<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33514

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMNPLLPPGPADLKELTSRCIDRSYDSLYNLTTSLPNTASEERRGVALKQLQDTHAVFKKLLVLTRWSVQSPLADKCAELLQEAQTFQDQANETNDRLYFLHRDLDRAKERQYDLTTAIDVLYGGTYTRLPRVINYAMHPREFPPVDEETSIAELDAVLRFRLIEETIPDKFTHIDVHEGFVTAGTSGEFEMVFTVDGTKPDSLWLVASVQTVLTDPVAQATFKHLASTSSLRIIQSNAPTDVHYMQLKILIQKRLNQSATPLLDACNIMSDFCCSLALRILHAQGQLLVDTRWPHGVSFLHQDHHDTATLDIVYWTDATAPYVAASTPGTFSLEEMRNRMHPDALRYPAAGCCVRLQPNTTKDKATVGLFSLQLFPAPPSMLLQRYPALVPEALAVPTNLYGLSADHFLLGAMDVHAASALFCLEQHLLVQTNTDQEEDDGAELRWLTTGERVRVTRSSPRNLRIARVDSSGRAPLEVSWDMRTGRFGVFCLAQASSVAAAVAHLETLLHTTVKVQLPGVTVAGEFALVFASNDDVAAAVAAVLRLVVAFELEAFASGCANLPVVRVRDRHAAAVDAAGVASDAVFVELVRGKDATVYLVVELDTVADTTLDKARKRRRRCRRRDSDGLFSLGPPAFSILHVVDEPHRPSASSSSSVRCLERLPTPGYVGTKKRKRRDVPSLSALLLDMAAVGRQRAQWHLLDAFATKYNVLLTTNSTLSTTTDDGSVELASSTPSSSSLWTVSCPFPDRLHTAPHVDVHRLEARVFPDSSVEVTVHVGSSPFAYISPQGSLSGGRGGGRGSFVATALPTGDLVYRRRWTNQKFQLPLMDVVVANVMLHVKPMAELGRRLERTLLSSLNADGVGQIYAERADPFKFTLACRGWLPRCQSSSSQSLMICDDVIMRVHVEHKVMHQYPRGAFVLTTAPSHALLPFLQDALNTHKSTAQLVEVLERTAVPLVMLSRALTAAYPAAVVPSNFVLVPRSQTHLRLTYADRCAVDVVFLADQKINVRSAPSSLVPVPSCAMAGGLLLDHASFYDTVRRSLVPEMAAL
Length1051
PositionTail
OrganismAphanomyces astaci
KingdomOomycetes
LineageEukaryota> Sar> Stramenopiles> Oomycota> Saprolegniales> Saprolegniaceae> Aphanomyces.
Aromaticity0.07
Grand average of hydropathy-0.037
Instability index49.50
Isoelectric point6.73
Molecular weight115506.74
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33514
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     152.63|      48|     225|      11|      66|       1
---------------------------------------------------------------------------
   11-   66 (66.88/72.94)	DLKELTSRCIDRSYDSLYNLTtslpNTASEERRGVALKQLqdtHAVfKKLLVLTRW
  246-  293 (85.75/63.15)	QLKILIQKRLNQSATPLLDAC....NIMSDFCCSLALRIL...HAQ.GQLLVDTRW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.62|      15|      18|     756|     771|       2
---------------------------------------------------------------------------
  756-  771 (23.67/18.48)	HVDVHRLeARVFPDSS
  777-  791 (27.95/16.95)	HVGSSPF.AYISPQGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.08|      30|      36|     484|     517|       3
---------------------------------------------------------------------------
  484-  517 (41.14/35.84)	T..GRFgVFCLAQASSVAAAVAhleTLLHTTVKVQL
  521-  552 (43.94/25.09)	TvaGEF.ALVFASNDDVAAAVA...AVLRLVVAFEL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     144.64|      36|     227|     325|     369|       4
---------------------------------------------------------------------------
  328-  363 (69.34/40.38)	PGTFS.LEEMRNRMHPDAL..RYPAAGCCVRL.QPN..TTKD
  370-  392 (24.85/16.23)	...FS.LQLF..PAPPSMLlqRYPA......L.VPE......
  634-  673 (50.45/22.79)	PPAFSiLHVVDEPHRPSAS..SSSSVRCLERLpTPGyvGTKK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     140.30|      42|     429|     424|     465|       6
---------------------------------------------------------------------------
  424-  465 (72.09/51.79)	LEQHLLVQTNTDQ......EEDDGAELRWLTTGERVRVTRSSPRNLRI
  850-  897 (68.21/48.55)	LERTLLSSLNADGvgqiyaERADPFKFTLACRGWLPRCQSSSSQSLMI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33514 with Med14 domain of Kingdom Oomycetes
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