<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33377

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMTLQMNGISEYDPEKGIPLAIDPNLIDIPSITAPLGANGIVHDDTASKDSDSTSVEDQTSKKSQRSLIQNPYELFGQMSLEQFIPLMLKQRGPGTKFADIHEDVLQQEIEQEQNQGQMSSEDKSVQLGEVTVDGLEQNTSGMEQEQNVKKKDGDGDIEMTDSVTHPEKPEVSNEIPDEHLNTIPNSDETISHEEFINIKKSVLEHVTMALNESSLSLEFISLLLSSTRTSAGISSMSPYLKKIAPPASLNADKVPLEMLNEHDKLIYDITQKGWNLRSLEDCKRLLKQHYQILLKSVDSESTYWNQISDNISNKDVLFKMKDRNTGRRTLGIKYGFDDSGSSYTADKGIALLRATSEGSELELVPVLDSEANMGITKSSPEQFVRVRIFTKIEQEDDYLLSGQSSLNEILLNNNKDIKSQIARLRFFIFEKELMHHLKVEAGQLLPYGVSVENENKVVLELPNEKIEFELVNLDEEVISNYQQEAAKINNKRANLILVMLNMLQVVMYKKQLWKRMNPSPNASKGHITYGKDLVLLRAILGKIRHKRYKQLIEKIIHNTILNKKEGLMMTVKEDIISNDNEFSKNKELATLQREIALFDKVLSMPRTDFTITIPEKGKVDLSLRSTNHCNAVVFMKYVNEEEVVKFDTKFSEFTEFEEFMNFVYNEFFI
Length669
PositionHead
OrganismKluyveromyces marxianus (strain DMKU3-1042 / BCC 29191 / NBRC 104275) (Yeast) (Candida kefyr)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Kluyveromyces.
Aromaticity0.07
Grand average of hydropathy-0.483
Instability index48.58
Isoelectric point5.08
Molecular weight76147.62
Publications
PubMed=25834639

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364140
GO - Cellular Component
core mediator complex	GO:0070847	IEA:EnsemblFungi
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
activating transcription factor binding	GO:0033613	IEA:EnsemblFungi
RNA polymerase II complex recruiting activity	GO:0001139	IEA:EnsemblFungi
RNA polymerase II core promoter sequence-specific DNA binding	GO:0000979	IEA:EnsemblFungi
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
positive regulation of transcription by RNA polymerase II	GO:0045944	IEA:EnsemblFungi

Interaction

Binary Interactions











Repeat regions





Repeats
>MDP33377
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.08|      18|      38|     377|     395|       3
---------------------------------------------------------------------------
  377-  395 (26.59/23.83)	KSSPEQFVRVRIFTkIEQE
  415-  432 (30.49/21.85)	KDIKSQIARLRFFI.FEKE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.37|      12|      31|     103|     114|       5
---------------------------------------------------------------------------
  103-  114 (22.16/14.40)	DVLQQE...IEQEQN
  133-  147 (18.21/10.53)	DGLEQNtsgMEQEQN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33377 with Med17 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GANGIVHDDTASKDSDSTSVEDQTSKKSQRSLIQNP
2) GTKFADIHEDVLQQEIEQEQNQGQMSSEDKSVQLGEVTVDGLEQNTSGMEQEQNVKKKDGDGDIEMTDSVTHPEKPEVSNEIPDEHLNTIPNSDET
36
94
71
189










Molecular Recognition Features






MoRF SequenceStartStop




1) IQNPYEL
68
74