<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33475

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMAITEWNGLCRQSLILRTTPNDFVKIVQGKQPLDGKTVLKSLLECRQSLYPPSDPLPPRYLEAIVTSHIASLSDLLVVLISRWNTLCRTDPPHAPSYADTATLQELAVLIISSRLVLDHTQIQKCLLLAARWLSALVKAVGQDNNSPASNFVEPLGSFLATLCATNSGIEILSEKEDDKISRVADAVRQGVEATLGLFPSVSGQLMERLGEVQKHIAMFGDGASSDMQALQFQAGVSELQMAASRAGTVALLQSLLYTARTVDDTVVFNFLAGRHDNDFASMFLDLVFASFLVLKQSKNHGLQQSDHYIRNKLPAILSQISTSSFESFSAEQALIDAWPQLELGTDLLACGQKFVHVCSLHHLLTDEASSNLINDEDLVGSLTKSLLLKDELVSQLTGSPSRAGKLVDEMMNADGNGPSISQALVEVMVAYAHSKETHHLKDLANILLRKPDAINTMALYLRPSYWIAPLCTLLDEWRWDEIHGESQPLYDEFGSILLLILTTKRRLDLTSSELGVKGFVARYLDQEGVEKTVAELSEPSQRHLGDWINALYIAEGLSDDLTTDCSPHDFYTLVPTLIRQSVLAQQTGKLSSEALKGGLEYLLEPFLLPSLVSAMTWAQEHVSIGKALMPIFTKQTGNEIHQTILAMLQSPSNFTFEKLEKTDLQALQQKISAAVTNPATTVSLRYALQVFGAEAVLKCILDVLLQYSGTEDFHFALDLAATLVCVADLRDAVRLKHAELGQLLKKRDTLTAEATVHLYRRVEAYSSVFVVQETNMDIISLPHIDPSDANQEGNQNQEQQMDDIDQVLNESAAMNAMDSGLEGAMDDGMGQGDNMDSFYLQDDNMGLGNLDDLDLDMF
Length858
PositionTail
OrganismCyphellophora europaea CBS 101466
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Chaetothyriomycetidae> Chaetothyriales> Cyphellophoraceae> Cyphellophora.
Aromaticity0.06
Grand average of hydropathy-0.033
Instability index45.14
Isoelectric point4.74
Molecular weight94410.38
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33475
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.27|      18|      18|     390|     407|       1
---------------------------------------------------------------------------
  377-  394 (25.45/12.38)	DLVGSLTKSLLLKDELVS
  395-  412 (30.82/16.32)	QLTGSPSRAGKLVDEMMN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     188.87|      62|     206|     248|     365|       2
---------------------------------------------------------------------------
   21-   90 (95.49/43.48)	NDFVKIVqgkqpLDgkTVLKSLLECRQSL...YPPSDPLP....PRYLEAIVTSHIASLSDLLvVLISRWNTL.CRTD
  277-  346 (93.38/153.13)	NDFASMF.....LD..LVFASFLVLKQSKnhgLQQSDHYIrnklPAILSQISTSSFESFSAEQ.ALIDAWPQLeLGTD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     554.29|     188|     205|     436|     638|       3
---------------------------------------------------------------------------
  434-  636 (285.67/266.63)	SKETHH.....LKDLANILLRKPDAINTMALYLRPSYWIA.PLCTLldEWRWD.EIHGeSQPLYDEFGSILLLILTTKR...RLDLTSSELGVKGFvaryldQEGVEKTVAELSEPSQRHlgDWINA.....LY.IAEGLSDDLTTDCSPHDFYTLvPTLirQSVLAQQTGKLSSEALKGGLEYLL.EPFLLPSLVSAMTWAQEHvSIGKA.LMPIFTKQT
  637-  842 (268.62/204.83)	GNEIHQtilamLQSPSNFTFEKLEKTDLQALQQKISAAVTnPATTV..SLRYAlQVFG.AEAVLKCILDVLLQYSGTEDfhfALDLAATLVCVADL......RDAVRLKHAELGQLLKKR..DTLTAeatvhLYrRVEAYSSVFVVQETNMDIISL.PHI..DPSDANQEGNQNQEQQMDDIDQVLnESAAMNAMDSGLEGAMDD.GMGQGdNMDSFYLQD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     134.96|      42|      44|     133|     174|       4
---------------------------------------------------------------------------
  133-  174 (66.86/47.07)	LSALVKAVGQDNNSPASNFVEPLGSFLATLCATNSGIEILSE
  180-  221 (68.10/48.09)	ISRVADAVRQGVEATLGLFPSVSGQLMERLGEVQKHIAMFGD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33475 with Med5 domain of Kingdom Fungi
Unable to open file!