<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33605

Description Uncharacterized protein
SequenceMMSSEEDSDSFGLYVDKLLKKHDPNAATNSNSNSSCSSSGSVSSSKQQQQQQQQRSRQRVDAGEPRNSYSSIPNFSSRPSSFMSGGLYGAIFSQAQQQHFSGLFGPGGYGPAASKMLNELLGRQVKQAQDATDPDTLSMLSAIEAAAASINSSTSSSSSVGGGNGSSGTAAGNTSGLGAASAGTTGLLIESGVNGVSGGVGGATTTNHVVNPAKHGFESVTNLNNNNTNTNNNNNNNSNNGCNNNNVTSGSNGSSANGGNTGSAAVVTVATTTTTMAAVSSDVTQMISNRRSSSTSSTSSTSSTTSSSSTSSSSNTSLHSNASHLSNSSNGGGIGGIIGGAIGGAHTGNSADGGGGGVVGAAAGKLAAAVVDACSNGLGGVIDLDGDSTTPPTNSELAHHMLRNILQGKKDLMALDQELRAISGRSVEAAGDRLSPDNNNVIGSKNNNNNNTIFEVSSSKSSENSNSDVAIVNGGDLSDSSDNNHAATIAAAMAPSEVALGAKGKVIASQNAKSLGSDSTKCDELIGGGSSEQQQHQQANDRLAVNGVNPKQEKSDVIDELVASLPDEVDETMPSPSSGVSNDMIIAKQEMDIDDCCVEDKDRDDRTPSPGTGLVVGRAEPEALNMKRARVENIVSTMRASPASILAVQPPVNGCKKRKLYHPQQHDNSAAERYAAAAAAGLNLGLTLQNFMLSSSAAAAAAAAAATANTDPATTDDDEDLVETVATPHIHQKRVEKDVLKSQLRSMQEQLAEMQQKYVQLCSRMEQQSDTTQEVVDDSSTSDIMEDDRASAPDLSSPSKSSLLQTSLTAGSTPVKDTGKGQSTAAAAAAAAAAADASSMLQMMSKMMSAKLHSQLPSAHPALQAAGFNGTHPFLQHMQQAAAVAAALPHDSVSSQQQQQQQQQQQQQQQQQQQQQQQQQQQISNAAAMYQKLFMEQEARMVKGEQVERNQQAANQQLLQQQQQQQQQAQQQSQAIAQAQQQQQERQTQQSQQQTPQPPHPHPALLQDRSTSNSSSQGHQAQVTLPQPPAPTQNAIPPSQPQLQSPVPHPQQQQQQQHSPRQLQPAAQQPLLGVAQQPVLQPQPPSPPQSQLCTSSSLSSGPQQPLQQQQQQSQQPLQQPPVHHIGSTPLGPLPAIPKGSAIPSDLTNRLNMMRSTVGSVGPMSGTDLEGLADVLKTEITASLSNLVDSIVTRFVHQRRFLGKQSEAAAAAAEQLNKDLLMASQLLDRKSPRTKLGSAVDRAQTALYQASKGPQTMNPVAAAALYNSMNQALGGGAPTGTPTAVNPFCLPPPPEPREPNPEQYEALSLVVTPKKKRHKVTDTRITPRTVSRILAQDGIIPSSNPVQVDSQQQQQQQHHQQQSQQHQQHHQQQQQQQQQSAQATQQQQQQASQQLPIGGGAGSCPAGTMGSNINNNNNNSCNKNNNNNSSSNAQNNQQAAQQSLNQSQQHLTQQQQQQQSQSQQQQQQPPQAAQFNGQSGPGGSAKPGPTSPTNNECTSPRSSFHGAAAAAAAAAASMLPVSLPTSVAIPNPSLHESQVFSPYSPFFNPHGGPHGPQPSQFHHMKVSSSPPGINGMMDPRDSPPLPHPPTMLHPALLAAAHHGSSPDYGHIRASMDVNDRNSDCTSADISNESLTPVNSSTLTPMHLRKAKLMFFWVRYPSSAVLKMYFPDIKFNKNNTAQLVKWFSNFRIITINRPPSQHRARYLALIYLNAYAASQQNTTILPSPSRCHTDAYRSVGPFSWFRSAGPEGLEQQLMCGFILRRDVHTEFYYIQMEKYARQAVSEGMKNADDIHVSNDSEIYRVLNLHYNRNNHIEVPQNFRYVVEQTLREFFRAIQSGKDTEQSWKKSIYKIISRMDDPVPEYFKSPNFLEQLE
Length1874
PositionKinase
OrganismAnopheles darlingi (Mosquito)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.04
Grand average of hydropathy-0.696
Instability index64.08
Isoelectric point6.38
Molecular weight199444.88
Publications
PubMed=20920257
PubMed=23761445

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
DNA binding	GO:0003677	IEA:UniProtKB-KW

GO - Biological Process
regulation of transcription, DNA-templated	GO:0006355	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33605
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     390.78|      44|      44|     878|     921|       1
---------------------------------------------------------------------------
  878-  921 (86.62/25.18)	MQQA..AAVAAALPHD......S....VSSQQQQQQQQQQ....QQQQQQQQQQQQQQQQ
  923-  968 (48.39/10.96)	ISNA..AAMYQKLFME......QearmVKGEQVERNQQAA....NQQLLQQQQQQQQQ..
  995- 1042 (55.58/13.64)	TPQP..PHPHPALLQD......R....STSNSSSQGHQAQvtlpQPPAPTQNAIPPSQPQ
 1043- 1072 (46.96/10.43)	LQ........SPVPH..................PQQQQQQ....QHSPRQLQPAAQQPLL
 1075- 1120 (53.68/12.93)	AQQPvlQPQPPSPPQSqlctssS....LSSG......PQQ....PLQQQQQQSQQPLQQP
 1343- 1373 (47.48/10.63)	...............N......P....VQVDSQQQQQQQH....HQQQSQQHQQHHQQQQ
 1436- 1470 (52.07/12.33)	.QQA..A.......QQ......S....LNQSQQHLTQQQQ....QQQSQSQQQQQQPPQ.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     268.08|      43|      43|    1484|    1526|       2
---------------------------------------------------------------------------
 1231- 1276 (54.88/20.39)	PRtklGSA...VDRAQTALYQASKGPQTMN...PVAAAALYNSMNQALGG.GA
 1277- 1302 (38.93/12.26)	PT...G.......TP.TAVNPFCLPPP.......PEPREPNPEQ.........
 1480- 1522 (72.42/29.33)	PG...GSA...KPGPTSPTNNECTSPRSSF...HGAAAAAAAAAASMLPV.SL
 1523- 1568 (57.24/21.59)	PT...SVA...IPNP.SLHESQVFSPYSPFfnpHGGPHGPQPSQFHHMKVsSS
 1569- 1604 (44.61/15.15)	PP...GINgmmDPRDSPP....LPHPPTML...HPALLAAAHHGSS.......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     246.73|      39|      43|     309|     347|       3
---------------------------------------------------------------------------
  166-  205 (38.11/13.98)	....SSGTA.AGNTSGLGAA.....SA...GttgllieSGVNGVSGG.VGGATT
  214-  242 (33.00/11.12)	KHGFESVTNLNNNNTNTNNN.....NN...N.......NSNNGC..........
  243-  272 (35.77/12.67)	...NNNNVTSGSNGS....S.....AN...G.......GNTGS..AAVVTVATT
  309-  347 (63.84/28.41)	STSSSSNTSLHSNASHLSNS.....SN...G.......GGIGGIIGGAIGGAHT
  350-  389 (41.52/15.89)	SADGGGGGVVGAAAGKLAAAvvdacSN............GLGGVID..LDGDST
  423-  459 (34.49/11.95)	.....SGRSVEAAGDRLSPD.....NNnviG.......SKNNNNNNTIFEVSSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      30.66|      10|      16|     461|     471|       4
---------------------------------------------------------------------------
  461-  471 (12.65/11.98)	SSENsNSDVAI
  480-  489 (18.01/11.19)	SSDN.NHAATI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.73|      29|     147|     131|     159|       5
---------------------------------------------------------------------------
  131-  159 (45.29/21.33)	ATDPDTLSMLSAIEAAAASINSSTSSSSS
  278-  306 (48.44/23.35)	AVSSDVTQMISNRRSSSTSSTSSTSSTTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     161.34|      48|     147|     633|     680|       6
---------------------------------------------------------------------------
  575-  638 (47.52/23.65)	..SPS.......SgvsndmIIAKQEmDIDDCcvedKDRDDRTPSPGTGLVVGR.AEPEALnmkrarveNIVST....M
  639-  692 (73.74/41.38)	RASPA.......S......ILAVQP.PVNGC....KKRKLYHPQQHDNSAAERYAAAAAA......glNLGLTlqnfM
  795-  835 (40.09/18.63)	LSSPSkssllqtS......LTAGST.PV.........KD...TGKGQSTAAAAAAAAAAA..................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.77|      18|     390|     970|     994|       7
---------------------------------------------------------------------------
  970-  994 (25.33/18.67)	QQQSqaiAQAQQQQQerqtQQSQQQ
 1376- 1393 (35.44/11.77)	QQQS...AQATQQQQ....QQASQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.06|      26|      35|    1122|    1148|       8
---------------------------------------------------------------------------
 1122- 1148 (42.71/42.38)	VHHIGSTPLGPLPAIPKgSAIPSDLTN
 1160- 1185 (42.34/34.74)	VGPMSGTDLEGLADVLK.TEITASLSN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.71|      23|     463|      45|      67|       9
---------------------------------------------------------------------------
   45-   67 (41.13/19.20)	SKQQQQQQQQRSRQRVDAGEPRN
  530-  552 (40.59/18.85)	SSEQQQHQQANDRLAVNGVNPKQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.93|      24|     463|     721|     744|      10
---------------------------------------------------------------------------
  721-  744 (42.06/30.31)	LVETVATPHIHQKR...............VEKDVLK.SQL
 1186- 1225 (27.87/17.49)	LVDSIVTRFVHQRRflgkqseaaaaaaeqLNKDLLMaSQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     174.98|      51|      54|    1636|    1689|      11
---------------------------------------------------------------------------
 1636- 1689 (86.81/64.05)	VNSStltPMHLRKAKLMFFWVR.YPSSAVLKMYFPDIKFNKNNTAQLVKWFSNFR
 1693- 1744 (88.18/57.54)	INRP...PSQHRARYLALIYLNaYAASQQNTTILPSPSRCHTDAYRSVGPFSWFR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33605 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AAAAAATANTDPATTDDDEDLVETVATPHIHQKRVEKDVLKSQLRSM
2) GLYVDKLLKKHDPNAATNSNSNSSCSSSGSVSSSKQQQQQQQQRSRQRVDAGEPRNSYSSIPNFS
3) KMLNELLGRQVKQAQDATDPDTLSMLSAIE
4) NPVAAAALYNSMNQALGGGAPTGTPTAVNPFCLPPPPEPREPNPEQYEALSLVVTPKKKRHKVTDTRITPRTVSRILAQDGIIPSSNPVQVDSQQQQQQQHHQQQSQQHQQHHQQQQQQQQQSAQATQQQQQQASQQLPIGGGAGSCPAGTMGSNINNNNNNSCNKNNNNNSSSNAQNNQQAAQQSLNQSQQHLTQQQQQQQSQSQQQQQQPPQAAQFNGQSGPGGSAKPGPTSPTNNECTSPRSSFHGAAAAAAAAAASMLPVSLPTSVAIPNPSLHESQVFSPYSPFFNPHGGPHGPQPSQFHHMKVSSSPPGINGMMDPRDSPPLPHPPTMLHPAL
5) NSNSDVAIVNGGDLSDSSDNNHAATIAAAMA
6) QQKYVQLCSRMEQQSDTTQEVVDDSSTSDIMEDDRASAPDLSSPSKSSLLQTSLTAGSTPVKDTGKGQSTAAAAAAAAAAADASSMLQMMSKMMSAKLHSQLPSAHPALQAAGFNGTHPFLQHMQQAAAVAAALPHDSVSSQQQQQQQQQQQQQQQQQQQQQQQQQQQISNAAAMYQKLFMEQEARMVKGEQVERNQQAANQQLLQQQQQQQQQAQQQSQAIAQAQQQQQERQTQQSQQQTPQPPHPHPALLQDRSTSNSSSQGHQAQVTLPQPPAPTQNAIPPSQPQLQSPVPHPQQQQQQQHSPRQLQPAAQQPLLGVAQQPVLQPQPPSPPQSQLCTSSSLSSGPQQPLQQQQQQSQQPLQQPPVHHIGSTPLGPLPAIPKGSAIPSDLTNRLNMMRSTVGSVGPMSGTDLEGLA
7) RSVEAAGDRLSPDNNNVIGSKNNNNNNTIFEVSSSKSS
8) SDSTKCDELIGGGSSEQQQHQQANDRLAVNGVNPKQEKSDVIDELVASLPDEVDETMPSPSSGVSNDMI
9) VNGVSGGVGGATTTNHVVNPAKHGFESVTNLNNNNTNTNNNNNNNSNNGCNNNNVTSGSNGSSANGGNTGSAAVVTVATTTTTMAAVSSDVTQMISNRRSSSTSSTSSTSSTTSSSSTSSSSNTSLHSNASHLSNSSN
701
12
115
1257
464
755
425
517
193
747
76
144
1595
494
1172
462
585
330










Molecular Recognition Features






MoRF SequenceStartStop




1) KKRKLY
2) MMSSEEDSDSFGLYVDKLLKKHDPNA
656
1
661
26