<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33379

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMKETVGEACRLEDIITNIYRLERVSQINYQQYVPSKTDNQWSIQAELYLRRKNPRVLAALFSRELWCFSINDDPLPELDFKVGNESDVPQPERKGHFTPEFSKPNLPTPYAIFMKALRRTVYVNLTLSSNKGIIPFGNSCIFQEDYTSATKLLHFDPHLFENGDLTVAICSKDLGLAKLKPETLSTDSAVYLAPSGIRVYLPSCDLKKCYVPPPKNATMFLKTLYISHGINLTNEEDLKWVKLIPNASHLNGFTPTISHYLDQPKGTNYVVWPASLCFVQKASDSKSSPYSLVSNSPKFELDDCFDMVDGFIQLKLTSAYRTPGASAGMGTVTGHNPMSTGGVFTDQFQGFNKHSENVGNNVPSTGDNSKGSPDLSNDPNKTPGKEMKSQRQPFSADGYGSAGFITTPIINENITPTVDDLIMETPSVKPQNDLWNEKKDIVNVNTSQESRDPYPPSANAAKVEENNETLHNPNYGNQNTDDVELPPDNDDFDKDLFGEDSDEDVSEKSNNESLASVKEITDEMFDMADNDMDVEVSSTFSATSENQHPSIDSSETTDKKTRTKRTYLDIPVDDITIETTPSLYEDPGAPLPIETPKDRKKSIYAPLNFNPIFESNVDNKYKNGGKFSFNPNSNDEPLQFGISTSNVSSSEDEDSDFSPSENNNGFSASRILPYDSRDNEIPILEPPSYEPLSKDTLPDLINPPSASKDESVVSSYNMMGPVLDKSMKSNLEAIWKPSSLNKVEKPQLSNVQNNENNIEENSPITSNPTVFYEGTPFPRQDSPYSNLKQKNISSNTVPSGDVEQKADQILQNSEQDHTESSRILPYLLRHMPLFSLPDIFLSQNPTLPSGKDLDDVLDILTDQIVFNNRLFFDDHKDDFKYKGIKECSGGIISDTMKSLFSNFSKLHGNEIIEEIFYMPEPSVFVKKADNTIKIRSSSSYFSEYLSLKPNRGVKNFRALVLTTEAKNDCMSFVSQMSQTYSNHELGFCELTKLTNEDDKGLVYLKNFNQDTLLLLSAQIVSFCSTTLSNVKNVPLLIFLPINKLSLSECISMILKFHVIRKEVKSKLPKADILLNLVDFDFLKNPLTPSGAYTSLCMSIYNCLPPKGTKVTTLTNDLPKDIKFRTLNNTSLSIHYDNYIHLAYLRSIDREWLSAAWSDTEGVESFVRTWYVGNSRTRFEEVCNEMWKITLQLASKKFGNVCLVLTRLDSVLPDDELIHWRRLSVATKDLHLAVVCVGDNTKLSLFDEDKTYPTFKNLFRSNGNNDLETTGNIDNYEIVNIDEEVHGVMFSNPLQLANSQHRCAIKSGALIRFAKSEGDSFIDKFEVNLLNCPHADSSTLLKEILKQYRNLAGLNSWFGVSRGKDNYIPWHVVAVKNVMDSIVHVKSSFEKETYIID
Length1396
PositionKinase
OrganismKluyveromyces marxianus (strain DMKU3-1042 / BCC 29191 / NBRC 104275) (Yeast) (Candida kefyr)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Kluyveromyces.
Aromaticity0.09
Grand average of hydropathy-0.501
Instability index40.38
Isoelectric point5.00
Molecular weight156929.23
Publications
PubMed=25834639

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:EnsemblFungi

GO - Biological Function
transcription coactivator activity	GO:0003713	IEA:EnsemblFungi

GO - Biological Process
negative regulation of transcription by RNA polymerase II	GO:0000122	IEA:EnsemblFungi
positive regulation of transcription from RNA polymerase II promoter by galactose	GO:0000435	IEA:EnsemblFungi









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33379
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     832.48|     148|     148|     624|     771|       1
---------------------------------------------------------------------------
  195-  305 (96.10/45.11)	................................................................SGIRVyLP...ScDLKK.CYVP...PPK.NATMFLK.TLyishgI...NLTNEEDLKWV.KLIPNASHLNGftPTishyLDQPKGTNY.VVW.PAS..LCFVQKA..SDSKS.SPYSLVSNSPK.FEL.DDCF
  324-  463 (152.00/76.09)	GASAGMG..T...VTGHNPM....STGGVFT.....DQ...FQGFNkhsenvgnnvPSTGDN....SKG.SP...D.LSNDpNKTPGKEMKSqRQPFSAD.GY...gsA...GFITTPIINENiTPTVDDLIMET..P........SVKPQ.NDLW.........NEKKDIVNVNT.SQES.RDPYPP.SAN.AAKV
  466-  621 (170.57/86.38)	NNETLHN..PnygNQNTDDVELPPDNDDFDKdlfGEDS...DEDVS..........EKSNNESLASVKE.ITdemF.DMAD.NDMDVEVSST.FSATSEN.QH.....P...SIDSSETTDKK.TRTKRTY.LDI..PV....DDITIETTPSLYEDPGA..PLPIETPK.DRKKS.IYAPLNFN.PIfESNvDNKY
  624-  771 (240.45/125.10)	GGKFSFN..P...NSNDEPLQFGISTSNVSS...SEDE...DSDFS..........PSENNNGFSASRI.LP...Y.DSRD.NEIPILEPPS.YEPLSKD.TL.....P...DLINPPSASKD.ESVVSSYNMMG..PV....LDKSMKSNLEAIWKPSS..LNKVEKPQLSNVQN.NENNIEENSPI.TSN.PTVF
  774-  924 (173.36/87.92)	GTPFPRQdsP...YSNLK..QKNISSNTVPS...GDVEqkaDQILQ..........NSEQDHTES.SRI.LP...Y.LLR...HMPLFSLPD.IF.LSQNpTL.....PsgkDLDDVLDILTD.QIVFNNRLFFD.........DHKDDFKYKGIKECSGgiISDTMKSLFSNFSKlHGNEIIEEIFY.MPE.PSVF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     342.50|     111|     149|    1115|    1236|       2
---------------------------------------------------------------------------
 1115- 1236 (172.25/110.37)	NDLPK..DIKFRTLNNTSLSIH...YDNYIHLAylRSIDREWL.SAA...WSDTEGvESFVRTWYVgNSRTrfeevCNEMWKIT.LQLASKKFGNVCLVLTRLDSVLPDDELIHWRrlSVATKDLHLAVVCV
 1264- 1384 (170.25/85.32)	NDLETtgNIDNYEIVNIDEEVHgvmFSNPLQLA..NSQHRCAIkSGAlirFAKSEG.DSFIDKFEV.NLLN.....CPHADSSTlLKEILKQYRNLAGLNSWFGVSRGKDNYIPWH..VVAVKNVMDSIVHV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.17|      20|      56|      96|     117|       4
---------------------------------------------------------------------------
   96-  117 (33.65/26.67)	HFTPE.FSKPNLPTpyAIFMKAL
  154-  174 (34.53/19.43)	HFDPHlFENGDLTV..AICSKDL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33379 with Med13 domain of Kingdom Fungi
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