<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33389

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMESFVQLVENCCARGIAAQQFLNFYHEFINEKYEASLNNGNEEREVESRKQVFQHVSEELLTVLQSCSGNQETLLAEYMVHLVFINYDTDLSSALLPRIYSIQSEQLLLHFHSLATSFIGRLEDNLIKDQMRQDLSTFIIPSCLRIDMSTFSNQLFIAVVKYLQALLSLVDGVLEVEMDKEKMKLALSSILTRANKLNRIMGKRVCRDFETKLNVSLASEPSSNKLAAMSSPAIFSPSLGNGIGSGAGMGSLASRLVGTPGSVRPMDMSASSSGPSAPSAASRIQDLKLIRFYKNLWLNNKIHNFNTTDAQFLEKFSSINYRLSSTGMEEHMMEEKITDLIETAYTSFAQLVNNKLYHQTNTHFNLLERKYVHFITKRLPLIIRDFLPQNPSVIVNALQNMDDKVKKAIKSYYSNKNDSPESNEDLFDDYSGNNFDIRHDFLKNLIMLNLRPPSVLNVFLREDQMVDTKTLKTDDSLSIVNSQGVQEKITDLHGTLKSLLSDLDIENQYIGNGTNYQFSPDNSLLKLLMSFDTIAPTKQVEISSAFVQILQTSIENSDLKTLGKVLWVLTTNIGHVTTSMLCCLSPDPFMSTVIGFIDKRQQSSSMSASDEPDFESLHGYITFGMALSFIVFMNKTYGVNVEQYVDNYDTSYAIKFLSTIQEIPNSFVLQHGSPEESNSYLQNWLKDLFINGSISDTQMKNADIKDLINLVPFIFKQSLVAVQSGSVQNMSNISSGSEYFLQPFILPGLIKIMFWLEYYLKSLKSNNPPPQILSSCWELLNIIISPSSLDDDAKGLHFVILKLNCVRLLNVLHMFRNDESNSGQYGVYATHESIDPKLESLISKFEYVASISNIYDVDPKFYETTKEGYSHGTLFSSKIPITNDMPVDKIMTNQLNSFWNLHSSTYYNYDYLLELVKLITPEKFLLDSIKTLTYKVAAYGVPGIQGKLNTSAIEQVANFFAYFMVLHDVQTEEQRLALLNYIETGVIATNKDIEAKPEPETKIDDDFDMLFGEPFNNTVEDTSVVFSQNDQPKGNSFSTVYPVFVGTFGVIIAEMKNRFDKSKAQGILTEEEYQKSTTFTRKYLDNLKNSVV
Length1092
PositionTail
OrganismKluyveromyces marxianus (strain DMKU3-1042 / BCC 29191 / NBRC 104275) (Yeast) (Candida kefyr)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Kluyveromyces.
Aromaticity0.10
Grand average of hydropathy-0.182
Instability index42.39
Isoelectric point5.17
Molecular weight123506.07
Publications
PubMed=25834639

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:EnsemblFungi

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
histone H3 acetylation	GO:0043966	IEA:EnsemblFungi
regulation of transcription by RNA polymerase II	GO:0006357	IEA:EnsemblFungi
transcription by RNA polymerase II	GO:0006366	IEA:EnsemblFungi









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33389
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     133.23|      43|     259|     416|     466|       1
---------------------------------------------------------------------------
  416-  466 (68.03/56.71)	KNDSPE.SN.......EDLFDDYSGNNFDIRHDFLKNLImlNLRPpsvlnvFLREDQMV
  670-  720 (65.20/37.23)	QHGSPEeSNsylqnwlKDLFINGSISDTQMKNADIKDLI..NLVP......FIFKQSLV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     348.86|     116|     221|     510|     644|       2
---------------------------------------------------------------------------
  510-  644 (172.27/166.13)	IGNGTNYQFSP..DNSLLKL.......LMSFDTIAPTKQVeISSAFvQILQTSIENSDLKTLGKVLwvlttnigHVTTSMLCCLspdPFMSTVIGFIDKRQQSS..SMSASDE...PDFESLHGYITFGMALSFIvfmnktYGVNVEQY
  733-  862 (176.59/122.39)	ISSGSEYFLQPfiLPGLIKImfwleyyLKSLKSNNPPPQI.LSSCW.ELLNIIISPSSLDDDAKGL........HFVILKLNCV...RLLNVLHMFRNDESNSGqyGVYATHEsidPKLESLISKFEYVASISNI......YDVDPKFY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.49|      23|     149|     334|     357|       3
---------------------------------------------------------------------------
  334-  357 (35.22/29.19)	EEKITDLIETAYTSFAQL.VNNKlY
  486-  509 (35.27/23.89)	QEKITDLHGTLKSLLSDLdIENQ.Y
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     102.61|      25|      27|     232|     256|       4
---------------------------------------------------------------------------
  209-  228 (18.74/ 7.02)	...FETKLNVSLASEPSSNKLAA..
  232-  256 (41.90/24.88)	PAIFSPSLGNGIGSGAGMGSLASRL
  260-  284 (41.97/24.93)	PGSVRPMDMSASSSGPSAPSAASRI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.73|      17|      51|     120|     136|       7
---------------------------------------------------------------------------
  120-  136 (29.66/23.25)	GRLEDNLIKDQMRQDLS
  172-  188 (28.08/21.58)	GVLEVEMDKEKMKLALS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33389 with Med5 domain of Kingdom Fungi
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