<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33502

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMDIDMDMDIDMSTSLEQAGAGPALDQKHSIDEWEKFIALCILKRLDPEPFETYVTVLHSRHPLPPAAVADVFLKPQPTNRENLDPRVPRYVQILSEKRFIDTPSILKALYKHSTSHTQAQAVGHADPEVAQATPETRWKNSYGQEETIFYRLTKSVALGTGIKSFGDAIAVCKVVAKWMSLFTSAAAAFAQDIMGQAHSLQAKDDMEASRAAFVMMLLGVCENQTVLRALSGPSAKEARKALSESLSSFIPSIMQSGASQIAERLESFRTGTLASFEPLDKKNEAAKAEFDDLIDSTLGFDNLAVSELPVMNTRAGLYIYLNAALVGRPLIDDAFLYGYLQNRYNGDYQSCFIDLILASFDVLANAVFRSEGSRTAHLLRSYLINKLPVLLANLAQSLSTLFPPVTPQFCITTALSQVDTNAFPTLSAMFDISSSNNTFTDSVRQEFCWACCLHGLIPESAIEVLLGEITYQSLPEGGKWVKEKLVNECMSDSERIQGLVNELDKMDGNVGAVCQALAEVITRLCASKETITLKQLCSQLAKKPLSLDVILLFEKPITILHPLCELLDNWRYDEEQGEYQPVYEEFGSILLLVLAFVHRYNLDIADLGTRASDSFTAKLLSSGHLPRQYEDLSEQEKNQLGGWIQGLFDPDSGGLGDELMSSCTPQDFHLLISSLFYQTVLAFSTDRLTEDSLKSGVEYLVDTFLLPSLVMALTFLANHLRTSRAAEPKAVIRILQLILLTKQGSNEAQTMLSAVITIVAKPLEHALRSHQRHDPKNQDIEPLLKAIRDNTQVPPRTAGADSKELEAWTGTANGGLAASVRHTIQGLIQWSLHPGLNVMPTSYTHRQMIAALKMLGPRQLLRLILDEVKQSYSEAGSASYAYDIAMALVCAPDVTNQPPAPPPALMNDPNQQASSIQKRVALRQMLRWEAEDCKKIQKVDPALAEHIVRLHRKVEAQMHIVIQPAPAMMQTDLSLGLDENAAASLDDALAAAQGDVMVANDTGMDLDLGPDPSGMGLDMGGADGGLGLGDDDIFGSLGPVGGGADLLDGWDTML
Length1054
PositionTail
OrganismPestalotiopsis fici (strain W106-1 / CGMCC3.15140)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Xylariomycetidae> Xylariales> Sporocadaceae> Pestalotiopsis.
Aromaticity0.07
Grand average of hydropathy-0.071
Instability index41.45
Isoelectric point4.92
Molecular weight115383.48
Publications
PubMed=25623211

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33502
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.65|      26|     370|     631|     665|       1
---------------------------------------------------------------------------
  567-  617 (30.48/19.47)	LDNWrydeEQGEYQPvyeefgsilllvlafvhrynlDIADLGTRASDSFTA
  640-  665 (51.17/24.40)	LGGW....IQGLFDP.....................DSGGLGDELMSSCTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      94.03|      18|      21|     994|    1011|       2
---------------------------------------------------------------------------
  994- 1011 (34.62/17.13)	GDVMVANDTGMDLDLGPD
 1016- 1031 (30.82/14.50)	GLDMGGADGG..LGLGDD
 1038- 1051 (28.59/12.96)	GPV....GGGADLLDGWD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.97|      18|      22|     302|     322|       3
---------------------------------------------------------------------------
  304-  322 (27.47/26.32)	AVSELPVMNTrAGLYIYLN
  324-  341 (32.50/17.55)	ALVGRPLIDD.AFLYGYLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     123.53|      33|     363|     436|     474|       5
---------------------------------------------------------------------------
  436-  474 (49.93/50.87)	NNTFTDSVRQefcwacCLHGLIPES...AIEVLLGEITYQSL
  487-  502 (19.27/ 7.95)	NECMSDSER........IQGLVNE..................
  813-  848 (54.34/36.52)	NGGLAASVRH......TIQGLIQWSlhpGLNVMPTSYTHRQM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.25|      28|     537|     215|     242|       6
---------------------------------------------------------------------------
  215-  242 (48.38/31.74)	MMLL...GVCENQTVLRALSGPSAKEARKAL
  737-  767 (40.87/25.71)	LILLtkqGSNEAQTMLSAVITIVAKPLEHAL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33502 with Med5 domain of Kingdom Fungi
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