<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33473
Description |
Mediator of RNA polymerase II transcription subunit 17 |
Sequence | MSTKIRVPVDIPQGDAATSGDLSVRINQIFVQKGPFRNITEQTVALDPDTDEDDSPTDQEDDADNETREERLEVLAKSREELYAEIHRGTLQCNQALDFISLFLSKHSRAAQGTFSDTLRQSMKPGMFDSHILEDARYAPTIRPVAELSKGWRTEGFASASNALTSASERLKKESQRQSSFWQQVADVGQEGWKVCRHPRDRRAMGVHFGMTESAPQFRNQGFAKLYQDSESDVHLARQVAPRRVSVTVSRGGRETGRHSPATTHSEQRSPANRELVEARDSLIDEELFFELGREARLAANQGFITRGEDIEFTIDEQYTVTLSLTPSRAETDPNDFDNDLAQYIGLSIRSLLCQAHHESRIRRAHPPPPISMRPAHLPEYAILRPLVAALKQSIASPAARKHLDDSVIGPLRRAGIDLEFAEAEPQESDLPHQTHSMLTTGLQQSIYTLKLPTGIQHNLKVTSYLGRPIYGTVYEVDDAKYDSMKHFVTVINDLVTRDITAFIAKEIYTEKRRWHIVDAYKGDLALDFEGGGQTPCTLRVGLKGGVLLAKLSNEQPMSWRSTSVDVKSLMDTIRDNMPKD |
Length | 581 |
Position | Head |
Organism | Cyphellophora europaea CBS 101466 |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes>
Chaetothyriomycetidae> Chaetothyriales> Cyphellophoraceae> Cyphellophora.
|
Aromaticity | 0.07 |
Grand average of hydropathy | -0.583 |
Instability index | 53.25 |
Isoelectric point | 5.76 |
Molecular weight | 65176.22 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364140
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP33473
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 133.74| 35| 98| 136| 170| 1
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136- 170 (58.88/40.73) ARYAPTIRPVAELSK.GW.........................RTEGFASASNALTSASER
183- 236 (21.40/ 9.95) .......QQVADVGQeGWkvcrhprdrramgvhfgmtesapqfRNQGFAKLYQDSESDVHL
237- 269 (53.46/36.29) ARQVAPRRVSVTVSR.GG.........................RETG..RHSPATTHSEQR
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 35.24| 10| 37| 462| 471| 2
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462- 471 (18.48/14.50) VTSYLGRPIY
500- 509 (16.76/12.42) ITAFIAKEIY
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