Description | Mediator of RNA polymerase II transcription subunit 11 |
Sequence | MSGRDVSYIQSRLDSLQEVDVRLVSMLDNLSTTLELLKSHKQAGVANEAEFKTAASGFYSDLSHAAVSLSKEVKTINNKITSQTGELDLLPVQINKKSVWVNDAKLREEIQYLDQLADFKSIEVPPDEPEKLEESPQEDKKVPETIDLDDIDMNDANT |
Length | 158 |
Position | Head |
Organism | Ogataea parapolymorpha (strain ATCC 26012 / BCRC 20466 / JCM 22074 / NRRL Y-7560 / DL-1) (Yeast) (Hansenula polymorpha) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Pichiaceae> Ogataea. |
Aromaticity | 0.04 |
Grand average of hydropathy | -0.551 |
Instability index | 46.69 |
Isoelectric point | 4.46 |
Molecular weight | 17665.49 |
Publications | PubMed=24279325 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364147 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP33454 No repeats found No repeats found |
MoRF Sequence | Start | Stop |
1) RDVSYIQS 2) SIEVPPDEPEKLEESPQEDKKVPETIDLDDIDMNDAN | 4 121 | 11 157 |
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