<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33373

Description Mediator of RNA polymerase II transcription subunit 2
SequenceMAAKGVVAEKQDNKLTQCFDDILRLAADLLSQQQLKTIKLDPQVTTGFSQAQQKVLKDRLTHFYSLIDTLDVSLQTTAEYVDAVKANAIQIKKQREEEELRKQEQQKLEQQKLEQQKLEQQKLEQQKLEQQKLEQQKLEQQKLEQQKLEQQKLEQQKYSAKNTPMDMLTTFDSDLPSAGVAQPQGFNSDFGDLNGMDLSMFDSMDNQGSFGGLQSSSGMNEKKNDPQMNFNDTNAPPSAVAVPESENPNSYLTLNDFNDLGIDWNAANDNNELNLEDFNL
Length280
PositionTail
OrganismKluyveromyces marxianus (strain DMKU3-1042 / BCC 29191 / NBRC 104275) (Yeast) (Candida kefyr)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Kluyveromyces.
Aromaticity0.06
Grand average of hydropathy-0.935
Instability index46.11
Isoelectric point4.53
Molecular weight31811.94
Publications
PubMed=25834639

Function

Annotated function 
GO - Cellular Component
GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33373
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     101.57|      19|      19|     104|     122|       1
---------------------------------------------------------------------------
  104-  122 (39.06/19.97)	EQQKLEQQKLEQQKLEQQK
  124-  142 (39.06/19.97)	EQQKLEQQKLEQQKLEQQK
  144-  157 (23.45/ 9.37)	EQQKLEQQKLEQQK.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.36|      12|      18|     247|     258|       2
---------------------------------------------------------------------------
  247-  258 (23.96/15.72)	NPNSYLTLNDFN
  268-  279 (22.40/14.22)	NDNNELNLEDFN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     100.91|      24|      29|     165|     188|       4
---------------------------------------------------------------------------
  165-  188 (44.46/28.69)	MDMLTTF.DS.DLPSA..GVAQPQGFNS
  196-  221 (31.39/18.26)	MD.LSMF.DSmDNQGSfgGLQSSSGMNE
  224-  244 (25.06/13.21)	NDPQMNFnDT.NAPPS..AVAVPE....
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33373 with Med2 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LEQQKLEQQKLEQQKLEQQKLEQQKLEQQKLEQQKYSAKNTPMDMLTTFDSDLPSAGVAQPQGFNSDFGDLNGMDLSMFDSMDNQGSFGGLQSSSGMNEKKNDPQMNFNDTNAPPSAVAVPESENPNSYLTL
123
254










Molecular Recognition Features






MoRF SequenceStartStop




1) LNGMDLSMFDSM
2) LNLEDFNL
3) YLTLNDFNDLGIDWNAAND
193
273
251
204
280
269