<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33415

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMADLGQQTVEFSAVVRRAAEESFLSLKELVEKSPNQNDSEKKIRLLKYILNTRQRMLRLHVLAKWCRQNPLVQYCQQLSGTLSSHDTCFSQAADSLFFSHEGLQQARAPIYDVPSAIEILQTGTYKRLPKCIEDMGLLSLLSEDERKEAFEKLNPLMWSRLLEVVDQKEFSHVDVSEGTARFSVDGEFRVQLTLGYRGHLSMWRILHLELLVGEKNGPVKLEEMRRHALGEELERRMAAAEKPFVILKSVLHEFCIALVVDTVIRQLKTLQQGRWKDAIRFEVIADGSAGQGVHTQLPQDGDSDPSSSRTPGIKLMYWLEGDKNMGGSDLGSVPFIKIERGPDQQITCSHSTFIIDPLTGNEAELSLDLSCIDVEKLLLRVIACNRHTRLLEVHRELRSNSQICQAAGDVVLRCHILDKSEAASGKESFFGGFDGQWEEALSVRAFSTSYISLGINIRNGRFLFQSSRNVVVPSALAECEEALNQGTMTAAEVFISLRNKSLLHLFSSIGRFFGLKVYDQDSTALKIPKELMNGSDLLLMGFPQCGNSYYLLMQLDRDFKPLFTLLESEADPNGKSSLLGDANHVIRINKIDIGEMQMVEDEVNLSVLDLKKLLSPLKESGSANQILESGLHSSLNNDASVQFPGCPQSCFSSLADDVFDFEKAASLPQHLSVNNHVPLLVDSAPLSHLSSPQTSHQRITAGFISPRWEANSQFSQNSKISKVTISGPQFSNNPSFSSHSSKGLLETCPNNSLSPFGTVRSPSMQRLSISKSDQDLTSLKSVPHPVQVSSASGIDESSEEAHVMVSGNRPTHPLRTNDPRVLSSSSRTGLLRSSPTRHIGCPLRNPMSSVWATSPVCQTSETGIPDSMSDAVKKPEKTQRKRSLSDIIKLVPSLQEIEATTAMRKRRKMSESEIVPFRIAEASTLPASICKTRVLTYGDILDEANHGLAPSSIYATVLLHVVRHCSLCIKHARLTSQMDALDIPYVEEVGLRKPSSNLWFRLPRSGNDSWQHICLRLGRPGSMYWDVKVSDQHFRDLWELQRESNNTQWGPGVRIANTSDVDSHIRYDPDGVVLSYRTVEVNSIVKLVADLQRLSNALTFALGMRKLLGARAEDGPHESRGSNESRAVVGAKSVGEVGDKVAEQMRKTFRIEAVGLMSLWFSYLGSMPGIMARFVVEWEAGKEGCTMHISPDQLWPHSKFLEDFINGGEVASLLDCIRLTAGPLLALAGAIRPARMSGPGSAMPNITMGGSVQAGNKPNTFVASQGQVQSNNTSHPHQNPLNITTGNATALGPIGNHITQSAAMLSVAGRGGPGIVPSTLLPIDVSVVLRSPYWIRIIYRKNFAVDMRCFAGDHVWLQPATPPKGGPEAGGSLPCPQFRPFIMEHVAQGLNTLDANLIGGAASSTSVNSSSGNPTLTSITSQAPPPTTGARPNPASSAGIPRAIGPSGAVLNRVNPNLVGPSGSGAVNPGLPMRISPGSGLPVHVRGELNTAFIGLGDDGGYGGGWVPLAALKKVLRGILKYLGVLWLFAQLPNLLKDILGSILKDNEGALLNLDQEQPALRFFVGGYVFAVSVHRVQLLLQVLSVKRFHQQPQQQQQQQPNQNQTVSTQEELTQSEIAEICDYFSRRVASEPYDASRVASFITLLTLPIPVLREFLKLIAWKKGLLSQAQGQQQPGGGAGGEAAGPTQRPRVELCLENHGSWSPEEVPGSNEKPLNSRLGTSKSNIRYNRLNNSVDFGLTIVLDPTHIPHVNAAGGAAWLPHCVLVRLRYSFGESNHVTLIGVEGSHGGRACWPRVEDWDRCRQRVVRAVDLYGSGAAPPGADLSQGRLRMVAETLQRALLASLQQPRDGGS
Length1853
PositionTail
OrganismAmborella trichopoda
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Amborellales> Amborellaceae> Amborella.
Aromaticity0.06
Grand average of hydropathy-0.231
Instability index45.64
Isoelectric point7.73
Molecular weight202548.25
Publications
PubMed=24357323

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central
plasmodesma	GO:0009506	IEA:EnsemblPlants

GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
cold acclimation	GO:0009631	IEA:EnsemblPlants
positive regulation of cell population proliferation	GO:0008284	IEA:EnsemblPlants
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central
systemic acquired resistance	GO:0009627	IEA:EnsemblPlants









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33415
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      83.73|      18|      18|     803|     820|       1
---------------------------------------------------------------------------
  786-  802 (24.41/13.12)	VQVSSASGIDE.SSEEAH
  803-  820 (32.50/20.51)	VMVSGNRPTHPLRTNDPR
  821-  837 (26.81/15.31)	VLSSSSR.TGLLRSSPTR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.49|      15|      18|     633|     648|       2
---------------------------------------------------------------------------
  633-  648 (25.61/19.99)	SSLNNDAsVQF...PGCPQ
  652-  669 (21.88/11.33)	SSLADDV.FDFekaASLPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     441.02|     133|     158|    1185|    1325|       3
---------------------------------------------------------------------------
 1185- 1325 (213.59/144.55)	CtmhISPDQLWPHSKFLEDfiNGGEVASLLDCIRLTAGPLLALAGAIRPARMSGPGSAMPNITMGGSvqAGNKPNTFVASQGQVQSNNTSHPHQNPLNITTGNATAlGPIGNHITQSAAMLSVAGRGGPG....IVPSTLLPIDV
 1349- 1485 (227.43/132.17)	C...FAGDHVWLQPATPPK..GGPEAGGSLPCPQFRPFIMEHVAQGLNTLDANLIGGAASSTSVNSS..SGNPTLTSITSQAPPPTTGARPNPASSAGIPRAIGPS.GAVLNRVNPNLVGPSGSGAVNPGlpmrISPGSGLPVHV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.30|      25|     557|     567|     598|       5
---------------------------------------------------------------------------
  320-  344 (46.35/23.13)	EGDKNMGGSDLGSVPFI....KIERGPDQ
  569-  597 (38.95/29.04)	EADPNGKSSLLGDANHVirinKIDIGEMQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.89|      11|     158|     986|    1000|       6
---------------------------------------------------------------------------
  986- 1000 (16.67/17.70)	VEEVGLRkpssNLWF
 1151- 1161 (22.22/11.24)	IEAVGLM....SLWF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.13|      17|      19|     704|     722|      11
---------------------------------------------------------------------------
  704-  722 (28.40/20.99)	IS.PRWEANSQFSQNSkiSK
  725-  742 (28.72/14.94)	ISgPQFSNNPSFSSHS..SK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.10|      16|     196|     887|     909|      12
---------------------------------------------------------------------------
  881-  901 (15.84/23.19)	KRSLsdiiKLVPsLQEIEATT
  906-  924 (22.26/ 7.63)	RRKM.sesEIVP.FRIAEAST
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.19|      17|      18|    1503|    1520|      15
---------------------------------------------------------------------------
 1503- 1520 (25.48/17.82)	GGGWVpLAALKKVLRGIL
 1524- 1540 (30.71/16.44)	GVLWL.FAQLPNLLKDIL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.17|      28|      73|    1594|    1622|      17
---------------------------------------------------------------------------
 1594- 1622 (45.36/30.36)	QQQQQQQPNQNQTvSTQEELTQSEIAEIC
 1669- 1696 (51.81/30.77)	QAQGQQQPGGGAG.GEAAGPTQRPRVELC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.20|      18|      18|    1049|    1066|      18
---------------------------------------------------------------------------
 1048- 1065 (33.58/24.85)	QWGP.GVRIA.NTSDVDSHI
 1066- 1085 (21.63/12.75)	RYDPdGVVLSyRTVEVNSIV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33415 with Med14 domain of Kingdom Viridiplantae
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