Description | Mediator of RNA polymerase II transcription subunit 7 |
Sequence | MSDLISSLYPPPPPYVRFFTAENVQRAAELRRQHGPDAEKLLSETKDLRFLVPPLPPNKPQYRSFGDIWNFEDKFITLEESGIQQLYEEAENVEEETFTVERIEELKKMTKSLLLNFLEFTGLLAKNPALAHVKIEQIRVILINLHHLLNSYRLHQSREGLILKMEEKIRNDRETIQKIENTCLQVEERIRSLVWREKDVEFEQVDNSQNAEPSREQIVESVRQSVLEGA |
Length | 230 |
Position | Middle |
Organism | Ogataea parapolymorpha (strain ATCC 26012 / BCRC 20466 / JCM 22074 / NRRL Y-7560 / DL-1) (Yeast) (Hansenula polymorpha) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Pichiaceae> Ogataea. |
Aromaticity | 0.07 |
Grand average of hydropathy | -0.577 |
Instability index | 59.69 |
Isoelectric point | 5.17 |
Molecular weight | 26967.33 |
Publications | PubMed=24279325 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery.
ECO:0000256 RuleBase:RU364060 |
GO - Cellular Component | core mediator complex GO:0070847 IEA:EnsemblFungi mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | negative regulation of transcription by RNA polymerase II GO:0000122 IEA:EnsemblFungi positive regulation of transcription by RNA polymerase II GO:0045944 IEA:EnsemblFungi |
Binary Interactions |
Repeats | >MDP33442 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 52.09| 15| 18| 156| 170| 1 --------------------------------------------------------------------------- 156- 170 (25.49/20.01) QSREGLILKMEEKIR 177- 191 (26.60/21.18) QKIENTCLQVEERIR --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 47.11| 12| 43| 8| 19| 2 --------------------------------------------------------------------------- 8- 19 (28.66/15.19) LYPP.PP..PYVRFF 51- 65 (18.46/ 7.97) LVPPlPPnkPQYRSF --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) LISSLY 2) PYVRFFTA | 4 14 | 9 21 |
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