<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33604

Description Thyroid hormone receptor-associated protein
SequenceMNMRPLKRPRLGPPDVYPQEAKQREDELTSVHVKHGFATEHKLSEEFGTARNCNVSASKVGAYFNAILAKKEELMTLPDSGRKKQQINPKDNFWPVTARNKTTLDMWFKDLAGTKPLSSLAKKAPSFNKKEEIFAMLCENQVTMQRAAWFIKLSSAYTVAVSEAKIKKRQMPDPATEWTGTMIKFLKDLIPKLHEHYHHGPLQEKPSSGMGSTGGVSLNNSGGASALGMSSASGGSNPTTIPPPLSSPAGSMHSPAGSNSAAGGAMHSQQQQQQQLQQPLSPQEEQRLAQKQWNYSTQLCKYMYEEGLLDKQEFLNWIIDLLEKMKSSPNADDGLLRIYLPLAMQYLHDFVQSERFCRRLSYAVSKKLAQLINQMADNHNVNLHASEPDSTGGSKVSPDVAEPKDGKNDKMSNGGIVTAKPNPYELIFTEYLHCSHHRDVVLQLSCILQTITLECPTALVWCGVGETRSSSVLSGSPLDHLPVAPSALPMPERYAGNSNEDVRRQLFEAEESIKIRSRHAESRWCIDKWQTAAGNASLKILATLDALDGHCFDRMDSNNSLDFLYQKIFPPFQIQPIKPTTDGGAISGNPASLVGVAAAGASANGIDGKDAATKQFEYNVEQDASIVKILCEWAVSWQRWGEHRAMVVAWLLDKRQNEVFTALENESYSNNNLNNSDDKDSVLSGSGLNGGQPVFQHILMNFLDHDAPVLEDNGGTQSKSQFTNLVHLFSELIRHDVFSHDAYMCCLISRGDLLTGAGGMLSLDNHGICNAGLGTGPISNKPATSSSPNNPSGMDDDVLQTDFKAKLEDLDDSNVDDDLDKLLQHIKEDQQNSMDAPDSPKDPEHASASVGTGLGKAESPSRHFLYTEHFPLCQDDPISQHDCNQRYILLYGVGKERDEKKHAVKKMSKEICKLFSKKFSIDVAEGGKVKKHARSEFNFEATSNKCQAMSYFDQHVVTWQCAVQVQEMLNSFAAGNSYYLPVQEHVAFLFDLMESAFNIYGLIDTCIQILRELPEVEMQLIAKGSMPLVRSYTTSLSLYVVGVLRRYHCCLLLSQEQTTAIFEGLCRIVKHVSNPSDCSSAERCILAYLYDLYSACSSLKSRPQQEPFHNAYPKIKQALYTPLQPTPSVHTYNPQFMIDIITNPRRGGKIESGWARQLNESASNRYSFVCNAVVAVTRDIDNDCLNDIAAMCAELTACCNSLSSEWLGVLIALCGSNRDAGYYVDVLTQVDVQNTNIHNALSVFTSILVARHCFSLENFVAHVALPSLVQACKGRGETTPEIEAGARLSCHLLLRLFKTIECPQPGLYSVSTSPNPITVGNAHNIKLSCDRHLLAAAHKNIGVAPVLAVLKGILVVGDATANKVSSIFGTGKRSGLNTPVHPGSTPKSMSGSGDISHILGTSDLSILGNADESMLDVSMIELEELSPTASSARLYPSRQQNSHLNQDNATSLSEFAQHVLRQICSQEWVLERCLQNAEELCQQGMLIDNLLTAKQAQRLLHMICYPEHESNLIAELDQKAIIVRILENLEQWSLRISWLDLQLMFKQTNCSSPELSNWLDMVARAAIDVFRVNEFYVSGPDAKQEKVKPSTWLVAPLVSKLPSAVQGRILKVSGQVLESTSMFSKHKDGNGGNNSSNNNSHSHGANSNSSVSSNGSTFASKQSSQLNHQPFLGLVLTCLKGQDEQKEGLLQSLYAQLSQFLQNRDQSLETVGGIEDPCGFEKMLDALQLRYSLVGGLFDAIMKNATSTTDWAILFAQLISQGVIDLSNNSELFTTTLDMLATLIHSTLVSDSQTERDENKKLYTNLMKKLRKELGDKNGPSIKYVRQLLPLAKQTCEVIACESAGSSTDAKGNKINIDSIEKKHGLRLADKQRVSVWDLLEGHKNPAPLSWAWFGAVKIERKPLAYEETHRLLKYHTHSLFKPSSYYYEPLPLPPEEVDPLPDKLKDEMKADTPSSDQSPAPSTSSKKGKTVRKRKPKATAASQAAQNQAQAQPVMPALAATNAPQQMQQMQQQQLQQQQQQQHTLQQQQQQQQQHLQQHQQQQQLHLQQQHLQQQQQMQQQLQQQQQLQQQQQQQQQQQNQLMMQQQQQQSNLGQQQNNMQQQLGAQQQVGMTPQQTLQQMQNNNMGGMQMGGSMNPMNQQHLQQQYGQPNAGQMVGQGNIGGMQPGMGGMGPGMNASLMQQQQQQQQQQQQQQQQQQQQQQQQPQQAQQQQSQQGPQQQPQQQQGNPNMGFVGNVNQMNQMAGQGAGGQQWGGYNPMQQQQQQQSQQQQAQQQSQPQPQSQQQQSQQQQQQQQQQAGPQQTGPQQGAQQGPQQGPQQASQQLQQQQMYYGQGMGQGPINRYDRPALNNPKQALSNMLRSKIPMNAGHPGFMQQQQQQQQQQQAQAQRNPQQQAFIRGPMRAGMPGNPVVGNPGAMGPMNPAMAGGGAGLGTAAGVGGSGGGAGGAGGNVAAGVMGGGQQGGMGAAGMMGVQQGGQGPPGAAGMMNQNSAGLMGSSGASIMGQSGGSMIQANMLNQQNPALVVGQGMGSGGGGSGGAGAGASGGGGGAGIGAGSGMVTGNAGMGGNAGGMGSNAGGMGGNVGGMGTSGGMVTSGGMVTGGMGNSGIGTATAMGGGQGAMGNSGMANNAGMGNPGMANPGMGMGNMQQQGGNMQGGMFQGQNVPYQNVNQNYPNYGNQGMGQQGGQGGMMGNFNPMAQQQRNTQAEFLAQQQRALAAGRGQYGQHAPNVTMGNMGVNQGAVPPYPRQGGKPGVGGNIPQTQQQFQQQQRLRLMMQQQQQQQQQSGMGQGGNAQGLIQNQGQGMNTQQTPNLVAQLQRQMPNQNNMMGQQYPHQPPQY
Length2837
PositionKinase
OrganismAnopheles darlingi (Mosquito)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.05
Grand average of hydropathy-0.592
Instability index53.16
Isoelectric point6.76
Molecular weight308436.09
Publications
PubMed=20920257
PubMed=23761445

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33604
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             9|     877.11|     101|     101|    2126|    2226|       1
---------------------------------------------------------------------------
 1982- 2051 (80.94/17.07)	.......................................................ASQ............AAQNQAQA.QP..VM.........................PALAATnapqQ......................MQQMQQ..Q....QlQQQQQQQhtlQQ..QQ...QQQQQHLQQHQQQQ.QL.HLQQQ
 2054- 2099 (91.38/20.20)	QQQQQ..........................................................................................................................................MQQQLQ..Q....Q.QQLQQQQ...QQ..QQ...QQQNQLMMQQQQQQSNL.GQQQN
 2126- 2221 (199.83/52.77)	........NMGGMQ.MG.....GSM...NPMN.QQHL.........QQQYGQPN.AGQ.....M.....VGQGNIGGM.QP..GMG.G......M...G...........PGMNAS....L......................MQQQQQ..Q....Q.QQQQQQQ...QQ..QQ...QQQQQQPQQAQQQQSQQ.GPQQQ
 2222- 2303 (138.10/34.23)	PQQQQgnpNMG....FV.....GNV...NQMN...............Q...............M.....AGQGA.GGQ.Q....WG.G......Y...N...........P................................MQQQQQ..Q....Q.SQQQQAQ...QQ..SQpqpQSQQQQSQQQQQQQQQQaGPQQT
 2305- 2401 (114.47/27.13)	PQ........QGAQ.QG.....PQQ...GPQQaSQQL.........QQQ..QMY.YGQ.....G.....MGQGPINRYdRP..ALN.N......P...KqalsnmlrskiP.MNAG.hpgF......................MQQQQQ..Q....Q.QQQQ...............AQAQRNPQQ...QAFIR.GPM..
 2402- 2461 (53.32/ 8.77)	..R.A...GMPGNPvVG...npGAM...GPMN.P............AMAGGGAG.LGT.....A.....AGVGGSGGG.AG..GAG.GnvaagvM...G...........GGQQ......................................................................................
 2577- 2686 (47.18/ 6.93)	........GMGGN..VGgmgtsGGMvtsGGMV.TGGMgnsgigtatAMGGGQGA.MGN.....SgmannAGMGNPGMA.NP..GMGmG.....nMqqqG...........GNMQGG....MfqgqnvpyqnvnqnypnygnqgMG.QQG..G....Q...........................................
 2688- 2776 (106.79/24.83)	........GMMGN...........F...NPMA.QQ............QRNTQAEfLAQqqralA.....AGRGQYGQH.APnvTMG.N.......................................................MGVNQGavP....P.YPRQGGK...PG..VG...GNIPQTQQQFQQQQRLR.LMMQQ
 2777- 2836 (45.11/ 6.31)	QQQQQqqsGMG....QG.....GN............................................................................................................aqgliqnqgqgMNTQQT..PnlvaQ.LQRQMPN...QNnmMG...QQYPHQPPQ..............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     122.16|      23|      27|    2483|    2507|       2
---------------------------------------------------------------------------
 2483- 2507 (41.88/20.28)	AGMMNQNSAGLMGSSGAsiMGQSGG
 2512- 2533 (39.50/14.52)	ANMLNQQNPALVVGQG...MGSGGG
 2555- 2576 (40.78/15.24)	SGMVTGN.AGMGGNAGG..MGSNAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.19|      18|      71|    2462|    2482|       3
---------------------------------------------------------------------------
 2462- 2482 (26.25/22.73)	GGMGaAGMMGvQQGGQGpPGA
 2536- 2553 (35.94/16.18)	GGAG.AGASG.GGGGAG.IGA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     129.44|      38|      72|    1868|    1905|       4
---------------------------------------------------------------------------
 1868- 1905 (68.74/38.15)	LADKQRVSV.WDLLEGHKNPAPLSWAWFGAVKIERKPLA
 1941- 1979 (60.70/32.82)	LPDKLKDEMkADTPSSDQSPAPSTSSKKGKTVRKRKPKA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33604 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DLDKLLQHIKEDQQNSMDAPDSPKDPEHASASVGTGL
2) EHYHHGPLQEKPSSGMGSTGGVSLNNSGGASALGMSSASGGSNPTTIPPPLSSPAGSMHSPAGSNSAAGGAMHSQQQQQQQLQQPLSPQEEQRL
3) GLGTGPISNKPATSSSPNNPSGMDDDVLQTDF
4) GNSGMANNAGMGNPGMANPGMGMGNMQQQGGNMQGGMFQGQNVPYQNVNQNYPNYGNQGMGQQGGQGGMMGNFNPMAQQQRNTQAEFLAQQQRALAAGRGQYGQHAPNVTMGNMGVNQGAVPPYPRQGGKPGVGGNIPQTQQQFQQQQRLRLMMQQQQQQQQQSGMGQGGNAQGLIQNQGQGMNTQQTPNLVAQLQRQMPNQNNMMGQQYPHQPPQY
5) LPLPPEEVDPLPDKLKDEMKADTPSSDQSPAPSTSSKKGKTVRKRKPKATAASQAAQNQAQAQPVMPALAATNAPQQMQQMQQQQLQQQQQQQHTLQQQQQQQQQHLQQHQQQQQLHLQQQHLQQQQ
6) MFSKHKDGNGGNNSSNNNSHSHGANSNSSVSSNGSTFA
7) MNMRPLKRPRLGPPDVYPQEAKQREDELTSVHVKH
8) NVNLHASEPDSTGGSKVSPDVAEPKDGKNDKMSNGG
9) QQQQQQQNQLMMQQQQQQSNLGQQQNNMQQQLGAQQQVGMTPQQTLQQMQNNNMGGMQMGGSMNPMNQQHLQQQYGQPNAGQMVGQGNIGGMQPGMGGMGPGMNASLMQQQQQQQQQQQQQQQQQQQQQQQQPQQAQQQQSQQGPQQQPQQQQGNPNMGFVGNVNQMNQMAGQGAGGQQWGGYNPMQQQQQQQSQQQQAQQQSQPQPQSQQQQSQQQQQQQQQQAGPQQTGPQQGAQQGPQQGPQQASQQLQQQQMYYGQGMGQGPINRYDRPALNNPKQALSNMLRSKIPMNAGHPGFMQQQQQQQQQQQAQAQRNPQQQAFIRGPMRAGMPGNPVVGNPGAMGPMNPAMAGGGAGLGTAAGVGGSGGG
818
195
772
2621
1931
1622
1
380
2074
854
288
803
2837
2057
1659
35
415
2443










Molecular Recognition Features






MoRF SequenceStartStop




1) MNMRPLKRPRLG
2) RKRKPKATAASQAA
1
1973
12
1986