<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33492

Description Uncharacterized protein
SequenceMTSVPSADQRPPLRLHDPASFSATNNPFGLSTTQGRSQPAGIFDVDDRATKRRKVDEPADAEGDPAQPLPSVPEPPKAPQPKYRTTQDLRLLSAVLTADGFPDNIKSDAKDLPLMPSHPWRDRPQKKSPEEPKPTHRSRPKRQVPCTPDTLVIPDSGPRLVNGNPAGYFPWGTRKHAEDNLSEINVKQGYYDRPPNPPEKELNTARVPLYNAFKHRGGVESLSTLFTIVLEAKAKHGVLTSASSFKPPPRVTLAEPRKKSWIADLADPNVPLRKLSRTIPQGIRGHSLLEQCLQNSVPLSRTIWFVKCVGANEIRTLKRKGTSQAAAVGGERNWLREWTLNVQQFLEAVLAQSGQPSWKPNLQYALRLTTRLYLENLVDRDHYLDWLVNTFAAVGNEKLPFWLMLSHVFKQDVAKFRKRGRRLAASLTKRYLLLKDSSNAMVQAVAQKLKDAIRGFVLHRPQLFLIPDIWPEVKSALETCLQKDSALETRLLQRLNFVNERCMGSNKQQYLARPVPRDDIIGILDATFAPFDVTTLSQQLLTVTSDQQLLILAAIEWATTKYRCGQARIYLVSRLLRKWQKMGINTDEAIIAFVAKCHGSPELFDSAALKHLAAELSRSRSFPSSKYMQWLSVRGLPWPNSVTTSETQSRTGAEEVLIRQVCSDETLLLAELLFSDVESHHLNLRNALLGRAGFDAELERKTTQFVQTRVRNLLGRVENDEHASVCSATDFEHLLSGWNWRVRSAVSHGLRGYVVAQVKRQATTRQGSTPLQKESGFTTPSFDFVRSCLEALGDDAVLADVVGLCSAVNDEQLQAALVDTVIRHAATFSAIGALEPLQTRFCQNYMSLRTVNPTMPLFATALLELCTTYPTKLGSIKLLQLDLIRGDRGRAIAACSPFSDGVAESLQHAEASFIDEFEAVLQSEPSMSEQAMAKMFALLVERMEKQAHGSDSEFLFTCCQLMARLRLCRRTQGDQLLKTWLVKLLSMNPTGFAQTLVSNLICVGAVSVDALVDAFAGHRMAPYILQHMFPTALPNRPYSVVTKWADFGHRKPSQLLNLTSQLPPAAAGGFDIQELCARIVVKSDVVLDQAANTRLKQTLDGFLGKGESGDASSSLEAMDSFSLPFVRLYFQLSATSTSQTDESGLAESIVSVAASGSIENIAKLLQSAGPELSGQVRRLLEDNIIEMLPSPSQGKLLDVSLDPERIERLQVAVDQAFLLCQPSSTSSSKNATQLIEKLQQFLKFLGPSGSSQNQAASPAASQKPAVTSPSTPSIAAMPSLSSHLVPSSPMDFSSRALPHTIIDYFRVLLNLLCLQRPAPPAASDAKAAPSKTNQEYVRVLSYLAFIATHPAFLLPSTTFPASPALQQRAREVVDFAYDVMATFVDDLSEESRILCSRILKDRLTEGATGPAYAAVKESQARLRWLFGSINAMGSDMPSAEEMGKGLLVKRSVPGGGADGKGAAETVKDWKPRIWEVLESQGRGDGEVSVGLGLFGARRP
Length1499
PositionKinase
OrganismCyphellophora europaea CBS 101466
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Chaetothyriomycetidae> Chaetothyriales> Cyphellophoraceae> Cyphellophora.
Aromaticity0.07
Grand average of hydropathy-0.237
Instability index49.57
Isoelectric point8.87
Molecular weight165078.81
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33492
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     123.65|      34|      53|      67|     103|       1
---------------------------------------------------------------------------
   67-  103 (55.80/35.17)	QPLPSVPEPPKAPQPKYRTTQDLRLLSAVLTadgFPD
  110-  127 (23.73/ 6.85)	KDLPLMPSHPWRDRPQKK...................
  129-  155 (44.13/20.69)	......PEEPK.PTHRSRPKRQVPCTPDTLV...IPD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.03|      21|     138|    1211|    1233|       2
---------------------------------------------------------------------------
 1211- 1233 (29.83/20.87)	VAVDQAFLLcqPSSTSSSKNATQ
 1346- 1366 (36.20/18.74)	IATHPAFLL..PSTTFPASPALQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.92|      20|     138|     373|     392|       3
---------------------------------------------------------------------------
  373-  392 (38.35/25.39)	YLENLVDRDHYLDWLVNTFA
  510-  529 (36.57/23.87)	YLARPVPRDDIIGILDATFA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.14|      14|     138|     451|     464|       4
---------------------------------------------------------------------------
  451-  464 (27.68/18.77)	DAIRGFV..LH.RPQLF
  588-  604 (18.46/ 9.87)	EAIIAFVakCHgSPELF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.76|      17|     138|     848|     866|       5
---------------------------------------------------------------------------
  848-  866 (26.90/17.95)	LRTVNPTMplFATALLE..LC
  984- 1002 (25.86/11.06)	LLSMNPTG..FAQTLVSnlIC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     128.11|      40|     261|    1022|    1066|      10
---------------------------------------------------------------------------
 1022- 1066 (65.03/44.74)	PYILQHMFPTA...LPNR..PYSVVtkwaDFgHRKPSQLLNLTSQLPPAA
 1278- 1322 (63.08/31.12)	PSLSSHLVPSSpmdFSSRalPHTII....DY.FRVLLNLLCLQRPAPPAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.63|      29|     261|     880|     926|      11
---------------------------------------------------------------------------
  782-  819 (39.85/12.26)	FDFVRsclealGDDavlADVVGLCSAVND...EQLQ...AALVD
  881-  915 (41.78/40.03)	LDLIR......GDR...GRAIAACSPFSDgvaESLQhaeASFID
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33492 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MTSVPSADQRPPLRLHDPASFSATNNPFGLSTTQGRSQPAGIFDVDDRATKRRKVDEPADAEGDPAQPLPSVPEPPKAPQPKYRTTQDLRLLSAVLTADGFPDNIKSDAKDLPLMPSHPWRDRPQKKSPEEPKPTHRSRPKRQVPCTPDTLVIPDSGPR
1
159










Molecular Recognition Features






MoRF SequenceStartStop




1) AGIFDVDDRATKRRKVDEPAD
2) TQDLRLLSAVL
40
86
60
96