<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33376
Description |
Mediator of RNA polymerase II transcription subunit 16 |
Sequence | MPLISESSNESRALERKFSSASWSKTGLIAYSENSRPDCNLSLTFLETVNGTNWKFHDPYHYLIHTHMYDDISNNISSSSSNSKQTQFFYDIDFVKWNNWSLLGGELLAISDSIGNLTILAASLNEEGNTTYDSLSMLFQDTVFKVHNKFLHLVPTNGSNENKTITKLERKETKKEYMTRILDFQWCGNSKPILTPLGAMKTPHTDPPFYKNHIQNCTPIGVFHPASVKHAFVAIRTNGVIDFWYQLSNSKDFKKISLQINQGSRQNEFEWLEKASIAHMDEDQCFIIGAFSNSTQNIDFYKLKVDWNNNGGTVNDPILHLSHIYELKPETTYKSSNLIKISNLKILSRTPIPNSKPEILITYRLINKGENISTFRSIVKRYQLSQNSLDESFSEILNITPVSQRTAQYSLKVIETMELKQVLKSISAEDLCISAAFEYESGEIDIYSRNNWKLQSDTIDKNSDIYDKPFIPSMFSVGFKYQNIPTQSNIEWSIISPSMGGTLIKYYEKPLPIFRAAVNDVVSDQSRDQVHATGLALVFVILSHRNFSGEDITITIKTHVLRLQELDPDRAINFISLLISTIFGLYGLVLDGTKGTLDKALQSKAVQNILLLQMELGPHISASKNIYSVGYIAMKLRNMNIAFNGVARNVQAMIQHTSNINMLPNGKVFQFAFSKQDLIYSLLPSAKWIVMFISYVTQQLILAVNNASYFDKSFLITLFGSRIIRHLMFKVIGELKNIANIMVKFPETAFPILNESSQFFRKVINDCTVNLDSFATFISEFGSKINEVDQSTVIVQQRYEADFLIKGIAPESLSDFDKILRTAALKFLLPHVNLAVVFFTETSFLNLRWEEKFDREVLELQKPISEGLLIYDNKSSSGLNVPDVVYDDVTSEHVNIKGRSVIKKCCRCGTYTRAGYPVDGDNTIVPTSIVTKRWTALYYRNCHCTGLLYEVKLK |
Length | 954 |
Position | Tail |
Organism | Kluyveromyces marxianus (strain DMKU3-1042 / BCC 29191 / NBRC 104275) (Yeast) (Candida kefyr) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes>
Saccharomycetales> Saccharomycetaceae> Kluyveromyces.
|
Aromaticity | 0.11 |
Grand average of hydropathy | -0.172 |
Instability index | 39.85 |
Isoelectric point | 7.58 |
Molecular weight | 108421.69 |
Publications | PubMed=25834639
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364149
|
GO - Cellular Component | core mediator complex GO:0070847 IEA:EnsemblFungi
mediator complex GO:0016592 IEA:EnsemblFungi
|
GO - Biological Function | RNA polymerase II activating transcription factor binding GO:0001102 IEA:EnsemblFungi
|
GO - Biological Process | negative regulation of transcription by RNA polymerase II GO:0000122 IEA:EnsemblFungi
positive regulation of transcription by RNA polymerase II GO:0045944 IEA:EnsemblFungi
regulation of establishment of protein localization to chromosome GO:0070202 IEA:EnsemblFungi
RNA polymerase II preinitiation complex assembly GO:0051123 IEA:EnsemblFungi
|
Interaction
Repeat regions
Repeats |
>MDP33376
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 246.77| 78| 89| 20| 103| 1
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20- 103 (130.90/111.80) SASWSKTGLIAYSENSRPDC...NLSLTFLETVngtnWKFHDPYHYLIHTHMYDDiSNNISSSSSNSKQTQFFYDI.DFvKW..NNWSLL
111- 194 (115.88/80.55) SDSIGNLTILAASLNEEGNTtydSLSMLFQDTV....FKVHNKFLHLVPTNGSNE.NKTITKLERKETKKEYMTRIlDF.QWcgNSKPIL
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 82.18| 23| 91| 743| 765| 2
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743- 765 (41.01/31.62) VKFPETAFPILNESSQFFRKVIN
837- 859 (41.17/31.79) VFFTETSFLNLRWEEKFDREVLE
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
5| 226.28| 37| 39| 434| 470| 4
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250- 286 (45.51/24.80) SKDFKKISLQINQ.GS.RQNefeW.LEKASIAHM....DE..D.QCF
288- 330 (44.80/24.29) IGAFSNSTQNIDF.YKlKVD...WNNNGGTVNDPilhlSHIYElKPE
349- 372 (22.66/ 8.72) RTPIPNSKPEILItY.........RL....INKG....ENI......
434- 470 (63.63/37.55) SAAFEYESGEIDI.YS.RNN...WKLQSDTIDKN....SDIYD.KPF
476- 511 (49.68/27.73) SVGFKYQ..NIPT.QS.NIE...WSIISPSMGGT...lIKYYE.KPL
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 55.10| 18| 19| 662| 679| 5
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662- 679 (32.81/21.80) MLPNGK.VFQF.AFSKQDLI
682- 701 (22.29/12.51) LLPSAKwIVMFiSYVTQQLI
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 45.40| 14| 19| 603| 616| 6
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603- 616 (21.86/13.14) SKAVQNILLLQMEL
623- 636 (23.54/14.66) SKNIYSVGYIAMKL
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 37.64| 11| 59| 713| 723| 7
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713- 723 (21.18/10.45) SF..LITLFGSRI
773- 785 (16.47/ 6.73) SFatFISEFGSKI
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 56.66| 18| 19| 385| 402| 8
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375- 392 (27.77/19.67) FRSIVKRYQLSQNSLDES
393- 410 (28.89/20.78) FSEILNITPVSQRTAQYS
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