<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33603

Description Mediator of RNA polymerase II transcription subunit 31
SequenceMCVCERAAPDVKILAFKRRRVKSKKEGKTGAEITFSWGFRQQSYYKSDPCCPCRKIPRAGASGVHRKLGRNNGSHERRRMVMMNPYGLAVESEDAQKLRFQVELEFVQCLANPNYLHFLAQRGYFKDAAFVNYLKYLLYWKEPEYAKYIKFPMCLYFLDLLQYEHFRREIVSAQCCKFIDDQAILLWQHYTRRRTRLTALGTTSLTGLAVGGQPVGGGVQGTLLSNEPSIMASCNNGNNGSQNSSSNNGTMSGSGGLMNSNSMNSNNGPNGAGGGVNLPPSSTQQSIAQNGGASMTQHNGVGGLLMGNPLGSLGSGAAGGAGSVTGGGSINQKVP
Length335
PositionMiddle
OrganismAnopheles darlingi (Mosquito)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.08
Grand average of hydropathy-0.417
Instability index37.30
Isoelectric point9.57
Molecular weight36260.80
Publications
PubMed=20920257
PubMed=23761445

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription, DNA-templated	GO:0006355	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats
>MDP33603
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      73.12|      14|      16|     246|     259|       1
---------------------------------------------------------------------------
  225-  238 (21.21/ 9.50)	SNEPSIMASCNNGN
  246-  259 (27.29/14.61)	SNNGTMSGSGGLMN
  265-  277 (24.62/12.36)	SNNGP.NGAGGGVN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.79|      20|      23|     147|     168|       2
---------------------------------------------------------------------------
  149-  168 (38.97/38.18)	IKFPMCLYFLD...LLQYEHFRR
  170-  192 (33.82/23.18)	IVSAQCCKFIDdqaILLWQHYTR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.03|      18|     107|     200|     218|       3
---------------------------------------------------------------------------
  200-  218 (29.81/16.02)	LGTTSlTGLAVG.GQPVGGG
  310-  328 (29.22/11.99)	LGSLG.SGAAGGaGSVTGGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      26.95|       8|      16|     106|     119|       4
---------------------------------------------------------------------------
  106-  119 (10.90/18.59)	FVqclanpNYLHFL
  130-  137 (16.06/ 7.15)	FV......NYLKYL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33603 with Med31 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) CNNGNNGSQNSSSNNGTMSGSGGLMNSNSMNSNNGPNGAGGGVNLPPSSTQQSIAQNGGASMTQHNGVGGLLMGNPLGSLGSGAAGGAGSVTGGGSINQKVP
234
335










Molecular Recognition Features






MoRF SequenceStartStop




1) ILAFKRRRV
13
21