<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33524

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMALNGTNLTASTSQLPQPSSDFIDGFIPYTNGFDEPPIEILEQELPVVLDGQVPLGEVVSRVAQACYAELSEMAETLPSMSDSARKRKLADFVVAWKKQIVKLYAVAKWSRDANVVQKCMNITAFLMNQNRQFEDVIEGLKYAKSSLDPARLRNHDLLTSLDVLTTGSYRRLPTGIKKAIVPPTPLTDEQVAKTLSDIESLIRYRLRMREIIPIEMSKYRIHDGRVFFRVPKFFEMSLCLRGGNEDDGWFFVHVEFLFNVGGDPTGMQEFPQKPTGVLKRHITDEADARLAYYLPLPADLPPPPPGVNLPPVPHLPEGTVDAPLVRVFNFLQMMSMSYQLEILWYQAERMRSLGWADFLTVEMSRDRKTLTVSYWIRKPPPMMRTKVPLLGGTVSIALMSTPGPRRSPTARVLAELQEKSKMSSSSKRPSDPVEGMQWHVKWQPEPGALGVKILPDDGLLADGEVAVDASDLDFERLLRQVIEKHTRAIFRVLYMRLQRGPVFSVPNAVTVSEIDGHIALNVHLCADEHIVVTIDPRTGRLNARDIGDISATGRGPRFAAFSKNLNEDSSILLEALMRLRILTIISLAEQKATYLGLQTHRNKNFPNEELVKLGPSARGYLFIKLTPFPNHHLVLVVMDDDFRYALISVKAVLKGMYQKLVMEDIGWLNVERICAHGREVDIAENEVSLGKRKRDAGMDSKASTKFKLETQVLRELYAYCCARVAHTKVEQQFKARGIPYNHIYPSSPALTPSLPASLAHLHSALSHKIPALCVKSSDILSGSPAFEAAMPNIRVIPLSWWSVSASAGVVTCVKLKYVQQPVGRRARLGKGVIRPSKRIVYDANEAVVCFLSEKVEGCVDEFLEEWASVSKIVVIAREVAEMAKEKRWEDVRILSFDLQTIEFAYASDYTVSITCTDQLSATGGSYNLHFSRQLPPSPINASGPSIASGGALNSHSYTSTSNSFDDLFDAQSPSSGRAFNPHSDAVSFLRHILRQGKLSATLPTLVALLRDTVPVVEVIEEIRAWAEQRNSRVDVDAFPKAAGWWRVQFSVTPSAASAPASGVMRQRYGLDMRLMKGERVAMLDAARSLFLPFSSAASSTTAPASSSSRPGALGALVLQPIPGFQQIVEHALRDMKGARIAVVDVAVVCAVKDLRAVGRRVWEAVCRELGTGASASAGASAGTAAGAVGGIGMSPGKAKAKGTVRAGAIPMPIPVGSQVG
Length1220
PositionTail
OrganismHeterobasidion irregulare TC 32-1
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Russulales> Bondarzewiaceae> Heterobasidion> Heterobasidion annosum species complex.
Aromaticity0.07
Grand average of hydropathy-0.087
Instability index47.47
Isoelectric point8.96
Molecular weight134120.10
Publications
PubMed=22463738

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33524
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.93|      16|      21|     223|     243|       1
---------------------------------------------------------------------------
  223-  243 (26.08/34.32)	DGRVFFRVPKFFEMslclrGG
  247-  262 (32.85/25.04)	DGWFFVHVEFLFNV.....GG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.62|      22|      73|    1099|    1120|       2
---------------------------------------------------------------------------
 1099- 1120 (37.39/26.26)	STTAPASSSSRPGALGALVLQP
 1174- 1195 (37.23/26.11)	SASAGASAGTAAGAVGGIGMSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.71|      12|      79|     600|     618|       5
---------------------------------------------------------------------------
  600-  611 (22.52/28.91)	HRNKNFPNEELV
  623-  634 (23.19/ 8.42)	IKLTPFPNHHLV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.27|      19|      21|     363|     381|       6
---------------------------------------------------------------------------
  363-  381 (37.42/25.66)	MSRDRKTL...TVSY.WIRKPPP
  382-  404 (25.86/15.19)	MMRTKVPLlggTVSIaLMSTPGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.35|      11|      19|     859|     869|      13
---------------------------------------------------------------------------
  859-  869 (20.00/13.51)	VDEFLEE..WASV
  879-  891 (15.36/ 8.59)	VAEMAKEkrWEDV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33524 with Med14 domain of Kingdom Fungi
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