<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33502
Description |
Mediator of RNA polymerase II transcription subunit 5 |
Sequence | MDIDMDMDIDMSTSLEQAGAGPALDQKHSIDEWEKFIALCILKRLDPEPFETYVTVLHSRHPLPPAAVADVFLKPQPTNRENLDPRVPRYVQILSEKRFIDTPSILKALYKHSTSHTQAQAVGHADPEVAQATPETRWKNSYGQEETIFYRLTKSVALGTGIKSFGDAIAVCKVVAKWMSLFTSAAAAFAQDIMGQAHSLQAKDDMEASRAAFVMMLLGVCENQTVLRALSGPSAKEARKALSESLSSFIPSIMQSGASQIAERLESFRTGTLASFEPLDKKNEAAKAEFDDLIDSTLGFDNLAVSELPVMNTRAGLYIYLNAALVGRPLIDDAFLYGYLQNRYNGDYQSCFIDLILASFDVLANAVFRSEGSRTAHLLRSYLINKLPVLLANLAQSLSTLFPPVTPQFCITTALSQVDTNAFPTLSAMFDISSSNNTFTDSVRQEFCWACCLHGLIPESAIEVLLGEITYQSLPEGGKWVKEKLVNECMSDSERIQGLVNELDKMDGNVGAVCQALAEVITRLCASKETITLKQLCSQLAKKPLSLDVILLFEKPITILHPLCELLDNWRYDEEQGEYQPVYEEFGSILLLVLAFVHRYNLDIADLGTRASDSFTAKLLSSGHLPRQYEDLSEQEKNQLGGWIQGLFDPDSGGLGDELMSSCTPQDFHLLISSLFYQTVLAFSTDRLTEDSLKSGVEYLVDTFLLPSLVMALTFLANHLRTSRAAEPKAVIRILQLILLTKQGSNEAQTMLSAVITIVAKPLEHALRSHQRHDPKNQDIEPLLKAIRDNTQVPPRTAGADSKELEAWTGTANGGLAASVRHTIQGLIQWSLHPGLNVMPTSYTHRQMIAALKMLGPRQLLRLILDEVKQSYSEAGSASYAYDIAMALVCAPDVTNQPPAPPPALMNDPNQQASSIQKRVALRQMLRWEAEDCKKIQKVDPALAEHIVRLHRKVEAQMHIVIQPAPAMMQTDLSLGLDENAAASLDDALAAAQGDVMVANDTGMDLDLGPDPSGMGLDMGGADGGLGLGDDDIFGSLGPVGGGADLLDGWDTML |
Length | 1054 |
Position | Tail |
Organism | Pestalotiopsis fici (strain W106-1 / CGMCC3.15140) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes>
Xylariomycetidae> Xylariales> Sporocadaceae> Pestalotiopsis.
|
Aromaticity | 0.07 |
Grand average of hydropathy | -0.071 |
Instability index | 41.45 |
Isoelectric point | 4.92 |
Molecular weight | 115383.48 |
Publications | PubMed=25623211
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Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364142
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP33502
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 81.65| 26| 370| 631| 665| 1
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567- 617 (30.48/19.47) LDNWrydeEQGEYQPvyeefgsilllvlafvhrynlDIADLGTRASDSFTA
640- 665 (51.17/24.40) LGGW....IQGLFDP.....................DSGGLGDELMSSCTP
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 94.03| 18| 21| 994| 1011| 2
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994- 1011 (34.62/17.13) GDVMVANDTGMDLDLGPD
1016- 1031 (30.82/14.50) GLDMGGADGG..LGLGDD
1038- 1051 (28.59/12.96) GPV....GGGADLLDGWD
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 59.97| 18| 22| 302| 322| 3
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304- 322 (27.47/26.32) AVSELPVMNTrAGLYIYLN
324- 341 (32.50/17.55) ALVGRPLIDD.AFLYGYLQ
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 123.53| 33| 363| 436| 474| 5
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436- 474 (49.93/50.87) NNTFTDSVRQefcwacCLHGLIPES...AIEVLLGEITYQSL
487- 502 (19.27/ 7.95) NECMSDSER........IQGLVNE..................
813- 848 (54.34/36.52) NGGLAASVRH......TIQGLIQWSlhpGLNVMPTSYTHRQM
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 89.25| 28| 537| 215| 242| 6
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215- 242 (48.38/31.74) MMLL...GVCENQTVLRALSGPSAKEARKAL
737- 767 (40.87/25.71) LILLtkqGSNEAQTMLSAVITIVAKPLEHAL
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