<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33447

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMNKLEDLNPLFCPASSNGSDYTPFEDRYPTLANYYKFALVSKINAYFYQVQEPPPKEAGGVSDTAKDEKISPLEQVHHYENSIKQQLARDYQISDVLTYGAKKEICIFRLETRLNPQDQELGFNQLKDAVDNIIIESKLSLKLASATTFDADSVFKSQANPQQQSRPSSIVYLSFLRALKKFLCQHLMARSSEVEILPFGNQSLVCSAQDTFQILKINTSLSIRNEIISNFAINSTPRFYRLSTLLDSEFDILKNNYALYLCPSGVRCSFANQNMLANSLSFEPPANYEKLLHLLSEYSHIKLEMPSRWIKLVPNLNHMNGLTPNIARYLESSAPNSKYIMWPASMCMIQFGDDLEESTFELSDSFELIEELILESDEEPKPLQISAIEEPTADSNPTDVDMDSAKESPGDWDELFGESMNEEEEEFHNDVPESESQSKPELVSSPVEKDARQFIELEPSNPLYEDPGAPSPASFHIFASPSPGTTDASSANDEVGSVTPKDIKKSIFAPLNFNPLIEKDIDSKYSNGGKFFVRSEAQSSRSQESASTTPTFWKNKKGEIDIEERDLISDSEEEIEEDDEDEDDDKTGLGISITSIPRNTGILSSMTPFVNQTAFSHPQAPSPQVSGAQEIQNWLFWILRGPALCTIPSRFLSTGNPIISKDKIELVLPIMQELVLFTTGMKHHYREQVSDLSELLESTLLSAFPGSSKMRLYELLDCDRPNSEMRLFDSLFGSEKEIYKLEAPRIEFDDPSFATTSPLMNITETENKRHSGIFKENANRAIADSVKSTSLFKISTTIFNTKRNDQDLKINETSLRYWKLLNLEPLEGQKNVRVILVIPKGTSYLLEKSRIFLQDLMATYSSWNLGQMSQLQDILEIPGGNFELFLQNAEGALTSLADSLRNQYLVDPNGQKDAILVMIAVPNIGMQLLTSLASVLEQFQSTLTMKAVDQETEEDRRKRRKRNISTIVSIPIFSFYKVIPLDLYLSKNESYSVVTSQKLGDLALEIYSLYPNKDISEPFKDRDRLLTISKQLPQKIPFVMTKAPISSGLIADDLFLHVCYERSIDKNWCVASWSDQYGEINFTRSWLISPDCRCQTFEEVSDEIFSISMDYVSSHNGKSYVILTRLNNVIPDDELTEWKRLSIKNNKLTLIVLTVELEPSTLVLSHLQEQKDDLKDMYSVKFTAASTNSQMLTPSVANRLESPMNGQTPSYDPGASPLDTSAFTGSQQQVPENPELIELSNECYGVILQVAQQLSNQSIRMPLRTGFIVNSGRRTAEGYEPGSIIELNLLSCQAGVNSIELLKNLIMQYKHLANLNKNPICPWHVSAVRRMIDFLVHLDVK
Length1341
PositionKinase
OrganismOgataea parapolymorpha (strain ATCC 26012 / BCRC 20466 / JCM 22074 / NRRL Y-7560 / DL-1) (Yeast) (Hansenula polymorpha)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Pichiaceae> Ogataea.
Aromaticity0.08
Grand average of hydropathy-0.371
Instability index54.61
Isoelectric point4.80
Molecular weight151329.20
Publications
PubMed=24279325

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP33447
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     324.21|     127|     408|     198|     335|       1
---------------------------------------------------------------------------
  123-  249 (152.56/113.82)	FNQLKDAVDNIIIESKLSLKLASATTFdADSV.FKSQANPQQ....QSRPSSIVYLSFLRALKkfLCQHLMARSS..........................eveilPFGNQslvCSAQdTFQILKINTSLSIRNEIISNFAINS...TPRFYRLSTLLdsE
  250-  335 (112.43/80.66)	FDILKNNYALYLCPSGVRCSFANQNML.ANSLsFEPPANYEKllhlLSEYSHIKLEMPSRWIK..LVPNLNHMNGLTPNI...ARYLESSAP.....................................................................
 1204- 1286 (59.22/31.11)	........................................................................MNGQTPSYdpgASPLDTSAFtgsqqqvpenpeliELSNE...CYGV.ILQVAQQLSNQSIRMPLRTGFIVNSgrrTAEGYEPGSII..E
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     126.92|      43|     131|     472|     528|       2
---------------------------------------------------------------------------
  427-  470 (70.01/33.83)	FH...NDVP.ESESQSKPELVSSPVEKDARQ..FIELEpSNPLYE...DPGAP
  475-  526 (56.91/62.53)	FHifaSPSPgTTDASSANDEVGSVTPKDIKKsiFAPLN.FNPLIEkdiDSKYS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     179.65|      56|     994|       2|      63|       8
---------------------------------------------------------------------------
    2-   63 (82.95/73.85)	NKLEDLNPLFCPASSNGSDYTPFEDRyPTLANYYKfALVSKINayFyqVQEPPPKEAGGVSD
  997- 1052 (96.70/60.93)	QKLGDLALEIYSLYPNKDISEPFKDR.DRLLTISK.QLPQKIP..F..VMTKAPISSGLIAD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33447 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EPKPLQISAIEEPTADSNPTDVDMDSAKESPGDWDELFGESMNEEEEEFHNDVPESESQSKPELVSSPVEKDARQFIELEPSNPLYEDPGAPSPASFHIFASPSPGTTDASSANDEVGSVTPK
2) TPSVANRLESPMNGQTPSYDPGASPLDTSAFTGSQ
379
1193
501
1227










Molecular Recognition Features






MoRF SequenceStartStop




1) GKFFVR
2) WDELFG
529
412
534
417