<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33381

Description Serine/threonine-protein kinase SSN3
SequenceMSYYRLNNGQGGNNNRWPQQLSHQEMLANHSKLILDKNKPAGTQSKPPIVMASNNVFSIGPYRQRKDSSRVSVLQKYEIIGYIAAGTYGKVYKAKSRDYDNNRNGNDVIVLDSPDPISADSNLDINSINRSTRQHEANENLTTTDFRKPFNKRFTPNERNNSTQIRFNSGSEQNTGMNSSNLTNNSRKPSQIQFYAIKKFKTEREGVEHYTGISQSACREMSLCRELDNNHLTKLVEIFLEKKSIYMVSEFAEHDLLQIIHFHSHPEKRLIPSRMLKSIMWQILDGVSYLHQNWILHRDLKPANIMVTVDGCVKIGDLGLARKFNNMIQTLYTGDKVVVTIWYRAPELILGARHYTPAIDLWAVGCIFAELIGLRPIFKGEEAKMESKKSVLFQANQFQRILEVMGTPDHKIWPNISSYPEYPQLAKMPKYRESLTTWYQTAGGKDKAALDILYRLLTYDPIRRIDAIDALDHPYFTNGDPPVCENVFEGLNYKYPPRRIHTNDNDITNVGNDNNPNHSQKQTIHSNNNNKNGSINGLGVNKRVLAAAAAAAAAAAVSGNGNNPSNNNMAAGGSVRKKRK
Length580
PositionKinase
OrganismKluyveromyces marxianus (strain DMKU3-1042 / BCC 29191 / NBRC 104275) (Yeast) (Candida kefyr)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Kluyveromyces.
Aromaticity0.08
Grand average of hydropathy-0.645
Instability index37.58
Isoelectric point9.46
Molecular weight65629.44
Publications
PubMed=25834639

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:EnsemblFungi

GO - Biological Function
ATP binding	GO:0005524	IEA:InterPro
cyclin-dependent protein serine/threonine kinase activity	GO:0004693	IEA:EnsemblFungi
RNA polymerase II CTD heptapeptide repeat kinase activity	GO:0008353	IEA:EnsemblFungi

GO - Biological Process
negative regulation of filamentous growth	GO:0060258	IEA:EnsemblFungi
negative regulation of transcription by RNA polymerase II	GO:0000122	IEA:EnsemblFungi
nuclear-transcribed mRNA catabolic process, non-stop decay	GO:0070481	IEA:EnsemblFungi
phosphorylation of RNA polymerase II C-terminal domain	GO:0070816	IEA:EnsemblFungi
positive regulation of transcription from RNA polymerase II promoter by galactose	GO:0000435	IEA:EnsemblFungi
protein destabilization	GO:0031648	IEA:EnsemblFungi
response to oxidative stress	GO:0006979	IEA:EnsemblFungi









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33381
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      77.45|      17|      34|     170|     186|       1
---------------------------------------------------------------------------
  131-  145 (21.17/ 8.80)	STRQHEA.NE.NLTTTD
  153-  169 (25.20/11.68)	RFTPNERNNSTQIRFNS
  170-  186 (31.08/15.88)	GSEQNTGMNSSNLTNNS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      92.79|      25|     110|     320|     344|       2
---------------------------------------------------------------------------
  320-  344 (45.80/32.92)	L....................AR..KFNNMIQTLY..TG..DKVVVTIWYR
  374-  413 (18.57/ 9.06)	LrpifkgeeakmeskksvlfqAN..QFQRILEVMG..TP..DH...KIW..
  425-  455 (28.42/17.69)	L....................AKmpKYRESLTTWYqtAGgkDKAALDILYR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.32|      16|     111|     262|     282|       3
---------------------------------------------------------------------------
  262-  277 (29.41/28.90)	FHSHPEKRLIPSRMLK
  286-  301 (29.91/14.19)	GVSYLHQNWILHRDLK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.59|      23|     426|      38|      63|       5
---------------------------------------------------------------------------
   38-   63 (38.28/28.85)	NKPAGTQSKPPIvmaSNNVFSIGPYR
  472-  494 (46.30/27.06)	DHPYFTNGDPPV...CENVFEGLNYK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33381 with CDK8 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DSNLDINSINRSTRQHEANENLTTTDFRKPFNKRFTPNERNNSTQIRFNSGSEQNTGMNSSNLTNN
2) RRIHTNDNDITNVGNDNNPNHSQKQTIHSNNNNKNGSING
120
498
185
537










Molecular Recognition Features






MoRF SequenceStartStop




1) KRVLAAAAAAAAAAAVS
2) MSYYRLNN
3) NNNMAAGGSVRKKRK
542
1
566
558
8
580