Description | Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MTGTIREGVEISLNEHRFLTYKLLESLSHTSANVNPAMLRSTNDYFDMVVAKDKQLLRTVKQLNQHQTAQKELDALKAQIADKEQKIVRYAKELRSGQQSIASVLAKHRRTLTQCAQDAASKVVLDPLDIVAYAHKIAGSTSAPPNWQPEYPMFGFVPPAPTPEMMRAGVLSRGSTSRATYFAVVLVPSTSFNPDIYLYILSDILVIEATVTKESSYEAFKKGQQADLASPLVEGGVGGAISYASLGGGAADNGLIPGWKEGEVELSVEALVKLRGLSVFAEYDVALPGHLRPTDPIPADALEALRVKVEAQRKRKAEHAAANNGPDAKKFKQGDAESSSSSSDNGASSDEESEESEAEKVQTIRWSLSDDEDSDD |
Length | 376 |
Position | Middle |
Organism | Aphanomyces astaci |
Kingdom | Oomycetes |
Lineage | Eukaryota> Sar> Stramenopiles> Oomycota> Saprolegniales> Saprolegniaceae> Aphanomyces. |
Aromaticity | 0.06 |
Grand average of hydropathy | -0.389 |
Instability index | 40.19 |
Isoelectric point | 5.21 |
Molecular weight | 40765.22 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP33513 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 52.33| 16| 69| 250| 267| 1 --------------------------------------------------------------------------- 250- 267 (26.78/18.70) AADNGliPG...WKEGEVELS 321- 339 (25.55/12.31) AANNG..PDakkFKQGDAESS --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 49.92| 15| 15| 89| 103| 2 --------------------------------------------------------------------------- 89- 103 (24.21/15.17) RYAKELRSGQQSIAS 107- 121 (25.70/16.48) KHRRTLTQCAQDAAS --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) KVEAQRKRKAEHAAA 2) PDAKKFKQGDAES 3) SSDEESEESEAEKVQTIRWSLSDDED | 308 326 348 | 322 338 373 |
© 2021 Shailesh Lab
Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab