<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33388
Description |
Mediator of RNA polymerase II transcription subunit 1 |
Sequence | MSDTFVETLNEMIQMLLNYKPGNRTLSNVIKLCQTLGLESFVDQVDTNKSRLSIASNIVVIDIDYENEMETILDVKLVLASNFDKFNYFNEQGENILLTSLSNVQDLKAFHHNLNFLVFLDSFSNIDIESGHTSLDLFKYYSDLPKMLQDYLQDQHLPFQVKVNENSTFGIVIYDANGENAIGTVCLERAPNSDSPFYEYIYDPKLKEWVNESSDASTQGINLVLKFADVIGFPETWITQELRVDNSTPLKTFAIPQQPQLKNSVKLQNELTSELLLMDTFRISNEDISLLPDFLKWYLWHKLVLEEMLKAITLDPSSSGNALNAGNSGTMQAKPRRRSSIMGNRKPSMSESMMLRDSGISQFTLKEIMDQPAVSDTEGDDMMDIDNDDNNKLVCITLNEEYICVGKTQKCSYQDDSQETWVSVIEFLKSKLL |
Length | 433 |
Position | Middle |
Organism | Kluyveromyces marxianus (strain DMKU3-1042 / BCC 29191 / NBRC 104275) (Yeast) (Candida kefyr) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes>
Saccharomycetales> Saccharomycetaceae> Kluyveromyces.
|
Aromaticity | 0.09 |
Grand average of hydropathy | -0.299 |
Instability index | 38.47 |
Isoelectric point | 4.49 |
Molecular weight | 49312.23 |
Publications | PubMed=25834639
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364059
|
GO - Cellular Component | core mediator complex GO:0070847 IEA:EnsemblFungi
mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | negative regulation of transcription by RNA polymerase II GO:0000122 IEA:EnsemblFungi
positive regulation of transcription by RNA polymerase II GO:0045944 IEA:EnsemblFungi
|
Interaction
Repeat regions
Repeats |
>MDP33388
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 356.58| 113| 140| 135| 255| 1
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135- 255 (175.56/149.94) LDLFKYYSDLPKMLQDYLQdQHLPFQVKVNEnsTFGIVIYD....ANGENAIGTVCLERAPNSDSPfyeyIYDPKlKEWVNESSDASTQGIN.LVLK.FADVIGFPETWITQELRVDNSTPLKTFAI
278- 396 (181.02/127.52) MDTFRISNEDISLLPDFLK.WYLWHKLVLEE..MLKAITLDpsssGNALNAGNSGTMQAKPRRRSS....IMGNR.KPSMSESMMLRDSGISqFTLKeIMDQPAVSDTEGDDMMDIDNDDNNKLVCI
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 52.78| 18| 19| 89| 107| 2
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89- 107 (25.19/16.44) FNEQGE.NILLTSLSNVqDL
110- 128 (27.58/13.81) FHHNLNfLVFLDSFSNI.DI
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