<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33458

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMSDAEVPPIPHVAANMTPLGVVLQRYAVHSYKQLSEYLKTLENTTQPDSVKKRNFLDILVSIRENFVRLYVLSKWARNSQSVEKLIDLFVWLREQNQSITNALMQIGGIKQSLVSAKLPNPDLETALEVLIKGRPQLPTHNYGPQKKIDPKLILHTLKTLDVELSAKMALEDNLPKPFYSYEIKDGRVKFRIPNLFQCCVSIANTYDQSGFFLVDFKLEFQSKDNKLIPQVTALPYMTFAHLEKVANIELSKNGLTGLYNIFHNYAITCKLYYLHRQLIRLRMGMWKGHLTHTYNAEKCFVVVTYWVKRRSVKSTIEIGKLKNNLLGFRWIREGRLCTDHDFTLENEDGSITIEHLIRDIIQKHIELHIKEVQQEVSDKIEMADKFVSLHKDSQLLLTLSSMKSAVYGIDALSGDGFFQNPTPIMARVAAQINADTRETALKLLVLRLETQLSELGSMLMATGWIGVDVVRLSTAEYTKLNIDYDHLKDRTFAEQLFALKFYRRKKWPSGWFLTVGVSGYSSKVQWWCSRIKSSAGQWSISWCESITLGGAESEYSYPSFVTLAKKTTSMLLCNLVVKELENQGCKLKTVDKSDEKVRQFTKQNFGLDLDSMQKGDSATVILDNKSLFNIPNCRDSLVLTMNIKNSELEIMIFGKLQSELKLSSISFNDEKNNSIELNPDTSIFKIHSQINLLEKLNYESTASFFNPLATTDISIMSDSLLVLNKFFSLLSLLHIISHDESLKVIDISLTKVSFQYGSNSEEMITLILLNETQDSISIELPKDNPHRLCSKYLNDMVSEFDFQKIKLLVRYLKLTLPFYKLLVKLSMDSEEFYRHFLEQNSNSQQLRMTPESGFELNMFDFEMFKITYYKYLERKSEKKVKTDRVCFALTIQLRHRTDKLSLDKSLFVISIEPLQFDQYDDTAKKWLQDTTNKIYATLKGDEPLPASGQVVYLRRAIACDYLSVENIVLQLHRKIITLCSSK
Length982
PositionTail
OrganismOgataea parapolymorpha (strain ATCC 26012 / BCRC 20466 / JCM 22074 / NRRL Y-7560 / DL-1) (Yeast) (Hansenula polymorpha)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Pichiaceae> Ogataea.
Aromaticity0.10
Grand average of hydropathy-0.209
Instability index39.03
Isoelectric point8.57
Molecular weight112996.34
Publications
PubMed=24279325

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33458
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     194.53|      65|      73|     594|     665|       1
---------------------------------------------------------------------------
  594-  665 (96.89/94.79)	DEKvrqftKQNFGLDLD.SMQKGDSATVILDNKSLFNIPNCRDSLVLT.MNIKNSELeiMIFGKLQSELKLSSI
  669-  735 (97.64/75.29)	DEK.....NNSIELNPDtSIFKIHSQINLLEKLNYESTASFFNPLATTdISIMSDSL..LVLNKFFSLLSLLHI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     158.77|      52|     210|     154|     212|       7
---------------------------------------------------------------------------
  154-  212 (72.55/72.79)	LHtLKTLDVELSAKMALEDNlpkpFYSYEiKDGRVKFRIPNLfQCCVSIANTYDQSGFF
  367-  418 (86.22/58.15)	LH.IKEVQQEVSDKIEMADK....FVSLH.KDSQLLLTLSSM.KSAVYGIDALSGDGFF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     108.31|      34|     157|     747|     785|       8
---------------------------------------------------------------------------
  747-  785 (52.20/41.10)	ISLTKVSF.QYGSNSEEMitlilLNETQDSISIELPKDNP
  909-  943 (56.11/33.78)	ISIEPLQFdQYDDTAKKW.....LQDTTNKIYATLKGDEP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33458 with Med14 domain of Kingdom Fungi
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