<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33489

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMENEFNADPFFNDGPLQQINEGSLQQIDQIDPAGVGIDALNNVPLPVNPLIVQRILNLHQGGSSTRLCWSRQGHIANISEDGSSIDLHCLVFDRTRRTWVVGAKRTEHVGLGELASLAWSPMATDIAVVDTRGRLSILRPTGTAANRLSEVRSGTIDDIQDLGQAIGMGWLSQDRAERPKQVVQFTSKQEGGDKWVHNLVKAMPMQPLYQRAIVVINRQGTMALVYEKPDSTFAKTTSQLAPKTDTIFTHAAFSPTTEGKLMVALHAHDGTLSAYHVSIDFSPMRQDPDALPLLNSQLAASRFPRIGNTSIDGQMYDSDSQCLTHLGIIPTSEIEKTAPQPPTVYGIYANINKNMGATDGGFISSGTIRRWTLSSVHQTLLPKFNHLPDKATNSAPVFTTSVQLLPEKEEQGITNAGVLDNGQGLFITTLDGRTDFLATEDLSSLSFAASENTTSSLAQSGFNFPLLSNQTSISLSPNVCCSAVLSPASTVSLVPADFHPPTAESSQSLDPTSSSADAAAAVIVLSFARSCWTNSNIDDLLSMVLHTFSASMATPLIVSLYHTLFREGEFMHEKDSRSELEKVVQKPVLTKVFSFHYGVAFLSIKDVPPSSPIPLSAQWVWVAANLRFVAQLLYISIREVQNPSAEPSSELVEMVCGNIKWTLDLVRYIAASIFEVSDRETNPEFFDKPQGGHVVDGSQGLVALLLNCHWSRQFFIAIVRAMRVLCKLPEPRSAQQTEIIRTIMQWSQGKGLSLIAVEALLDPRWSGWADNELEGDLAKISSRQIRMMATGVVEGGFQGTVRRVLGKLFNVKGGMRDKGAVDRLKLWSHKVDLGWVLLDDEWEGARPEGRKKRVFDVHKKKVITKGKREIISGESGEEMIKRCVRCGRHNEDVNGMGKEFPRHVAGLMMRCVCDGPWIVEPWAKAIT
Length927
PositionTail
OrganismCyphellophora europaea CBS 101466
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Chaetothyriomycetidae> Chaetothyriales> Cyphellophoraceae> Cyphellophora.
Aromaticity0.07
Grand average of hydropathy-0.162
Instability index42.10
Isoelectric point6.18
Molecular weight101844.89
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33489
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     248.00|      64|      79|      34|      97|       1
---------------------------------------------------------------------------
   34-   89 (89.13/52.71)	....................GVG.IDA.LNNV..PLPVNPLIVQ...RILNLHQGGSST.RLCWSRQGHIANISEDGS..SIDLHC
   90-  170 (80.25/46.71)	LVFDRTRRtwvvgakrtehvGLGeLAS.LAWS..PMATDIAVVDtrgRLSILRPTGTAAnRLSEVRSGTIDDIQDLGQ..AIGMGW
  171-  220 (27.86/11.29)	LSQDRAER..pkqvvqftskQEG.GDKwVHNLvkAMPMQPLYQR...AIVVINRQG..............................
  282-  322 (50.76/26.77)	...............................S..PMRQD...PD...ALPLLN.....S.QLAASRFPRIGNTSIDGQmyDSDSQC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     155.19|      47|      79|     715|     767|       2
---------------------------------------------------------------------------
  715-  767 (74.38/62.30)	FIAIVRamRVLCKLPEPRSA.QQTEIIRTIMQWSQGKGLSLIaveaLLDPRWSG
  797-  844 (80.81/52.10)	FQGTVR..RVLGKLFNVKGGmRDKGAVDRLKLWSHKVDLGWV....LLDDEWEG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.77|      15|      15|     443|     457|       3
---------------------------------------------------------------------------
  443-  457 (24.24/14.56)	SSLSFA.ASENTTSSL
  460-  475 (22.53/13.02)	SGFNFPlLSNQTSISL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.27|      14|      15|     535|     548|       7
---------------------------------------------------------------------------
  535-  548 (23.61/14.96)	SNIDDLLSMVLHTF
  551-  564 (23.65/15.00)	SMATPLIVSLYHTL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33489 with Med16 domain of Kingdom Fungi
Unable to open file!