<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33461

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMTIFRGQVPNPAGVYPLNGEDASGTKEPVFPDFRIWKHSPKDDIIMKNHLQKGYYEAAAVPSESHSGRQIFTQLLNRTTPDVSEPGSRWKMGLLSDVMVRALARRREINKIRSKSTYRPPPRVTLTDHKRDLWMRNLADASIPLRQLARAIPHGLRNRFLLEQCLAHRVPVLRALWLVRCVSANEQRQLKRKLPNPAALGKWMVEWTEQVVQFLEQVVAASFAPASRDAWRFRLSYILDLSSNLYLEDLLSRETFLAWIVNYLDRLLRSDQHKLVAVHFQFVRLFWSKLIAVDYISKELGEKLLRAVSTVQQPRLLAEFRLLVQYLFYYNSDAFIIPNSWNALKSTLRAVIDLSYPPVCEQYRLIAYRNESMMIDESAADAYTNFGSKKAVAVMQRLEAVRTLSLKMLCRDTFEDSSDDDAGAADDWKTTLSLLLRWSITTLREQDSGARICAVCSLLRLQVQQLGQVKSKKNRHLKLELEMAIIDFAYQMAETLRLKEPEHGVYSLSRFLLLVTELHALGLFVLSSYLRRLIASGVIYLQDADSSCYVHLLILDALPVEDSNARNILRRLADSTGVALRTAEAPSLQERLATALDSLPATFDLDALWPCDETDPEAEPLDIGSRARLYPWFSARLRQDAVWLQTPDALLFVYRLCDERFRQTAPFLALAVEHADTQPTVPRATLSLLLRLVALHTELLAYCHDGESSLLQRVHGFLAAWAQKDKHGVCTLLLDVRFDTQLMPPLAPQHTEFLLDQLDTSLLGLLGLSSPERLLNAAEFSHSLNQAITQYWNVASNVAYAPTNNTPVARLLKQLQLWRRADFGAVLLSHLRKFVLPTLALDYDASLRLVLRLIIDGFVDIHAVLQLFAGAAGDDFHNNGGERLAWDLLFCDEFELTPHDALLLACERKTYRVGHTAAFARHLVRVLCKAAIAAPRPASALTDVNLVAAGVGVGVDDLNPLSELSVVPVEQTPSARLLRASTKIRRPNALLSNGLWFVLAADRHLLLDSLRDAEQAKTQTHNLLALVGVAGEESAQAPLDSLVRKLNYFSLPLAQLLFARLLPETVRDEGPADLLLGLLAQLDGGSAVLAGDLFELLDDPLKLRVLHCCEELYLGSEQFPRLLVNGRNCTRMLMDIASACSRLREPKTIALSDSLVFSLNLSLEKLMYYCSNMDATRSLDDLEQAVMFVSRIVLIHRGFLVDLILKRSVNLQRDVFLVNLTKLFSHAVMERNFRLKNLLYDTLISLKVQLAEALNTPSQPATQTPQPPFITSLSLSKGTPTSSSFLSPTNSPLPTAGAQERTVHTMNITPPSYNNKLKFLLADPRFARLRDDALPENEHMYYLVDTAGETMVRFHVRGAELIEDATPNTGVNDACVSLQFFNASIEKKNPA
Length1390
PositionKinase
OrganismOgataea parapolymorpha (strain ATCC 26012 / BCRC 20466 / JCM 22074 / NRRL Y-7560 / DL-1) (Yeast) (Hansenula polymorpha)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Pichiaceae> Ogataea.
Aromaticity0.08
Grand average of hydropathy-0.026
Instability index41.59
Isoelectric point7.05
Molecular weight156252.40
Publications
PubMed=24279325

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33461
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.70|      20|      21|     731|     751|       1
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  731-  751 (32.93/24.80)	LLLDvRFDTQLMPPLAPQHTE
  752-  771 (33.77/20.46)	FLLD.QLDTSLLGLLGLSSPE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.15|      15|      21|     629|     649|       2
---------------------------------------------------------------------------
  629-  643 (31.86/10.43)	YPWFSARLRQDAVWL
  653-  667 (29.28/16.25)	YRLCDERFRQTAPFL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.68|      14|      17|     497|     513|       3
---------------------------------------------------------------------------
  497-  513 (19.17/17.88)	LKEPEHGVYSlsrFLLL
  540-  553 (24.51/13.47)	LQDADSSCYV...HLLI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.07|      17|      17|     841|     857|       5
---------------------------------------------------------------------------
  841-  857 (28.60/18.87)	DYDASLRLVLRLIIDGF
  859-  875 (29.47/19.69)	DIHAVLQLFAGAAGDDF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.67|      31|      40|     304|     339|       6
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  304-  339 (46.13/39.35)	LRAVSTVQQPRLLAEFRLLVqylfyYNSDAFIIPNS
  347-  377 (55.54/33.79)	LRAVIDLSYPPVCEQYRLIA.....YRNESMMIDES
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      83.63|      26|      42|      77|     103|       7
---------------------------------------------------------------------------
   77-   99 (30.03/18.49)	..................RTTPDVSEPGSR...WkMGLLSD..VMV
  100-  144 (28.60/13.19)	RALArrreinkirskstyRPPPRVTLTDHKrdlW.MRNLADasIPL
  187-  203 (25.00/10.62)	RQLK..............RKLPNPAALG.K...W.M..........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.64|      26|     180|     210|     235|       9
---------------------------------------------------------------------------
  210-  235 (45.79/32.84)	VVQFLEQVVAASFAPASRDA..............WRFRLS
  393-  432 (36.85/24.76)	VMQRLEAVRTLSLKMLCRDTfedssdddagaaddWKTTLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     255.35|      69|     354|     564|     650|      11
---------------------------------------------------------------------------
  564-  627 (98.48/51.27)	.....................ARNILRRLADSTGVALRTAEAPS....LQERLATALDSLPATFDLDALWPCDETDPEAEPLDIGSRAR
  898-  984 (83.71/36.66)	HDALLlacerktyrvghtaafARHLVRVLCKAAIAAPRPASALTdvnlVAAGVGVGVDDLNPLSELSVV.PVEQT.PSARLLRASTKIR
  986- 1039 (73.16/33.95)	PNALL........................SNGLWFVL.AADRHL....LLDSLRDAEQAKTQTHNLLALVGVAGEESAQAPLD......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.90|      16|      21|    1255|    1270|      12
---------------------------------------------------------------------------
 1255- 1270 (31.06/21.39)	TPSQPATQTP.QPPFIT
 1278- 1294 (24.84/15.33)	TPTSSSFLSPtNSPLPT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      28.76|      10|      21|     434|     448|      13
---------------------------------------------------------------------------
  434-  448 (11.90/17.47)	LLRwsittLREQDSG
  457-  466 (16.86/ 7.34)	LLR.....LQVQQLG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      30.54|      11|      16|    1051|    1063|      15
---------------------------------------------------------------------------
 1051- 1063 (11.35/13.89)	PlAQLLFArLLPE
 1070- 1080 (19.19/ 9.68)	P.ADLLLG.LLAQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33461 with Med12 domain of Kingdom Fungi
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