<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33530

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMPPAPSPDAAAAAALAHAPPHIHTRAPVLAARLPLPRRTRVHYALFAAAPDLLELARRHVLPRTPTPPLASVLVSVHVGPDTPRLYAFLIASDDDPARARAPLDALARAPPFLALALTEAASFTPDDLYPCSPACAAQRTPCPNCLDPAAPRPPHPPPPPPSAAPSAPLLPREPLRAVYAHFLDAVRDRLIDDMCVHVPAAPHTHDHDPRRLSRLQNGVLIIPDGGPRDWGLGWEHHVQNRPLIHCALHLHLSPARILVQPVFRPTHFLPLPAALPLPPGTPITLLPYATPAYYLSTYAGPTAALTSQFSQSLAGKGCGPWAGTSPPPPSPPSPHPSRVDPHPHPAPSFSSASAPPTYIIAWLAVQNGRGEDKGLPLIWPAALALASIPSTITGAAHRPPLHPLPELPAQLQPSPPPPPPPPPLVSFGAGSARSTPQPSQSAAIGAPLPTSSLPLPVLPQQQQQQQQQQQQHTAPSSTQPLLPPAIARRTRASPTADALRVFRTLSIGGGRSVRAVADEVAAYVDAVQRERERERERLRRERETVNGGGGARAPSPAQAGTPTAPPPPLAPTPVPAASTQPFYPSPPQSGNVTATGAPSLLAGTTPTPTPVPAPPAPAPALAPPPASASAPPPAPEPAPELDPEPATFDPGVFGELDAWTPADAVWAQGAGDFMDIGLDGVGGMPYGVRGDVGGAFGVGVGVGVDTMGGLDPVAGGAGGGWDGGMDIDAGMDDIFTEADFDFWDAKPQAGAPAVASRPMDVGPPPSAGPVSLGLSPPPLFGESGPGPPGAASPTWAASGVFGDGFAPREPRTESSVPPELLPPSPTRTPESHAGPATPAVHVALAPEMQTGSGPSAWDPIPFARAHRIADGKYTAGKFALPSPPDEEDRTRPLPVPLQPPFAASTATATAAAGEPGWRKRYYNAVTDPSVGMVRKLIGVKRKSFDQGARAPAFRMSAAWVRGDDEWESNVVQDRAADVALWGRSDDEDGDSDEQEEEEDEDGDDDEREREEGPWAREDEPMLPGTRPATPPPAYLPLGPTLLHTQFQHALLLPLSAPLRAPGSAAASPPSLAAASAPTSVPTPVSPAALAGQTSDRLKSLEAAAQVLVREVVESSVWGDAWRANAEEYLAGCRLVTEVWQADVRRIARALGGVAGVEGPLDLCSVFAPAPAPTPAGGEGAPPPPPPPPPRLQVCEPPMLAVGKADAIIQVLPTALKFWEKLGLGPRAGKKDVVAFVFFEDDRPERQDWAEQWLACISTSYVAKNLGSHTAGRNAGCVRDGIVPVKFDAFRRTLTTFVASLPASTANYVFYIAVPASILSLSSPVLRQIFSAVKRAQKRYSEAQILFQFLPAHLVHCVRYPAASQCGFLVPFAMCVYERILRPVDRVMSRRFFDHGERVRNFFQEPAVLLARPAHGTAHLIREFSPRALDVLERHMLLHVGYRVSACGRWIFAACLDQRGEAHDLGAWLSQSEPSPEAHLVQQLWRFALNFAKKASVEWRIVFAKLGSMDPAELDAWMEHLASAVPDCAELPMVHVSLLAVESDASWTFIAPAGAAKRPMSPSRSSKSTAGTFFHDVSATTYFLSHASGACLLPPGHAACDLGAGVPYIPDPADAPPRSPAPLPMRPLRSTTLVRAPAHTDYTSISMLHLHLLHTAKSARSSLAIPDAETHDDITRNYHDLAVLAQARWWLKADPILPFHLGALQVMAMALSRCDLPMLA
Length1719
PositionKinase
OrganismHeterobasidion irregulare TC 32-1
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Russulales> Bondarzewiaceae> Heterobasidion> Heterobasidion annosum species complex.
Aromaticity0.07
Grand average of hydropathy-0.179
Instability index60.40
Isoelectric point6.05
Molecular weight181859.56
Publications
PubMed=22463738

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33530
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             9|     771.90|      89|      90|     269|     357|       1
---------------------------------------------------------------------------
  106-  183 (64.96/ 9.67)	........................LARA.....PP..FLAL...ALTEAASFT...PDDL..YP......CSP..AcA.A.....................QRTPC...PNcldPA.APRP......PHPPPPP..PSA..AP.SA.pLlprePLRAVyahfL
  184-  275 (88.54/16.70)	D.............AVRDR.LIDDMCVH.....VPAAP.HT...HDHDPRRLSRLQNGVLIIPD......GGPrdW.GlG.....................WEHHV...QN...RP.LIH.C..ALHLHLSPARILVQP.VFR.PThfL....PLPAA....L
  276-  363 (158.46/37.53)	P.............LPPGT.PITLLPYA.....TPAYYLST...YAGPTAALTSQFSQSLAGKG......CGP..W.A.G.....................TSPPP...PS...PP.SPHPS..RVDPHPHPAPSFSSA.SAP.PTyiI.......AW....L
  364-  458 (90.29/17.22)	A.............VQNGRgEDKGLPLI.....WPA.ALAL...ASIPSTITGAAHRPPLHPLP......ELP.aQ.L.Q.....................PSPPP...PP...PP.PPLVSfgAGSARSTPQPSQSAAiGAPlPTssL....PLPV.....L
  459-  559 (71.72/11.69)	PqqqqqqqqqqqqhTAPSS.TQPLLP........PAIARRT...RASPTADALRVFRTLSIGGGrsvravADE..V.A.A.....................YVDAV...QR...ER.ERERE..RLRRERETVNGGGGA.RAP.S..........PAQ....A
  560-  633 (85.97/15.93)	G.............TPTAP.PPPLAPTP.....VPAA..STqpfYPSP.....PQ.SGNVTATG.......APslL.A.G.....................TTPTPtpvPA...PP.APAPA...LAPPP..A....SA.SAP.PP.................
  679-  778 (64.27/ 9.47)	D.............GVGG......MPYGvrgdvGGAFGVGV...GVG...VDTMGGLDPVAGGA......GGG..W.D.GgmdidagmddifteadfdfwdAKPQA...GA...PAvASRPM..DVGPPPSAGPVSLGL.SPP.P..................
  779-  835 (58.09/ 7.63)	.......................LFGES.....GPGP..PG...AASPTWAASGVFGDGFAPR........EP..R.T.E.....................SSVPP...EL...LP..PSPT..R.TPESHAGP.............................
 1020- 1093 (89.60/17.02)	P.............MLPGT.R....PAT.....PPPAYLPL.....GPT.LLHTQFQHALLLPL......SAP..L.R.A.....................PGSAA...AS...PP.SLAAA..S.APTSVPTPVSPAA.LAG.QT.................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     207.53|      61|     210|    1189|    1253|       6
---------------------------------------------------------------------------
 1189- 1253 (101.85/74.28)	PRLQVCEPpmlAVGKADAIIQVLPTALKFWEK...LGLGPRAGKKDVVAFVFFEDDRPERQDWAeQWL
 1405- 1468 (105.69/64.71)	PAVLLARP...AHGTAHLIREFSPRALDVLERhmlLHVGYRVSACGRWIFAACLDQRGEAHDLG.AWL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.15|      19|      21|    1111|    1131|       8
---------------------------------------------------------------------------
 1111- 1131 (32.22/24.99)	VVEssVW.GDAWR.ANAEEYLAG
 1135- 1155 (25.93/13.17)	VTE..VWqADVRRiARALGGVAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.01|      17|     530|     634|     650|       9
---------------------------------------------------------------------------
  634-  650 (32.86/ 7.80)	APEPAP.....ELDPEPATFDP
 1167- 1188 (29.15/ 6.04)	APAPAPtpaggEGAPPPPPPPP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33530 with Med13 domain of Kingdom Fungi
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