<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33478

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTAVAEFPSNCSTNTIVLQDFGEVAYIVCTVSIPPQNHNAPPDPSPESNLARLKHTEKQFHQASILASIDNDALQLFTFYKKIDVLKDQRTILTKFGQILRSNSCTISYKAAARAPDLLKPENGRLYRLFITAVLANIEITVTDGRRLTPLGQRYHAVEVLNAPRSLIENDLEEWALMRTDLQMVHTGQIILTVSEQRHLTPLTVSARGLQQPIDYGKPWRAMPVVLAPTGQLAVYRNGWIGRAEDGHGHPKALSKHLLASLHIWQGLFEKWSKLEPYVDTQIDDLWAELSIPVQEQPVTEPPTSPNAKKHEIKSSMSFKTLFWPAKWCFAFDLSRGFSDDGSGTEAEYDPVQFILEWFETLGNGDYGLSHSTNRTASADNDDASIFPEDTAFENAETFQPFGPPVFPASQTVYPTPPDVVMTHATPAMSSVDGMAATPATLSRIAAEASTLRQDQAMEVDSGIAVGVGSGLYDEDLFEDMPDEAFGQNAAGDEPNWDFFDKPTLEAEAADIELADAMDVDPLTQPSDGAGDEEQNNAAGNVSAPQVSKAETLASQQHEEMAEQVPSSVSPSEDAPKMGRASADPLITEEFPAPESGDTRPRRPSVFDGVHRRTTSPQRDQRYTATGSFHFNARAAPTKMAASPPSLDQWIKRSPSPSVSSDSDLSGYETPIYADSPLEYRIPTPGQLPDESTSMAAEGQNLKIDTEALEQEAHLVFELVSVQHTRSTLDDAVVFAKPAGLGSQFDKPNVRNGFAHEVVHQITQTCLLHDVYGVSSLTVDGASRHDVSLTMGNLADGTGFSNVAHLCGIVPPTSGKKPIGRTTRLPEPEVTMKRLDKQITARPSILPFWDTLGLQPAPKSKDVTAFCLHPHGSGMADSCLDFLDRISDAYVSCNLGQHQAGSIAGVSSDGLLEADPNDQGMFLGPVRRLGEALAKPTQKGGTLVIYLIANSRHDMAYVYCSVAAYAIRRHVEQGWAKRSEQLNLVFQVVPPDFVASSQEVVVPAQSAYNSVALGVYSRIPPFDIETSLGICEYPLVLPEGRDGVNFGLEAGVISPLSKDGACLHVGYSWSDDRRWLVAAWTDARGFLSFVMPYQIKSHILGPARSIDEVVKDMWAISHELMARQRNRWKLVVSRAGTFEAPEINAWMSVANSRAESAKSKCSLSLLTVELNPTLRIFPQAEHGKSAQNAYGTPASTPQGGVTSPEQVVAATPTPGGTSTLNAPTPPEQGFDPNADNDLSIVDPGEESWAVILPYGVNQSKDILEIRPAVASGYLVKRNGIREEDGLTMLGVHMIWPTPNPSTTPPGQREDELEDLVNDFRGLVTLAAARGCIDKATSCVPWHIHTSVTGATTLGKLI
Length1357
PositionKinase
OrganismCyphellophora europaea CBS 101466
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Chaetothyriomycetidae> Chaetothyriales> Cyphellophoraceae> Cyphellophora.
Aromaticity0.07
Grand average of hydropathy-0.304
Instability index47.52
Isoelectric point4.96
Molecular weight147559.81
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33478
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     609.84|     219|     529|     494|     765|       1
---------------------------------------------------------------------------
  387-  493 (82.76/27.72)	..............................................................................F.........................PedtAFENAETfQPFGPPVFPASQTVYPT...........................................................................................................................................................................................................................................................................................................................PP.DVVMThAT.....PAMSSVDGMAATPATLsriaaeastlrqDQAMEVDSGIAVGVGSGL.......YDEDLFED............MPDEAFGQNAAGD...................................................................
  513-  764 (341.42/267.54)	ELADAMDVDPLTqpSDGAGDEEQNNAAGNVsapqvskAETLASQQHEEMAEQVPssvsPSEDAPKMGRASADPliTEEF.........................P...APESGDT.RPRRPSVFDGVHRRTTS...........................................................................................................................................................................................................................................................................................................................PQRDQRYT.ATGSFHFNARAAPTKMAASPPSL............DQWIKRSPSPSVSSDSDL.....SGYETPIYADSPLeyRIPTPGqLPDESTSMAAEGQnlkidtealeQEAHLVFELVSVQHTRSTLDdavvfAKPA.GLGSQFDKPNVR..NGFAHEVVHQITQ
  767-  862 (47.94/13.61)	LLHDVYGVSSLT..VDGASRHDVSLTMGNL.......ADGTGFSNVAHLCGIVP....PTSGKKPIGRTTRLP..EPEVtmkrldkqitarpsilpfwdtlglqP...APKSKD.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
 1178- 1296 (137.73/62.96)	.....................................................................................................................................vtafclhphgsgmadscldfldrisdayvscnlgqhqagsiagvssdglleadpndqgmflgpvrrlgealakptqkggtlviyliansrhdmayvycsvaayairrhveqgwakrseqlnlvfqvvppdfvassqevvvpaqsaynsvalgvysrippfdietslgiceyplvlpegrdgvnfgleagvisplskdgaclhvgyswsddrrwlvaawtdargflsfvmpyqikshilgparsidevvkdmwaishelmarqrnrwklvvsragtfeapeinawmsvansraesakskcslslltvelnptlrifPQAEHGKS.AQNAYGTPA.STPQGGVTSP...............EQVVAATPTPGGTSTLNAptppeQGFD.P.NADNDL..SIVDPG........................EESWAVILPYGVNQSKDILE.....IRPAvASGYLVKRNGIReeDGLTMLGVHMIWP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     140.55|      40|      51|     112|     151|       2
---------------------------------------------------------------------------
   70-  121 (45.44/26.64)	DNDAL.QLF..TF.YKKIDV.LKDQRTiLTKFgqilrsnsctisykaAARA...PDLLKP
  122-  172 (43.84/25.44)	ENGRLYRLFITAV.LANIEITVTDGRR.LTPL....gqryhavevlnAPRSlieNDL...
  173-  229 (51.27/31.05)	EEWALMRTDLQMVhTGQIILTVSEQRH.LTPLtvsarglqqpidygkPWRA..mPVVLAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.58|      21|      57|     251|     272|       3
---------------------------------------------------------------------------
  251-  272 (36.20/32.11)	PKAlSKHLLASLHIWQGLF..EKW
  306-  328 (34.38/24.70)	PNA.KKHEIKSSMSFKTLFwpAKW
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33478 with Med13 domain of Kingdom Fungi
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