Description | Mediator of RNA polymerase II transcription subunit 4 (Fragment) |
Sequence | LEDGRRELEAIVTEGDTRIGEIHRAREAAIPYPELLAYAQSLSAFTSAPPNMPETAPPGLPQAPPPLFFPPFPNEEKMRRGHLNAEAPLGVPGETHSVGRRTSSRSPSPSSPTDQLAHAHANPYRPHDSRPPVEIFDLDLDLNPDL |
Length | 146 |
Position | Middle |
Organism | Heterobasidion irregulare TC 32-1 |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Russulales> Bondarzewiaceae> Heterobasidion> Heterobasidion annosum species complex. |
Aromaticity | 0.05 |
Grand average of hydropathy | -0.688 |
Instability index | 82.00 |
Isoelectric point | 5.15 |
Molecular weight | 15950.55 |
Publications | PubMed=22463738 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP33522 No repeats found No repeats found |
MoRF Sequence | Start | Stop |
1) AHANPYRPHDSRPPVEIFDLDLDLNPDL 2) APPPLFFPPFPNEEKMRRGHLNAEAPLGVPGE 3) PELLAYAQSLSAFTSA | 119 63 33 | 146 94 48 |
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