPASTQDRL...PLLypPNHPISRMGPHKVFIQLYRHANVILIVeLKEKKSCPNEMTYTFYValvkpssVEEGQTGGPDA...P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     136.53|      41|      48|    1410|    1456|       3
---------------------------------------------------------------------------
 1410- 1454 (69.95/55.19)	FIQIMRLDLMPELgqgnKWN......VQFVLRMPPSAT.......PIVPVGTTTILSH
 1461- 1514 (66.58/36.35)	FIQITRVPYLPNM....EWKdavtmlLPMVYDMNMNHTtlaerrePMPPQLTSAVSAH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.85|      13|      18|    1325|    1342|       4
---------------------------------------------------------------------------
 1325- 1341 (20.72/27.99)	FKADCLQyqvfLNPNHM
 1346- 1358 (24.13/10.98)	LKANQLQ....MGGNTM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     112.92|      36|     525|     737|     775|       5
---------------------------------------------------------------------------
  737-  756 (15.11/11.08)	...................S...HPQQSATGPDgkaTNEPKT
  757-  775 (20.70/ 6.36)	VHVPPIDKQVWNALLKRLL.......................
 1262- 1285 (33.93/16.56)	LTYEALDT......LCRATS...HPQKEIPGPE.........
 1286- 1322 (43.18/24.61)	..LSPLERFLGSVFMRRQLQriiHQEDSLMAIQ...SNEPGV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.06|      22|     525|     853|     879|       6
---------------------------------------------------------------------------
  853-  875 (34.76/28.87)	FQEQLaNEKYNLASMVTIKSYSY
  922-  943 (39.30/18.67)	LQAHL.NHNYNLAQIVHILHETY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.27|      10|     841|     699|     708|      13
---------------------------------------------------------------------------
  699-  708 (20.53/ 9.33)	LLTLPQPKPP
 1539- 1548 (18.74/ 7.82)	LLTLTLPNEP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33608 with Med14 domain of Kingdom Metazoa
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