<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33483

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMSATQYPPKIPLSPSSPPETGVKRRRASETSPKLPPSPKYMSVATKSYVSHGTHTSHMDEAASRSSPRSPSSASSYTRPSTQRNSQPYSTPSSSHSEHHTSNMMERDEHRDKRQRIGEAMDLDESMLPTNHERRSKKEDEGTSPRLGDIEMQDSAGDPDLDELDKDIGEPYLSCRSRVEPQKPDVQTHLLSIYGLGSLQRSVARQDPFTQEKINKLRKSYEGQIKDFQLAGRNKAVKLKQEKPNEPSMRASIGSFTSETRGTYLQNTEEWEAANPKREIKVTDDFRSKLRKAMQMQPGRVRNEAKWDDVLGHEKKTAAPLAMASAQAAAQRPNGLMRPAPQSAAELKRQTRGKKRSYGDDSFIGYGEGYSEPEDASPDGEYGSDDGNRKKRRKVGF
Length396
PositionHead
OrganismCyphellophora europaea CBS 101466
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Chaetothyriomycetidae> Chaetothyriales> Cyphellophoraceae> Cyphellophora.
Aromaticity0.05
Grand average of hydropathy-1.229
Instability index63.40
Isoelectric point9.30
Molecular weight44339.62
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364151

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33483
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     132.08|      39|      56|       8|      61|       1
---------------------------------------------------------------------------
    8-   60 (57.67/46.81)	PKIPLSPSSPPETGVKRrrasETSPKLPPSPkymsvatkSYVSHgtHTSHMDE
   67-  105 (74.41/30.00)	PRSPSSASSYTRPSTQR....NSQPYSTPSS........SHSEH..HTSNMME
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      61.59|      18|      55|     226|     243|       2
---------------------------------------------------------------------------
  172-  183 (15.13/ 6.69)	...........LSCRS.......RVEPQKP
  184-  213 (16.21/ 7.67)	DVQthllsiygLGSLQRSVarqdPFTQEKI
  226-  243 (30.25/20.48)	DFQ........LAGRNKAV....KLKQEKP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      31.75|      13|      23|     108|     124|       3
---------------------------------------------------------------------------
  115-  135 (10.42/13.63)	RIGEaMDLDEsmlptnhERRS
  145-  157 (21.32/ 8.60)	RLGD.IEMQD.......SAGD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33483 with Med19 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MSATQYPPKIPLSPSSPPETGVKRRRASETSPKLPPSPKYMSVATKSYVSHGTHTSHMDEAASRSSPRSPSSASSYTRPSTQRNSQPYSTPSSSHSEHHTSNMMERDEHRDKRQRIGEAMDLDESMLPTNHERRSKKEDEGTSPRLGDIEMQDSAGDPDLDELDKDIGEPYLSCRSRVEPQKPDVQTHLLS
2) YLQNTEEWEAANPKREIKVTDDFRSKLRKAMQMQPGRVRNEAKWDDVLGHEKKTAAPLAMASAQAAAQRPNGLMRPAPQSAAELKRQTRGKKRSYGDDSFIGYGEGYSEPEDASPDGEYGSDDGNRKKRRKVGF
1
263
191
396










Molecular Recognition Features






MoRF SequenceStartStop




1) DGEYGSDD
2) ETGVKRRRASETSPKLP
3) HLLSIY
4) MSATQYPPKIPLS
5) NRKKRRKVGF
6) PKYMSVATKSYVSH
7) YGDDSFIGYGEGYSEPE
378
19
188
1
387
38
357
385
35
193
13
396
51
373