<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33506
Description |
Mediator of RNA polymerase II transcription subunit 17 |
Sequence | MASTSPSLFTLRPWPRGDKKPKKLGEFIARVNAERGGFRNVTEMELREELHAAEDGRNQSAASSPDSDSDMDVDSDGAKSKTTLEAREEFLRNIEFAHQSAMLSLDFVSLLLSKETPNQANTTLSPALRDLVGFGVLGASRLQDSNITPARTQDDLAVATGWRLIGTNKMVDSVLEAAERLEKEISLETKYWADVLAVSDNGWTVTSLPYDPHTLGVRYGFAESAPEYRNSSIAPLRRNDDGTVRLERGVSGGSSKRVRAVVIKNGQVTGKSRLPGQVDEKAPLQDRVLEARNTIFSQELWYEINKEARTLLSLKVQSIDDQIIYEADPETKVILTLEDLDAPDAGGDLPDNQFANTVVLGLHFLLLFSHRLSYFKRTQSTQTTTGREAPPLSILRPLISRLTYDNACTKLTYFLTKLKTILQNAGFSTADFTQTMIPPGPQLPPQQIAQLALQQIWRASPSEALIINLAQLLELTAELTFTPQARIGLRGRSFVTPMASTQFMVFLPGASNNNPAAQGQNPAPAQTKSNELEELYPPYSQDAYPNVDEAIYYIRQASVRVIVDWVASLAAEKLGRDDLDWSETTSGAVIRALGKNEVRLDITDSPDLALRLQMRWVENRDVKQRNVTWAAGQESKETLEQLVVDFFRQ |
Length | 649 |
Position | Head |
Organism | Pestalotiopsis fici (strain W106-1 / CGMCC3.15140) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes>
Xylariomycetidae> Xylariales> Sporocadaceae> Pestalotiopsis.
|
Aromaticity | 0.07 |
Grand average of hydropathy | -0.385 |
Instability index | 41.86 |
Isoelectric point | 5.18 |
Molecular weight | 72069.32 |
Publications | PubMed=25623211
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364140
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP33506
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 137.24| 38| 38| 59| 96| 1
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34- 56 (24.71/11.52) ...............ERGGFRNVTEMELREELHAA.EDG
59- 96 (62.28/40.13) QSAASSPDSDSDMDVDSDGAKSKTTLEAREEFLRN.IEF
99- 134 (50.25/30.97) QSAMLSLDFVSLLLSKETPNQANTTLSPA...LRDlVGF
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 81.77| 27| 38| 136| 162| 2
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136- 162 (47.67/30.96) VL.GASRL.QDSNITPARTQDDLAVA.TGW
174- 203 (34.10/20.13) VLeAAERLeKEISLETKYWADVLAVSdNGW
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 43.13| 13| 21| 302| 314| 3
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302- 314 (21.18/11.96) YEINKEARTLLSL
325- 337 (21.95/12.61) YEADPETKVILTL
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