<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33601

Description Mediator of RNA polymerase II transcription subunit 7
SequenceMANAEAIQVSSLPLPPAQYINLYTDDNIRKNRAPKPPAPIQDAYTMFGSPFNNDDNIIRPLEIQGFKRLYPQHFDRRKELKKLNHSLLVNFLDLIDLLVHYPDSPRRAEKIDDLNLLFVHIHHLLNEFRPHQARETLRVMMELQKRQRIETAQRFQNHLEKVREMVKNAFASLPDLTDADRMGGGLEPMDVGEAGDLAGGRGEGCHPLDRLMCEIVDRM
Length219
PositionMiddle
OrganismAnopheles darlingi (Mosquito)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.06
Grand average of hydropathy-0.557
Instability index46.88
Isoelectric point6.31
Molecular weight25253.68
Publications
PubMed=20920257
PubMed=23761445

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33601
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.54|      20|      26|      26|      51|       1
---------------------------------------------------------------------------
   26-   51 (32.25/31.30)	DNIRKnrapkpPAPIQDAYTMFGSPF
   55-   74 (36.29/20.33)	DNIIR......PLEIQGFKRLYPQHF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.52|      18|      26|      87|     106|       2
---------------------------------------------------------------------------
   87-  106 (27.83/17.87)	LLvnFLDLIDLLVHY.PDSPR
  116-  134 (29.69/13.84)	LL..FVHIHHLLNEFrPHQAR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.79|      11|      18|     180|     190|       3
---------------------------------------------------------------------------
  180-  190 (23.33/14.39)	DRMGG...GLEPMD
  196-  209 (18.46/10.10)	DLAGGrgeGCHPLD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33601 with Med7 domain of Kingdom Metazoa
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