<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33477

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMNGEGPQLNGQHLPNGTQSIKPPPPPEAKFSKSVDNAALRPAGPGLSKTQMNGVSSGHLPNGAATHLRGYSPPPDEPLQLVDQEHYLPVATLVSRSAQKCWNDLYELVDQLSAIEVPAQPVNAQPGSGYVPAPNNTTKANLDKKDRILNFANDQKANLIKLMVLLQWSRNVKDVSKTISLNFWLHRQREQYNLACYEFYMLKTEATEWQLPNPDIQTAGEILSLGKKASLPHLGYRPAAKLSKKQIISTLRRLNNLLTARLTLEDEIPPPLRNYRVHDGRATFIVSDEFEVDLSVLEEDPTTPFRMVDLRFLFSPRPSISDELRAELERLTDTELSKDGLSGCYDFLHDLTLSNKLAEYHKQALNLSHKQWAGHVRVEFLHRNLVVQYWTERPMPKSWVEIGIYSGRDARDVTQVSSTLGVRWYREGKRVEDFSLVIRPSTISLTSILSQLIAQHVCFMLSSIYDKLLPNILFSSGALALEESTSNVQPEECSLQIQTTKDFSITISINAVTGLVVVGPASEKSNRLQVELNRSKSLVEDFVSKFLNFRCAIAEAHILRVVRNTSWQALLAFKPTLTDLRTLFGLSTTRANFFRHPFWSQEYVLVVAYKPTGDAISIVQMPRASTALASSRIVHTQTLKFSDDLSAAYFESLAEYASGVVVLDNISQQFKHAAYRHTLAGIPDFGSKYTLPSLAFQTTSQSQSTSESLLVDDTARIQFVRVDAASQKAKLLVQLKTDAPEEVLHRLRASSSETRFEFTPKDRQIAFQLQIQIGGAGANDIIQDVRRLSDVVSSVQFMETLSNVRLVSTSMRTMVLAYHFNGSTERELQIQFPSGTNPPRVEFVPRDSNPHACLQFSLSQMLQDPRQPFALHLIDMMSLLALVDPMIMCLHELVQSNSSERSSSKVRIHLLVRQPTMFALQYYAADPKGPADVSTMNVNSRLLARFEILPFQHEKSAFILRPALEELKSYQRPSFTSDVMRAKLKEALFQMAETSPDWLRLDTAAAFLADRPKPIFEALHKLMVDIVEHPQKLVAEDAANVQDPKTNQTPIQPPAKASGNNTQKPVPKTPQQNQRQVPNGANQQQQRPRPNNKPAMDTQGKEVITLD
Length1106
PositionTail
OrganismCyphellophora europaea CBS 101466
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Chaetothyriomycetidae> Chaetothyriales> Cyphellophoraceae> Cyphellophora.
Aromaticity0.07
Grand average of hydropathy-0.330
Instability index42.55
Isoelectric point8.35
Molecular weight124064.95
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33477
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.76|      10|     273|     300|     313|       1
---------------------------------------------------------------------------
  300-  313 (15.11/20.37)	PTtpfrMVDLRFLF
  574-  583 (19.65/11.02)	PT....LTDLRTLF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.82|      23|      42|    1027|    1049|       2
---------------------------------------------------------------------------
 1027- 1049 (40.04/22.18)	EHPQKLVAEDAANVQD.PKTNQTP
 1070- 1093 (38.77/21.25)	QQNQRQVPNGANQQQQrPRPNNKP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     134.36|      41|      45|       7|      48|       4
---------------------------------------------------------------------------
    7-   48 (72.12/45.14)	QLNG...QHLPNGTQS.IKP.PPPPEAKFsKSVDNAALRPAGPGLSK
   50-   95 (62.24/34.34)	QMNGvssGHLPNGAAThLRGySPPPDEPL.QLVDQEHYLPVATLVSR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     132.69|      41|     532|     338|     393|       6
---------------------------------------------------------------------------
  338-  393 (64.08/63.55)	DGLSGCydfLHDLTLSNklaeyhkqalnlSHKQWAGHVRVEFLHRN...LVVQYWTERP
  883-  926 (68.61/38.73)	DPMIMC...LHELVQSN............SSERSSSKVRIHLLVRQptmFALQYYAADP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     136.21|      46|     532|     245|     295|       7
---------------------------------------------------------------------------
  245-  295 (69.80/68.79)	QIISTLRRLNNLLTARLTLEdeippPLRNYR.VHDGRATFIVSDEF....EVDLSV
  779-  829 (66.40/50.85)	DIIQDVRRLSDVVSSVQFME.....TLSNVRlVSTSMRTMVLAYHFngstERELQI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33477 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LVAEDAANVQDPKTNQTPIQPPAKASGNNTQKPVPKTPQQNQRQVPNGANQQQQRPRPNNKPAMDTQGKEVITLD
2) MNGEGPQLNGQHLPNGTQSIKPPPPPEAKFSKSVDNAALRPAGPGLSKTQMNGVSSGHLPNGAATHLRGYSPPPDEPLQLVDQE
1032
1
1106
84










Molecular Recognition Features






MoRF SequenceStartStop




NANANA