<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33495

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDPAEYETNVLVINNISAVAYAFYEPESPPSNFYVSGAIEFEGALRSDGHLVYVDAARHGLWCFRLQKKDDPPGSPSFAKTFDCQGLNFLLVEDGLFEPASLLKSRGYGASAINTPSSSSSSASNPLDAGLRGVQAAAFPGSLNDQEVKMSVQETRGTATTTVRDAYQHFISAVLSALSSTLCNTSGALPLNSRTLLLPQRIQEESGMSIPILTSLRVYLTTTGSLVVMLHASSVKGLHSLSEYAYPPLQGITVLAAPLGVFATCQAVADSEYSSNNSAMPQSPDTQVSRLRPERESGHWRSICAKLLQARNLPSPISGTQKWLSLQRVRRKPIDQSYDGKRTPMITAAPTSLSWPSNLCFCKGLSRLSISDMPSSSPDGSYDPLANAKTWFNSTTEREELLARRKQEREAAAAQQSSTGSQPQPGAGLSPIALHRPSNAGVPPGAMYPTPPDGVQNAVGFTPSIDGTISSPGHQPITTAVVEIDTTVNMPPETFADAWENPEPKRERGGSSFESENLFGDLGPDMFGDNDITDADFSFFDEQPGGLDMTLDSVDLSGADRLLDMTQDFHTAPVTDVTPRPPVAPPPSAPPAPVFAKPELKHARSSLNEQPRRNTEPDVERQRSMTVKRQASPFTPDTVFKRIRASIDTRSMPQLKSNWSTPQPGSIFDKVEFSPSLSLVNRKYHGNGRFSFSLNRDQASKPYVFEAPPTTGYLRRHGKGRRALKDPPANVGELFARMTKGPGISSQHPSPSKLDDPASDADEMSVVSDQDDSSYDSDEPSSPGKTGSVRRRRLDDDEQSLATSFRELEYPDAASPHSSVDLPKFSKSDVDLPLARYFADAEPSSSQLMIPDNDFVIAAQLLTDQACTSTLGIATDPTVSLQSKLSRWRELLATTNLVMQELRSALPSWFVDLDEQLFKPFLEVQDVPLLGQPSRMQPRPPGAEQLKPSNPFQIPPPRFEMRRYDSKLSVLPSAVTFWESLGLGPSNGPKNIHSVCIYPDAEGLADDVDGFLDKMQGSYESLRLGSFSRMSASPDFPGGLFPHELEASGQDFNVTGSILSASLLNGLTKLSDVLSHLPVKETNVVVFFVYSTSIPASPAECCYAFHQLFERYKKLLLSSRTPVENDLVLQLVPMDFLASTNSMCSPSPHDYARLAVETYDRCTMFGGAMPAPAIVLEQTIPRMIDFKLSTTPSASLLHENTCLHIAYAQSVDERWVTAAWTDNRGSLQMTASYCLGRKGKTIATPFVDVGREIWESTHEMISTRKVSWRIIITKCGMMDQSEIDLWSGLAQTESRATVTLTLITVDTDPSLQLLPPEVKVANNATGVFYTTPVSTPQPSMVSPEQSGNPPTPSLRDATSAPTPGGPGDATAESDAEATLTDVTDHTWGSILAHRLNNSTSLTELSPAIVSGYLLKKGGSRLEDPPTVMEVNIVHNEGNPRAYETLLREMLTYFRGLGTLARARGMTNRETDIRPWHIAAAENGSRALYNLM
Length1491
PositionKinase
OrganismPestalotiopsis fici (strain W106-1 / CGMCC3.15140)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Xylariomycetidae> Xylariales> Sporocadaceae> Pestalotiopsis.
Aromaticity0.07
Grand average of hydropathy-0.372
Instability index53.36
Isoelectric point5.23
Molecular weight162369.44
Publications
PubMed=25623211

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats
>MDP33495
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     156.84|      35|      39|     416|     453|       1
---------------------------------------------------------------------------
  416-  450 (63.93/27.23)	QSSTGSQPQ.PGAGLSPIALHRP.SNAGVPPGAMYPT
  456-  490 (47.37/22.20)	QNAVGFTPSiDGTISSP.G.HQPiTTAVVEIDTTVNM
 1334- 1362 (45.54/18.58)	.....STPQ.PSM.VSPEQSGNP.PTPSLRDATSAPT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.91|      33|      39|     946|     984|       2
---------------------------------------------------------------------------
  948-  983 (58.11/44.00)	PSN.PFQIPP....PRFE..MRRYDSKLSVLPSAvtfWESLGL
  985- 1024 (45.80/24.98)	PSNgPKNIHSvciyPDAEglADDVDGFLDKMQGS...YESLRL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     583.30|     203|     655|      21|     284|       3
---------------------------------------------------------------------------
   21-  284 (282.22/258.62)	YAFYEPESPPSNFYVSGAIEFEGALRsdghlvyvdaaRHGlwcfRLQKKdDPPGS..................PSFAKtFDcqglnfllvedglfEPAsllkSRGYGASAINTPSSSSSSASNPLDAGLRG.VQAAAFPGslNDQEVKMSVQETR....GTATTTVrDAYQHFISAVLSALSSTLCNtsgALPlNSRTLLLP........QRIQEESGMS.IPI...........LTSLRVYLTTTGSLVVMLHASSVKGLHSLSEYAYPP...LQGITVLAAPlgvfatcqavadseyssnnSAM.PQSP
  690-  941 (301.08/164.06)	FSFSLNRDQASKPYVFEAPPTTGYLR...........RHG..kgRRALK.DPPANvgelfarmtkgpgissqhPSPSK.LD..............DPA....SDADEMSVVSDQDDSSYDSDEPSSPGKTGsVRRRRLDD..DEQSLATSFRELEypdaASPHSSV.DLPKFSKSDVDLPLARYFAD...AEP.SSSQLMIPdndfviaaQLLTDQACTStLGIatdptvslqskLSRWRELLATTNLVMQELRSALPSWFVDLDEQLFKPfleVQDVPLLGQP...................SRMqPRPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.64|      21|      41|     324|     348|       4
---------------------------------------------------------------------------
  324-  348 (32.33/22.98)	LSLQRVRRKPIDQSYDgkrtPMITA
  368-  388 (38.31/18.29)	LSISDMPSSSPDGSYD....PLANA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.46|      21|      41|     513|     534|       5
---------------------------------------------------------------------------
  513-  534 (35.06/26.22)	FESENLFG.....DLGPDmFGDNDITD
  551-  576 (32.40/18.60)	LDSVDLSGadrllDMTQD.FHTAPVTD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     109.05|      33|      41|     601|     633|       6
---------------------------------------------------------------------------
  601-  633 (55.98/38.17)	KHARSSLNEQ..PRRNTEPDVERQRSMTVKRQASP
  641-  675 (53.07/35.71)	KRIRASIDTRsmPQLKSNWSTPQPGSIFDKVEFSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     115.57|      39|      45|    1069|    1112|       7
---------------------------------------------------------------------------
 1069- 1112 (58.78/50.26)	KLsdVLS.HLPVkETNVVVF.....FVYSTSIPASPAECCYAfhQL.FERY
 1114- 1159 (56.79/32.00)	KL..LLSsRTPV.ENDLVLQlvpmdFLASTNSMCSPSPHDYA..RLaVETY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.42|      28|      39|    1188|    1215|      13
---------------------------------------------------------------------------
 1188- 1215 (48.24/29.21)	LSTTPSASLLHENTCLHIAYAQSVDERW
 1227- 1254 (49.18/29.91)	LQMTASYCLGRKGKTIATPFVDVGREIW
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33495 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) NDITDADFSFFDEQPGGLDMTLDSVDLSGADRLLDMTQDFHTAPVTDVTPRPPVAPPPSAPPAPVFAKPELKHARSSLNEQPRRNTEPDVERQRSMTVKRQASPFT
2) NRDQASKPYVFEAPPTTGYLRRHGKGRRALKDPPANVGELFARMTKGPGISSQHPSPSKLDDPASDADEMSVVSDQDDSSYDSDEPSSPGKTGSVRRRRLDDDEQSLATSFRELEY
3) TEREELLARRKQEREAAAAQQSSTGSQPQPGAGLSPIALHRPSNAGVPPGAMYPTPPDGVQNAVGFTPSIDGTISSPGHQPITTAVVEIDTTVNMPPETFADAWENPEPKRERGGSSFESENLFGDLGPDMF
4) TGVFYTTPVSTPQPSMVSPEQSGNPPTPSLRDATSAPTPGGPGDATAESDAEATLTDVT
530
695
396
1325
635
810
527
1383










Molecular Recognition Features






MoRF SequenceStartStop




1) ARYFA
2) DITDADFSFFDE
3) TVFKRIRA
4) YLRRHGKG
835
531
638
713
839
542
645
720