<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33497

Description Uncharacterized protein
SequenceMTSRPPLAVQQRQPQRSISGSGLSQRPAHQRSLSQQYLPPSPIRKSDSFGDVSADVGAYGARRGGSKLKLELSNDGITHAGFSESPQNLDPLSANKAFTPSRMMPLGDASPLGDFSAPQSQCQTADNDSIPLPMPPRRARFVAPASNPGKPQAPPPAPVKKDAKPKPFVLEIPPDAPRYSNMGKGEPSDLGYADFNPWTGNGPEDRFSDQGIRLGNNYDKPPAQPQSEQASAKATIFPALKHKSGLHTLSTLFTGIMNQRRHSGQITSASTFKPPPRVTLTDTKRELWLKDLANPAISLRRLSRTIPHGIRGRVLLDQCLSKKVPTDRAVWLAKCVGANEIRAFKRKGVNGQFVMGGETKWIRDWTVHIEQFVESVCSAFGEDDWKIKVTYAIRLATHLYYEYLMERDHYMDWLVSSLENSNQARLPMWLLTIRIYWQDLLRSRKIGRRFVTAVLSHYAAIYNHPDRDILLPLTTQLQSLLELLLLASPDSFIHPSTWNRYRGAVLPLLQTGHEPQKSAAESIDRRVERLTSTNIKSRPAVRSTAVKLLDITLRKPYSPDLASHLWKLSEDKNGLIRILLEWCMSLYRPGIAKLFVTTNILRSWSTLDVDMTGAILDFMDQDPLEESSRRHMVYHLVSELVRSDHFSVPRYLQWLIARGGLIDPAETLPEAPCLTRLLVELPTHSLKDTIRNLRATILRKGGFSASFEADDIASAIVCIRQSFGLPPERNDLMQAKKPISMKKIAKRLTLSSRALQSEVGNWLCNGLVAGFAQNTQTGKESVGLSSFQFDSIRMLLEATQDFAMLEGSLRLLLPSCCNADLLASFADTINLHCQVFSAIGSAKSLFDSLLERLKAINEMQGIGARPLLAALARLAPRLPGLTDIAAHLQHDLLRMDRSNAVDASSPLSDNMAMQLQDDETELNEQIEKLASFTNADKSTMERLFRTIINRLQNCWNQANEKRQRPYCTLLTRLRVFDTQHFDNLMRDWVQHIRKLSHRPSMPQIFPLLLSFGCLSVPTLFATANRNGMQTGNAVGFASIYVQEVLQLLVMKLIPNHTMTAEDCYRLRIIQEQTKADRVKEMMLLIRCALAEYSASRGLQPPIPQPLDDENTRNQFLELLRSLVLVDPQAASQTLSPKSPDPKLCSLIENMTTNLLVPEGGGQKTFEQVLELANEFTLPFCQVKLSMNMATEDSSGDGGDRLQSQLALLSKALDNAIDANNIMWTGMLSSMSPEITQHMRTRAEARFIDLMPSSKGAGAEDMDSKAVGMSENLLAVIDMIVRGTPGPKAAPISSTVADKIADQWEIISSSSADLAPLRVTTIKHWLPLLLSYLNLVVPGATDASKPANETRARVLLVLAGLVQELERIRELELSQRTYDIALLLADNLADDARVQCVRAVKDATSDRRIHYLFSYWPNPSDSLMLAHKEKPPPGMGINERRAMALGIGMGMLPERLTPFIMRRWEILSEPTPNVGENDTSLSLHLFDARKI
Length1490
PositionKinase
OrganismPestalotiopsis fici (strain W106-1 / CGMCC3.15140)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Xylariomycetidae> Xylariales> Sporocadaceae> Pestalotiopsis.
Aromaticity0.06
Grand average of hydropathy-0.274
Instability index46.12
Isoelectric point8.85
Molecular weight166138.13
Publications
PubMed=25623211

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33497
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.33|      30|      98|     845|     874|       1
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  845-  874 (48.77/33.74)	LFDSLLERLKAI.NEMQGIGARPLLAALARL
  943-  973 (49.56/34.42)	LFRTIINRLQNCwNQANEKRQRPYCTLLTRL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     157.64|      50|      99|     560|     615|       2
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  560-  615 (78.58/54.27)	DLASHLwklsEDKNGLIRILLEWCMSLYRPGIAKLFVTtnILR....SWSTLDVDMTGAI
  663-  716 (79.06/40.98)	DPAETL....PEAPCLTRLLVELPTHSLKDTIRNLRAT..ILRkggfSASFEADDIASAI
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     185.36|      67|      92|    1291|    1363|       3
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 1291- 1321 (30.24/12.02)	..............................................................ISST.VADKIADQWEI..ISSSSADLAPLRVTTI
 1322- 1411 (83.73/67.41)	KHWlP.....LLLSYLNLVVPGAtdaskPANETRARVLLVLAGLVQElerirelelsqrtydIALL.LADNLADDARVqcVRAVKDATSDRRIHYL
 1413- 1467 (71.38/43.77)	SYW.PnpsdsLMLAHKEKPPPGM.....GINERRAMALGIGMGMLPE...................rLTPFIMRRWEI..LS..............
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.23|      17|      17|     154|     170|       4
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  154-  170 (32.94/20.01)	PPPAPVKKD.AKPKPFVL
  173-  190 (27.29/15.09)	PPDAPRYSNmGKGEPSDL
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---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.73|      15|      17|     791|     805|       5
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  791-  805 (25.19/13.00)	SIRMLLEATQDFAML
  808-  822 (26.54/14.09)	SLRLLLPSCCNADLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     240.12|      78|     723|     476|     559|       8
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  476-  559 (116.81/98.37)	QLQSLLELLLLASpDSFIHPST..WNRYRGAVLPLLqTGHEPQKSAAESIDrrveRLTSTNIKSRPAVRSTAVKL.......LDITLRKPYSP
 1200- 1286 (123.32/83.93)	RLQSQLALLSKAL.DNAIDANNimWTGMLSSMSPEI.TQHMRTRAEARFID....LMPSSKGAGAEDMDSKAVGMsenllavIDMIVRGTPGP
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---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     129.31|      32|      92|      14|      45|       9
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   14-   45 (56.62/30.17)	PQRSISGSGLSQRPAHQ.RSLS.QQYLP.PSPIRK
   77-  101 (24.87/ 8.87)	....ITHAGFSESPQNL.DPLSaNKAFT.PS....
  105-  138 (47.81/24.26)	PLGDASPLGDFSAPQSQcQTAD.NDSIPlPMPPRR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.85|      14|      95|     196|     213|      11
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  196-  210 (24.09/20.85)	NPWtGNGPEDRFSDQ
  216-  229 (26.76/ 9.45)	NNY.DKPPAQPQSEQ
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33497 with Med12 domain of Kingdom Fungi
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