<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33511

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMAAQADMQVDLGVDDLFGDDAMNLQTRPSKRLLQRINELRTRGACQSLAWSKTGIIATVAPDGRSIELRYLRAHPKDASWGLSEPTTFVPEGSLLGGPIVHLAWSPTQTSDLAIIDAVGRVLIVNFSANVNRPTTQRKWDDDPTDDLNAVVGTFWLNLLPTHRNQANPLHAPAYKEGNSNSYTFDTSLQVSNAPYHPNPTRSALVYVTTNGLLKMFWSQNNNKIQETSFELDNITSSNDLVTHAAIAPDTKAKCMWVAFATSSKQLHLAQCQLSWGLSQETMKGAMAAGQSLNPSFAGKHVAITSWLPGNTTEPPSESLANQLSLLEFVPGTFDQTTKSWLWPVILAVRSFVPTADTPYNQEAQSIIDRWEVTSDQPQTLHPAFENLGSRRNSVGAAPAPAFRLKKLEPVVVNKIAVGISLVRLNTAICVTYSDGTVEYRDRTTLNPLWTEVNLDRINSIHEAGFTQNGEQSCLQAAVSATLASVVQLCEDNTVKWHTVAYTLTDLASMNDSQYQAVVAALTISIGQAAASNGNIDDVLAVARQFLGKTRFPCDLISEMVRMMRVPIDYSEEPHHDTLVRNQLLQLCLSVLNHLGWNGEFQERSFRSKMAMFALNLRNIVILITIANNAPGHMKNTTPLDEPEVVDALAGCCKWSIDLLCWIVDSLFCLLNDQKFQDHFTTPAKYSEMTPYLLAKKNIALHMILSSSIRGLLSAVCRRIQHLQFISHKTINYYETMDTNTTNPPPAALQVAYQKMLRYTSNPLVNVSKFDELLTTIGTDIKQQYTQQFAQFSHRAMEAAKKTQPNPPKSIGDDAIKRAQLHCEMTMLLGNAPPLPLLTVLKKFFQTDLPQFRAFCQPSELFFANYNLLEVDDDEVVLAARRERGARVDLFKRVEIFRGKKLTNSSGEEVAVDWRRCSRCASVMEDVIPFVMAKPGIAFVLSQQRFCACGGKLAILKKNELVG
Length962
PositionTail
OrganismPestalotiopsis fici (strain W106-1 / CGMCC3.15140)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Xylariomycetidae> Xylariales> Sporocadaceae> Pestalotiopsis.
Aromaticity0.08
Grand average of hydropathy-0.169
Instability index38.07
Isoelectric point6.61
Molecular weight106864.85
Publications
PubMed=25623211

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33511
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.25|      22|      53|      43|      64|       1
---------------------------------------------------------------------------
   43-   64 (40.96/29.81)	GACQSLAWS..KTGIIATVAPDGR
   97-  120 (35.29/24.59)	GPIVHLAWSptQTSDLAIIDAVGR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     120.00|      36|     150|     217|     253|       2
---------------------------------------------------------------------------
  217-  253 (56.07/39.87)	WSQNNNKIQETSFELDNITSSNDLVThAAIAPDTKAK
  370-  405 (63.93/40.60)	WEVTSDQPQTLHPAFENLGSRRNSVG.AAPAPAFRLK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     175.13|      55|      62|     536|     596|       3
---------------------------------------------------------------------------
  536-  596 (88.66/75.70)	DDvlavaRQFLGK.TRFPCDLiSEMVRMMRVPIDYSEE.....PHHDTLVRNQLLQLCLSVLNHLGW
  601-  661 (86.47/58.88)	QE.....RSFRSKmAMFALNL.RNIVILITIANNAPGHmknttPLDEPEVVDALAGCCKWSIDLLCW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.59|      31|      32|     275|     306|       4
---------------------------------------------------------------------------
  276-  306 (54.23/38.62)	GLSQETMKGAMAAGQSLNPSFAGK.HVAITSW
  309-  340 (49.36/27.89)	GNTTEPPSESLANQLSLLEFVPGTfDQTTKSW
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33511 with Med16 domain of Kingdom Fungi
Unable to open file!