Description | Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MDVQMAARFERVEKALATLIDSVSRYNPTISQGNELVAADQELGKGLEELKVHQQNYERIQRLRSVTNGLDSQIKDTLTQLAQARKELGNTPATSFPSGPNYPIKYDELLAYARRISKTTMPNANVLAAAQANAIESAAKPDSGAETPNVPTPVAGTPNGVGTPAQVNGAASTPAMSGDPASQQTNATLPEGLQAHLNPLANIDFLPWPSEDLLRQGALANIQFLQDQGINPQGYDPAAEEARKKREEEEAKEREEQERLQREENERKFREQRERARIEEEKAREESFRRASVSQAQAGATSGAGSSPPPPPPQQQKQFQFMGGDDDDDDSD |
Length | 332 |
Position | Middle |
Organism | Pestalotiopsis fici (strain W106-1 / CGMCC3.15140) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Xylariomycetidae> Xylariales> Sporocadaceae> Pestalotiopsis. |
Aromaticity | 0.05 |
Grand average of hydropathy | -0.903 |
Instability index | 57.39 |
Isoelectric point | 4.81 |
Molecular weight | 36300.43 |
Publications | PubMed=25623211 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP33505 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 60.81| 20| 23| 243| 264| 1 --------------------------------------------------------------------------- 243- 264 (26.04/26.64) RKKREEEEaKEREEQERlQREE 267- 286 (34.77/23.81) RKFREQRE.RARIEEEK.AREE --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 55.89| 15| 16| 144| 158| 2 --------------------------------------------------------------------------- 144- 158 (28.66/17.35) GAETPNVPTPVAGTP 160- 174 (27.23/16.12) GVGTPAQVNGAASTP --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 47.39| 14| 16| 202| 217| 3 --------------------------------------------------------------------------- 202- 217 (20.62/17.81) NIDFLpwPSEDLLRQG 221- 234 (26.77/14.05) NIQFL..QDQGINPQG --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 61.27| 21| 28| 71| 97| 4 --------------------------------------------------------------------------- 71- 97 (26.98/32.91) DSQIK.DTLtqLAQARKelgnTPATSFP 101- 122 (34.29/21.46) NYPIKyDEL..LAYARR....ISKTTMP --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) ESFRRASVSQAQ 2) QQQKQFQFMG | 286 314 | 297 323 |
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